2020
Systemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer.
Slovak R, Park H, Kamp W, Ludwig J, Kang I, Kim H. Systemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer. Journal Of Clinical Oncology 2020, 38: 198-198. DOI: 10.1200/jco.2020.38.4_suppl.198.Peer-Reviewed Original ResearchDual immune checkpoint blockadeTreatment days 0Target tumorTumor volumeDay 0Anti-cancer immune responseBALB/c miceAddition of immunotherapyImmune checkpoint blockadeTreatment day 2Colorectal cancer cellsInjection of antibodiesFull ablationCheckpoint blockadeColorectal cancerC miceSham injectionMean changeImmune responseMurine modelControl animalsCryoablationDay 2Tumor growthFlank injection
2019
Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation
Slovak R, Raja J, Case M, Kim H. Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation. Digestive Disease Interventions 2019, 03: 143-154. DOI: 10.1055/s-0039-1679935.Peer-Reviewed Original ResearchImmune responseThermal ablationSitu tumor vaccineSystemic immunological effectsAnticancer immune responseAdaptive immune responsesFocused ultrasound ablationTumor vaccinesImmunological effectsAblative techniquesInterventional oncologyInvasive formUltrasound ablationAblationResponseMonotherapyPalliationImmunotherapyCryoablationMalignancyVaccineOncology
2017
Immuno-thermal ablations – boosting the anticancer immune response
Slovak R, Ludwig JM, Gettinger SN, Herbst RS, Kim HS. Immuno-thermal ablations – boosting the anticancer immune response. Journal For ImmunoTherapy Of Cancer 2017, 5: 78. PMID: 29037259, PMCID: PMC5644150, DOI: 10.1186/s40425-017-0284-8.Peer-Reviewed Original ResearchConceptsImmune responseImmune effectsRobust antitumor responseAnticancer immune responseImmune modulating drugsUse of immunomodulationSystemic antitumor activityCheckpoint blockadeAntitumor responseAblative therapyCombination therapyRadiofrequency ablationAblative techniquesModulating drugsAnimal modelsAntitumor activityThermal ablationTherapeutic appealImmunomodulationTherapyAblationResponseMonotherapyImmunomodulatorsCryoablation