Ruth Asch
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study. The International Journal Of Neuropsychopharmacology 2025, pyaf040. PMID: 40511849, DOI: 10.1093/ijnp/pyaf040.Peer-Reviewed Original ResearchAnterior cingulate cortexDorsolateral prefrontal cortexFusiform gyrusAnxiety symptomsSV2A densitySynaptic densityState anxietyMediation analysisPain sensitivityAssociated with greater pain sensitivityAssociated with painState anxiety symptomsFunctional brain alterationsMedically healthy subjectsIndirect effectsPrefrontal cortexCingulate cortexPlasma input functionBrain alterationsOne-tissue compartment modelPET imaging studiesGyrusAnxietyRegional volumesHigher pain sensitivityEvaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats
Balayeva T, Asch R, Tan P, Mennie W, Tong J, Chen B, Zhuang Z, Zheng C, Zheng M, Toyonaga T, Cai Z. Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats. Nuclear Medicine And Biology 2025, 146: 109029. PMID: 40383020, DOI: 10.1016/j.nucmedbio.2025.109029.Peer-Reviewed Original ResearchPositron emission tomographyParent fractionSynaptic vesicle glycoprotein 2ANeuropsychiatric disordersBrain regionsRadiometabolite analysisPET imaging dataLongitudinal studyRadiometabolitesRadio-HPLCArterial blood samplesEmission tomographyBrainMetabolic correctionIntravenous infusionPlasma concentrationsPET quantificationSV2AKinetic modelBlood samplesRadio-high-performance liquid chromatographyPost-injectionRatsRadio-HPLC methodRadio thin layer chromatography270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats
Asch R, Garcia-Milian R, Hernandez-Martin N, Cai Z, Esterlis I. 270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats. Biological Psychiatry 2025, 97: s207. DOI: 10.1016/j.biopsych.2025.02.508.Peer-Reviewed Original Research52. The Role of Synaptic Density and Anxiety Symptoms in Modulating Pain Perception: Evidence From a [11C]UCB-J PET Imaging Study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. 52. The Role of Synaptic Density and Anxiety Symptoms in Modulating Pain Perception: Evidence From a [11C]UCB-J PET Imaging Study. Biological Psychiatry 2025, 97: s116. DOI: 10.1016/j.biopsych.2025.02.289.Peer-Reviewed Original ResearchVenous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET
Asch R, Naganawa M, Moisieienko K, Weed M, Kapinos M, Zheng M, Hillmer A, Carson R, Pietrzak R, Esterlis I. Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET. EJNMMI Research 2025, 15: 8. PMID: 39900828, PMCID: PMC11790547, DOI: 10.1186/s13550-025-01200-2.Peer-Reviewed Original Research
2024
An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder
Davis M, Asch R, Weiss E, Wagner A, Fineberg S, Nabulsi N, Matuskey D, Carson R, Esterlis I. An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 10: 324-332. PMID: 39613160, PMCID: PMC12009513, DOI: 10.1016/j.bpsc.2024.11.014.Peer-Reviewed Original ResearchBorderline personality disorderPathophysiology of borderline personality disorderSuicide attemptsPersonality disorderPositron emission tomographyAssociated with history of suicide attemptBorderline personality disorder symptomsBPD pathophysiologyPositron emission tomography outcomes measurementsHistory of suicide attemptsMetabotropic glutamate receptor type 5Metabotropic glutamate receptor 5Glutamate receptor 5Comprehensive clinical assessmentFrontolimbic circuitsMDD groupDepressive disorderEmotion regulationPsychiatric conditionsCognitive functionMGlu5Comparison controlsMDDSuicideAssociated with historyMetabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use
Weiss E, Davis M, Asch R, D'Souza D, Cool R, Esterlis I. Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use. The International Journal Of Neuropsychopharmacology 2024, 27: pyae044. PMID: 39320043, PMCID: PMC11969217, DOI: 10.1093/ijnp/pyae044.Peer-Reviewed Original ResearchTrauma-related psychopathologyCannabis useDepressive symptomsPositron emission tomographyCross-diagnostic sampleMetabotropic glutamate receptor 5Treatment development effortsAssociated with depressive symptomsGlutamate receptor 5CU groupSample of individualsAvailability in vivoFrontolimbic regionsGlutamatergic systemGlutamatergic neurotransmissionMGlu5PsychopathologyReceptor 5Intersection of traumaExploratory analysisCannabisEmission tomographySymptomsParticipantsVmPFCChallenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Asch R, Abdallah C, Carson R, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology 2024, 50: 153-163. PMID: 39039139, PMCID: PMC11525584, DOI: 10.1038/s41386-024-01913-3.Peer-Reviewed Original ResearchStudies of depressionAnimal models of chronic stressPositron emission tomographyModel of chronic stressSV2A imagingSynaptic densitySignificant depressive symptomsDevelopment of novel radiotracersDepressive symptomsNeuropsychiatric disordersSymptom severityChronic stressDrug challengeSynaptic vesicle glycoprotein 2 ANeural markersAnimal modelsSynaptic alterationsSynaptogenesis in vivoPreliminary findingsIn vivo quantificationCentral nervous systemDepressionEmission tomographySV2ASV2A positron emission tomographyW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original ResearchDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment development
Academic Achievements & Community Involvement
News
News
- November 25, 2024
Yale Center for the Science of Cannabis and Cannabinoids Announces Inaugural Pilot Award Winners
- February 07, 2024
Asch Selected to Receive SOBP Travel Fellowship Award
- September 07, 2023
Asch Chosen to Receive YCCI Scholar Award
- November 15, 2022Source: Biological Psychiatry
Yale Study Seeks to Understand Neurobiology Underlying Bipolar Disorder Vs. Major Depressive Disorder
Get In Touch
Contacts
Email
Mailing Address
Yale School of Medicine
40 Temple Street, Suite 7C, Office 750
New Haven, CT 06519
United States