1996
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong W, Feder J, Jiang M, Jan L, Jan Y. Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis. Neuron 1996, 17: 43-53. PMID: 8755477, DOI: 10.1016/s0896-6273(00)80279-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DivisionCell MembraneCerebral CortexDrosophilaDrosophila ProteinsEmbryo, MammalianEmbryo, NonmammalianEmbryonic and Fetal DevelopmentJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataMutationNeuronsRatsReceptors, Cell SurfaceReceptors, NotchSequence Homology, Amino AcidTissue DistributionConceptsMouse cortical neurogenesisDaughter cellsAsymmetric cell divisionCortical neurogenesisCell-cell interactionsDrosophila neurogenesisMammalian homologMutant phenotypeMouse Notch1Drosophila embryosDistinct fatesDrosophila NumbAsymmetric divisionAsymmetric localizationCell divisionDifferential segregationMolecular mechanismsNeural progenitorsNumbNeural precursorsApical membraneHomologNeurogenesisInvertebratesVertebrates
1994
Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.
Zhong W, Mirkovitch J, Darnell J. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Molecular And Cellular Biology 1994, 14: 7276-7284. PMID: 7523862, PMCID: PMC359262, DOI: 10.1128/mcb.14.11.7276.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBinding SitesDeoxyribonuclease IDNA ProbesDNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 4KidneyLiverLiver Neoplasms, ExperimentalMiceMice, TransgenicMolecular Sequence DataPhosphoproteinsPromoter Regions, GeneticRNATissue DistributionTranscription FactorsTransfectionTumor Cells, CulturedConceptsTransient transfection assaysLiver-enriched transcription factorsHNF-4HNF-4 geneLiver-specific expressionTranscription factorsPresence of DNase I-hypersensitive sitesHNF-1 binding siteDNase I hypersensitive sitesHepatocyte nuclear factor 4Distal enhancer elementsDNase hypersensitive sitesHepatoma-specific expressionSteroid hormone receptor superfamilyHNF-4 expressionTissue-specific expressionHNF-1 alphaHormone receptor superfamilyExpression of HNF-4RNA startDNA elementsEnhancer elementsHNF-1Promoter regionReporter constructs