2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2023
Incisional infiltration versus transversus abdominis plane block of liposomal bupivacaine after midline vertical laparotomy for suspected gynecologic malignancy: a pilot study
Moon A, Andikyan V, Agarwal R, Stroever S, Misita D, Laibangyang A, Doo D, Chuang L. Incisional infiltration versus transversus abdominis plane block of liposomal bupivacaine after midline vertical laparotomy for suspected gynecologic malignancy: a pilot study. Gynecologic Oncology Reports 2023, 47: 101203. PMID: 37251783, PMCID: PMC10220396, DOI: 10.1016/j.gore.2023.101203.Peer-Reviewed Original ResearchLiposomal bupivacaineTransversus abdominis planeIncisional infiltrationOpioid requirementsPain scoresVertical laparotomyTAP blockGynecologic malignanciesBupivacaine hydrochlorideTransversus abdominis plane blockPilot studyOpen gynecologic surgeryTAP block groupTotal opioid useOpioid usePlane blockPostoperative periodSecondary outcomesPrimary outcomeGynecologic cancerInfiltration groupGynecologic surgeryClinical differencesGynecologic laparotomyBupivacaine
2018
Enhanced Recovery after Surgery (ERAS) in Gynecologic Surgery—A Review
Moon A, Tangada A, Andikyan V, Chuang L. Enhanced Recovery after Surgery (ERAS) in Gynecologic Surgery—A Review. Current Obstetrics And Gynecology Reports 2018, 7: 122-132. DOI: 10.1007/s13669-018-0247-1.Peer-Reviewed Original ResearchERAS implementationGynecologic oncologyERAS protocolGynecologic surgeryEnhanced recoveryMajority of studiesEarly postoperative feedingUrinary catheter removalMechanical bowel preparationRate of readmissionMaintenance of normothermiaRetrospective observational studyLength of stayPostoperative feedingMultimodal analgesiaCatheter removalERAS programPostoperative complicationsSecondary outcomesGeneral gynecologyPreoperative dietPrimary outcomeEarly mobilizationBowel preparationRetrospective study