Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue
Pandya D, Tomita S, Rhenals M, Swierczek S, Reid K, Camacho-Vanegas O, Camacho C, Engelman K, Polukort S, RoseFigura J, Chuang L, Andikyan V, Cohen S, Fiedler P, Sieber S, Shih I, Billaud J, Sebra R, Reva B, Dottino P, Martignetti J. Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue. Gynecologic Oncology 2024, 185: 194-201. PMID: 38452634, DOI: 10.1016/j.ygyno.2024.02.027.Peer-Reviewed Original ResearchMyometrial layerUterine tissueSomatic mutationsPrevalence of somatic mutationsIncreasing patient ageNormal endometrial tissuesComplex mutation patternsMutant allele frequencyCancer-relevant genesSomatic mutation landscapeMutation prevalencePatient ageEndometrial cancerNon-functional mutationsGene panelEndometrial tissueGynecologic cancerMutation profilesUterine samplesMutational landscapeScreening testMutation patternsFunction mutationsMortality rateUnique mutations