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Aldo Peixoto, MD

Professor of Medicine (Nephrology); Vice Chair for Quality & Safety, Department of Internal Medicine; Clinical Chief, Section of Nephrology

Contact Information

Aldo Peixoto, MD

Office Location

Yale Medicine

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Research Summary

My primary interest has been in the interplay between hypertension, kidney disease and vascular disease. Current interests include:

- Profile and outcomes of acute severe hypertension in hospitalized patients (Lama Ghazi MD PhD, Aldo Peixoto MD and Perry Wilson MD).

- Use of systemic hemodynamics to phenotype hypertension as a tool to redefine mechanisms of hypertension (cross sectional study, PI Marcelo Orias MD PhD).

- Study of arterial mechanics in elderly patients with hypertension (cohort study, PI Sebastiao Ferreira MD PhD).

- Clinical trials (Site PI: Aldo Peixoto): 1) droxidopa in neurogenic orthostatic hypotension (RESTORE).

(Updated January 2022)

Coauthors

Research Interests

Antihypertensive Agents; Hemodynamics; Hypertension; Hypotension, Orthostatic; Reproducibility of Results; Vascular Stiffness; Hemodynamic Monitoring

Research Images

Excessive Blood Pressure Response to Clonidine in Hospitalized Patients with Asymptomatic Severe Hypertension
Clonidine is a go-to drug in patients with acute severe hypertension without acute target organ injury. Previous data suggested that its "smoother" pattern of BP decline made it a useful drug. In this study, we challenge this concept, as up to 16% of patients had excessive BP reductions (>30%) and 7% had significant adverse events within 24h, mostly acute kidney injury. (Hanna, Ghazi, Yamamoto, Simonov, Shah, Wilson and Peixoto. Am J Hypertension 2022: doi: 10.1093/ajh/hpac004. Online ahead of print.)

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