1987
Interaction of the 4 S polycyclic aromatic hydrocarbon-binding protein with the cytochrome P-450c gene
Houser W, Cunningham C, Hines R, Schaeffer W, Bresnick E. Interaction of the 4 S polycyclic aromatic hydrocarbon-binding protein with the cytochrome P-450c gene. Archives Of Biochemistry And Biophysics 1987, 259: 215-223. PMID: 2825598, DOI: 10.1016/0003-9861(87)90488-7.Peer-Reviewed Original ResearchStructural details of the human cytochrome P-450c gene
Iversen P, Heiger W, Bresnick E, Hines R. Structural details of the human cytochrome P-450c gene. Archives Of Biochemistry And Biophysics 1987, 256: 397-401. PMID: 3606130, DOI: 10.1016/0003-9861(87)90460-7.Peer-Reviewed Original Research
1986
The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue
Iversen P, Hines R, Bresnick E. The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue. BioEssays 1986, 4: 15-19. PMID: 3790107, DOI: 10.1002/bies.950040105.Peer-Reviewed Original ResearchConceptsRegulation of expressionEnzyme systemUbiquitous familySubstrate specificityGene expressionMultiple isozymesMolecular biologyCytochrome PToxic lesionsExogenous compoundsOxidative metabolismMechanisms of metabolismExpressionInducible cytochrome PIsozymesComplete understandingMetabolismBiochemical pharmacologyOrganismsBiologySpeciesRegulationWide varietyCascadeCurrent notions
1985
3-Methylcholanthrene-induced expression of the cytochrome P-450c gene
Foldes R, Hines R, Ho K, Shen M, Nagel K, Bresnick E. 3-Methylcholanthrene-induced expression of the cytochrome P-450c gene. Archives Of Biochemistry And Biophysics 1985, 239: 137-146. PMID: 4004253, DOI: 10.1016/0003-9861(85)90820-3.Peer-Reviewed Original ResearchConceptsNuclear RNA speciesCytochrome P-450c mRNARNA speciesCytochrome P-450c geneP-450c geneClone 46Nuclear transcription systemNuclear RNA precursorsNuclear RNA transportRat serum albumin geneDot hybridization experimentsSerum albumin geneNorthern blot analysisTranscriptional controlRNA transportRNA precursorsNuclear RNARegulation of inductionHybridization experimentsTranscription systemM13 subclonesAlbumin geneCytochrome P-450cRNA inductionSpeciesGene structure and nucleotide sequence for rat cytochrome P-450c
Hines R, Levy J, Conrad R, Iversen P, Shen M, Renli A, Bresnick E. Gene structure and nucleotide sequence for rat cytochrome P-450c. Archives Of Biochemistry And Biophysics 1985, 237: 465-476. PMID: 3838427, DOI: 10.1016/0003-9861(85)90300-5.Peer-Reviewed Original ResearchConceptsRat cytochrome P-450cRegulatory sequencesCDNA sequenceEntire geneSecond genomic cloneCommon ancestral geneGenomic blot analysisComplete cDNA sequenceIntron/exon junctionsPotential regulatory sequencesCytochrome P-450c mRNACytochrome P-450c genePartial cDNA cloneRat genomic libraryAmino acid sequenceCross-hybridization studiesGross structural differencesA fragmentGT/AGExon 2P-450c geneAncestral geneGene structureGenomic clonesCytochrome P3-450