2024
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix
Bellone S, Jeong K, Halle M, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich T, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Quick C, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov L, Siegel E, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2321898121. PMID: 38625939, PMCID: PMC11046577, DOI: 10.1073/pnas.2321898121.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingPatient-derived-xenograftsBase excision repairCopy number lossMultiregion whole-exome sequencingCopy number gainHigh-grade neuroendocrine carcinomaCNV analysisPhylogenetic analysisEvolutionary historyNeuroendocrine cervical cancerHuman papillomavirus DNAMutator phenotypeSensitivity to afatinibGenetic landscapeRecurrent mutationsRNA sequencingGene fusionsMutational landscape analysisExcision repairGenesMutationsPan-HERConsistent with deficiencyNeuroendocrine carcinoma
2012
Anterior pelvic exenteration with total vaginectomy for recurrent or persistent genitourinary malignancies: Review of surgical technique, complications, and outcome
Andikyan V, Khoury-Collado F, Gerst S, Talukdar S, Bochner B, Sandhu J, Abu-Rustum N, Sonoda Y, Barakat R, Chi D. Anterior pelvic exenteration with total vaginectomy for recurrent or persistent genitourinary malignancies: Review of surgical technique, complications, and outcome. Gynecologic Oncology 2012, 126: 346-350. PMID: 22555107, DOI: 10.1016/j.ygyno.2012.04.034.Peer-Reviewed Original ResearchConceptsAnterior pelvic exenterationPelvic exenterationTotal vaginectomyPelvic recurrencePostoperative complicationsGenitourinary malignanciesSurgical techniqueNegative pathologic marginsPreliminary survival dataMajor postoperative complicationsMedian tumor sizeEvidence of diseaseRate of readmissionComplete surgical resectionTotal pelvic exenterationCentral pelvic recurrencePrimary tumor sitePancreatic recurrenceOperative mortalityOncologic outcomesSurgical resectionMedian ageCase seriesPathologic marginsTumor size