Tingting Wang
Associate Research ScientistAbout
Research
Publications
2026
Discovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt/β-catenin signaling pathway
Zhai Y, Zhang J, Yang J, Wang T, Gao J, Wang W, Han W. Discovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt/β-catenin signaling pathway. Bioorganic Chemistry 2026, 175: 109768. PMID: 41865565, DOI: 10.1016/j.bioorg.2026.109768.Peer-Reviewed Original ResearchTen-membered lactoneCrystal X-ray diffractionJ-based configuration analysisOxidative cleavage productsX-ray diffractionModified Mosher's methodDevelopment of lead compoundsLactone unitsRing systemCompound 4Compound 8Lactone monomersCompounds 1Mosher's methodSpectroscopic dataLead compoundsLactoneCompoundsChemical diversityConfiguration analysisDiffractionCleavage productsMonomerDimerCrystalFrom structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy
Lin L, Wu J, Wang T, Cao Y, Zhang D, Jin H, He S. From structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy. European Journal Of Medicinal Chemistry 2026, 309: 118768. PMID: 41864040, DOI: 10.1016/j.ejmech.2026.118768.Peer-Reviewed Original ResearchReceptor agonistsCentral nervous system adverse effectsClinical approvalInsufficient clinical responseWomen of Childbearing AgeSystemic adverse effectsProportion of patientsAntimigraine therapyClinical responseTrigeminal neuronsMigraine therapyChildbearing ageGlobal disease burdenMigraine managementSmall molecule agonistsMigraineTherapeutic potentialAgonistsTherapyTherapeutic targetDisease burdenAdverse effectsNeurological disordersStructural evolutionIndole-based scaffoldsFree apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans
Ruan H, Chen A, Xue Y, Lee K, Fong S, Qiu Q, Tan Y, Feng Y, Lee C, Hua R, Huang J, Wang T, Xu Y, Lee K, Xi N, Li R, Ng E, Yeung W, Lee Y. Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans. Human Reproduction 2026, deag009. PMID: 41704048, DOI: 10.1093/humrep/deag009.Peer-Reviewed Original ResearchEndometrial epithelial cellsExpression of CDH1Blastocyst-endometrium interactionHuman blastocystsApical expressionEmbryo-maternal interactionsEndometrial receptivityConditioned mediumImplant failureEmbryonic signalsApical surfaceImmunofluorescence stainingProtein expressionEmbryo attachmentLive birthsApical redistributionTrophectoderm of human blastocystsEpithelial cellsPolar trophectodermEvaluation of endometrial receptivityApical regionEndometrial adenocarcinoma cell lineExpression of adhesion-related moleculesPrimary endometrial epithelial cellsShenzhen Science and Technology ProgramThe Gut–Liver Axis in MASLD: From Host–Microbiome Crosstalk to Precision Therapeutics
Zhou J, Zhu B, Bing Z, Wang T, Zhao Y. The Gut–Liver Axis in MASLD: From Host–Microbiome Crosstalk to Precision Therapeutics. Microorganisms 2026, 14: 471. PMID: 41753757, PMCID: PMC12942669, DOI: 10.3390/microorganisms14020471.Peer-Reviewed Original ResearchGut-liver axisGut-liverHost-microbiome crosstalkMicrobiome-based interventionsSteatotic liver diseaseGut-derived productsIntestinal barrier integrityHost metabolismGut microbiotaMicrobial ecosystemTranslational landscapeHost microbiomeMetabolic dysbiosisPrecision therapeuticsDisease modifiersBarrier integrityEffective therapeutic optionPersonalized therapeutic strategiesExtrinsic factorsNon-invasive biomarkersTherapeutic strategiesTherapeutic optionsRisk stratificationHepatic insultImmune activationElovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming
