1998
Rabies Virus Entry into Endosomes in IMR-32 Human Neuroblastoma Cells
Lewis P, Fu Y, Lentz T. Rabies Virus Entry into Endosomes in IMR-32 Human Neuroblastoma Cells. Experimental Neurology 1998, 153: 65-73. PMID: 9743568, DOI: 10.1006/exnr.1998.6879.Peer-Reviewed Original ResearchConceptsIMR-32 human neuroblastoma cellsRabies virus entryHuman neuroblastoma cellsRabies virusNeuroblastoma cellsNerve terminalsCell bodiesVirus entryIMR-32 neuroblastoma cellsSynaptic vesicle markersLucifer YellowCell surfaceSynapsin ITransferrin receptorVirusTexas Red dextranEarly eventsVesicle markersVirus particlesImmunofluorescence microscopy
1997
Rabies virus infection of IMR-32 human neuroblastoma cells and effect of neurochemical and other agents
Lentz T, Fu Y, Lewis P. Rabies virus infection of IMR-32 human neuroblastoma cells and effect of neurochemical and other agents. Antiviral Research 1997, 35: 29-39. PMID: 9224959, DOI: 10.1016/s0166-3542(97)01036-x.Peer-Reviewed Original ResearchConceptsIMR-32 human neuroblastoma cellsIMR-32 cellsHuman neuroblastoma cellsNeuroblastoma cellsNeuronal nicotinic acetylcholine receptorsCentral nervous system receptorsRabies virusRabies virus infectionLysosomotropic agentsReceptor alpha1 subunitNicotinic acetylcholine receptorsNerve cell lineAttachment of virusNeurotropic virusesCholinergic agonistsViral antigensVirus infectionHuman neuronsAcetylcholine receptorsSynthetic peptidesCell bodiesInfectionAlpha1 subunitCholinergic ligandsBinding receptors
1995
Differential binding of nicotine and alpha-bungarotoxin to residues 173-204 of the nicotinic acetylcholine receptor alpha 1 subunit.
Lentz T. Differential binding of nicotine and alpha-bungarotoxin to residues 173-204 of the nicotinic acetylcholine receptor alpha 1 subunit. Biochemistry 1995, 34: 1316-22. PMID: 7827079, DOI: 10.1021/bi00004a026.Peer-Reviewed Original Research
1990
The recognition event between virus and host cell receptor: a target for antiviral agents
Lentz T. The recognition event between virus and host cell receptor: a target for antiviral agents. Journal Of General Virology 1990, 71: 751-766. PMID: 2109039, DOI: 10.1099/0022-1317-71-4-751.Peer-Reviewed Original Research
1988
Binding of alpha-bungarotoxin to synthetic peptides corresponding to residues 173-204 of the alpha subunit of Torpedo, calf, and human acetylcholine receptor and restoration of high-affinity binding by sodium dodecyl sulfate.
Wilson P, Lentz T. Binding of alpha-bungarotoxin to synthetic peptides corresponding to residues 173-204 of the alpha subunit of Torpedo, calf, and human acetylcholine receptor and restoration of high-affinity binding by sodium dodecyl sulfate. Biochemistry 1988, 27: 6667-74. PMID: 3196679, DOI: 10.1021/bi00418a004.Peer-Reviewed Original ResearchSynthetic peptides in the study of the interaction of rabies virus and the acetylcholine receptor.
Lentz T, Hawrot E, Donnelly-Roberts D, Wilson P. Synthetic peptides in the study of the interaction of rabies virus and the acetylcholine receptor. Advances In Biochemical Psychopharmacology 1988, 44: 57-71. PMID: 3041753.Peer-Reviewed Original ResearchConceptsSnake venom neurotoxinsAmino acid sequence similarityCentral nervous systemAcetylcholine receptorsVirus glycoproteinVenom neurotoxinsPeriod of replicationRabies virus glycoproteinRegions of virusesNervous systemGenetic driftSequence similarityVirus-receptor interactionsMolecular basisRabies virusCertain neuronal populationsDirect bindingRNA virusesNicotinic acetylcholine receptorsCell surface constituentsBlood-brain barrierCell receptorGlycoproteinBindingD-tubocurarine
1985
Rabies virus binding to cellular membranes measured by enzyme immunoassay
Lentz T, Chester J, Benson R, Hawrot E, Tignor G, Smith A. Rabies virus binding to cellular membranes measured by enzyme immunoassay. Muscle & Nerve 1985, 8: 336-345. PMID: 16758601, DOI: 10.1002/mus.880080411.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAnimalsAntibodiesBinding Sites, AntibodyBinding, CompetitiveCationsCell MembraneChick EmbryoCricetinaeDogsEmbryo, MammalianEnzyme-Linked Immunosorbent AssayGuinea PigsHumansHydrogen-Ion ConcentrationMiceMuscle Fibers, SkeletalNeuroblastomaPropiolactoneRabies virusRatsReceptors, CholinergicTemperatureTrypsinConceptsEnzyme-linked immunosorbent assayRabies virusAcetylcholine receptor contentTreatment of virusRabies virus antibodiesMost parenchymal organsReceptor contentSalivary gland membranesVirus antibodiesAcetylcholine receptorsParenchymal organsEnzyme immunoassayImmunosorbent assaySimilar developmental changesEmbryonic chick myotubesGland membranesSurface moleculesVirusMyotube membranesAntibodiesSecond antibodyInactivation of virusesChick myotubesDevelopmental changesLow levels
1983
The acetylcholine receptor as a cellular receptor for rabies virus.
Lentz T, Burrage T, Smith A, Tignor G. The acetylcholine receptor as a cellular receptor for rabies virus. The Yale Journal Of Biology And Medicine 1983, 56: 315-22. PMID: 6367238, PMCID: PMC2589619.Peer-Reviewed Original ResearchConceptsAcetylcholine receptorsHost cell receptorsRabies virusSpecific host cell receptorsCell receptorTissue tropismMotor nerve endingsRabies virus pathogenesisMyasthenia gravisAutoimmune diseasesCultured muscle cellsNerve endingsTranssynaptic transferViral antigensViral immunizationVirus pathogenesisDisease processNeurotransmitter receptorsViral infectionIntact hostCellular tropismNeuromuscular junctionInfected animalsMuscle cellsVirus attachment
1972
Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies
Zeldis S, Nemerson Y, Pitlick F, Lentz T. Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies. Science 1972, 175: 766-768. PMID: 5057816, DOI: 10.1126/science.175.4023.766.Peer-Reviewed Original ResearchConceptsTissue factorEndothelial cellsTissue factor antigenHuman atheromatous plaquesFactor antigenAtheromatous plaquesHuman tissue factorCytologic localizationBlood vesselsPeroxidase conjugated antibodyPeroxidase-conjugated antibodyAntibodiesCell typesPlasma membraneCellsThrombosisAtheromaFactorsHemostasisAntigenIntimaPlaques
1962
The effect of enzyme substrates and pharmacological agents on nematocyst discharge
Lentz T, Barrnett R. The effect of enzyme substrates and pharmacological agents on nematocyst discharge. Journal Of Experimental Zoology 1962, 149: 33-38. PMID: 14464028, DOI: 10.1002/jez.1401490104.Peer-Reviewed Original Research