2014
Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1
Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP. Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflügers Archiv - European Journal Of Physiology 2014, 467: 1457-1468. PMID: 25127675, DOI: 10.1007/s00424-014-1593-0.Peer-Reviewed Original ResearchConceptsGastric parietal cellsPotassium channelsParietal cellsΒ-subunitKir1.1 channelsWild-type miceSecretagogue-stimulated gastric acid secretionApical poleGastric glandsLeak pathwayPotential therapeutic targetKir1.1Proton secretionRegulatory characteristicsKv7.1Therapeutic targetATPaseCell numberParietal cell numberCellsNormal gastric acid secretionSecretionInhibitorsAcid secretionMice
2010
Mechanotransduction in the renal tubule
Weinbaum S, Duan Y, Satlin LM, Wang T, Weinstein AM. Mechanotransduction in the renal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1220-f1236. PMID: 20810611, PMCID: PMC3006307, DOI: 10.1152/ajprenal.00453.2010.Peer-Reviewed Original Research
2007
Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium
Duan Y, Du Z, Yan Q, Weinstein A, Weinbaum S, Wang T. Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium. The FASEB Journal 2007, 21: a915-a915. DOI: 10.1096/fasebj.21.6.a915-a.Peer-Reviewed Original ResearchCytoskeleton reorganizationPeripheral actin networkMPT cellsCell-cell contactZO-1Actin cytoskeletonCellular functionsEpithelial cytoskeletonActin networkJunction-like structuresStress fibersF-actinVinculin expressionCytoskeletonFluid shear stressE-cadherinCollagen substrateMechanical forcesEndothelial cellsCellsH-ATPase activityPT cellsStructural frameworkDifferent responsesStructural components