Bi Z, Chang X, Zhu S, Fu S, Zhang Y, Wang T, Wang F, Zhuang H, Hua Z. Elovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming. Science Advances 2026, 12: eadz2892. PMID: 41686894, PMCID: PMC12904185, DOI: 10.1126/sciadv.adz2892.Peer-Reviewed Original ResearchConceptsMetabolic reprogrammingMitochondrial fusionPhospholipid biosynthesis pathwayColorectal cancerLipid metabolic reprogrammingIntestinal microbial homeostasisLipid metabolizing enzymesColorectal cancer progressionColon cancer tissuesBiosynthesis pathwayMicrobial homeostasisOpportunistic pathogenLow expression levelsTumor growth in vivoGrowth in vivoMolecular mechanismsCellular proliferation in vitroMetabolic enzymesColorectal cancer preventionELOVL6Protein 6Down-regulationProliferation in vitroUnfavorable patient prognosisCancer progression
2025
AT-56 ENHANCES OOCYTE COMPETENCE IN REPRODUCTIVELY AGED MICE
Hua R, Hai Z, Yeung W, Wang T. AT-56 ENHANCES OOCYTE COMPETENCE IN REPRODUCTIVELY AGED MICE. Fertility And Sterility 2025, 124: e181-e182. DOI: 10.1016/j.fertnstert.2025.07.566.Peer-Reviewed Original ResearchGut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis
Zhao Z, Wu S, Wang T, Zhao Y. Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis. Acta Biochimica Et Biophysica Sinica 2025, 58: 106-119. PMID: 41311218, PMCID: PMC12862605, DOI: 10.3724/abbs.2025220.Peer-Reviewed Original ResearchConceptsMicrobial rhythmsHost circadian clockMicrobial community compositionHost immune modulationImpaired intestinal barrier functionCommunity compositionGut microbiotaPathogenesis of metabolic disordersMicrobial signalsMetabolic outputTemporal regulationIntestinal barrier functionCircadian clockHost immunityImmunometabolic diseasesMicrobiotaMaladaptive immune responsesSystemic metabolic dysregulationSpatial organizationHostSleep-wake cycleMetabolic activityDiurnal oscillationsFeeding patternsRhythmic behaviorCorrigendum to “Broxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases” [Int. Immunopharmacol. 156 (2025) 114687]
Tang H, Zou X, Chen P, Wang Y, Gao S, Wang T, Xu Y, Ji S. Corrigendum to “Broxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases” [Int. Immunopharmacol. 156 (2025) 114687]. International Immunopharmacology 2025, 168: 115915. PMID: 41276450, DOI: 10.1016/j.intimp.2025.115915.Peer-Reviewed Original ResearchAspergillus fumigatus promotes tumor angiogenesis via SLC7A11 on myeloid-derived suppressor cells
Qu W, Wang Z, Zhu T, Cui H, Bing Z, Shen S, Shen Y, Yu S, Zhuang H, Wang T. Aspergillus fumigatus promotes tumor angiogenesis via SLC7A11 on myeloid-derived suppressor cells. EMBO Reports 2025, 26: 6266-6291. PMID: 41249582, PMCID: PMC12715260, DOI: 10.1038/s44319-025-00627-x.Peer-Reviewed Original ResearchConceptsMyeloid-derived suppressor cellsHigh mobility group box 1A. fumigatusTumor angiogenesisSuppressor cellsAspergillus fumigatusAccumulation of myeloid-derived suppressor cellsTumor-associated myeloid-derived suppressor cellsAbility of tumor cellsMobility group box 1VEGF-A secretionImpact of fungiLung cancer preventionSolute carrier family 7 memberInfluence host immunityProangiogenic abilityTumor burdenG-MDSCsTumor cellsTumor progressionLung cancerTumor tissuesVEGF-AMouse modelBox 1Marine-derived natural products as anti-osteoporosis agents
Zheng Q, Khan S, Li J, Wang T. Marine-derived natural products as anti-osteoporosis agents. European Journal Of Medicinal Chemistry 2025, 302: 118284. PMID: 41138334, DOI: 10.1016/j.ejmech.2025.118284.Peer-Reviewed Original ResearchConceptsMarine-derived compoundsGenome miningMarine fungiMarine-derived natural productsNatural productsBiosynthetic pathwayOsteoporosis treatmentSynthetic biologyMarine ecosystemsBiotechnological advancesAnti-osteoporosis agentsNatural resourcesAnti-osteoporotic activityOsteoporosis therapeuticsBone resorptionAnti-osteoporosis activity