Rajesh Kumar Kar
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Appointments
Hematology
Primary
Contact Info
About
Titles
Associate Research Scientist
Appointments
Hematology
Associate Research ScientistPrimary
Other Departments & Organizations
- Hematology
- Internal Medicine
Education & Training
- PhD
- IIT Bombay, Biotechnology (2014)
Research
Overview
previously I worked on Investigation of the role of Deoxyhypusine Synthase (DHPS) and translational elongation factor eIF5A in mouse neurodevelopment and identification of small molecules that enhances the DHPS activity in case of mutants in humans.
Before I worked broadly on how the post translational modification, especially phosphorylation and de-phosphorylation of C-Terminal Domain (CTD) of RNA polymerase II by Kinase Kin28/CDK7 and Phosphatase SSU72 respectively, regulate various stages of transcription from initiation to termination in yeast. Studied in more detail about how these events regulate the co-transcriptional splicing in yeast and how they crosstalk with exo-nucleases to regulate RNA buffering or maintenance of the RNA steady state level in cells.
Research at a Glance
Publications Timeline
A big-picture view of Rajesh Kumar Kar's research output by year.
7Publications
Publications
2022
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
Ziegler A, Steindl K, Hanner AS, Kar RK, Prouteau C, Boland A, Deleuze JF, Coubes C, Bézieau S, Küry S, Maystadt I, Le Mao M, Lenaers G, Navet B, Faivre L, Tran Mau-Them F, Zanoni P, Chung WK, Rauch A, Bonneau D, Park MH. Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder. Am J Hum Genet 2022, 109: 1549-1558. PMID: 35858628, DOI: 10.1016/j.ajhg.2022.06.010.Peer-Reviewed Original ResearchPost-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
Park MH, Kar RK, Banka S, Ziegler A, Chung WK. Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment. Amino Acids 2022, 54: 485-499. PMID: 34273022, DOI: 10.1007/s00726-021-03023-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Kar RK, Hanner AS, Starost MF, Springer D, Mastracci TL, Mirmira RG, Park MH. Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice. J Biol Chem 2021, 297: 101333. PMID: 34688659, DOI: 10.1016/j.jbc.2021.101333.Peer-Reviewed Original Research
2019
Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner.
Nemec CM, Singh AK, Ali A, Tseng SC, Syal K, Ringelberg KJ, Ho YH, Hintermair C, Ahmad MF, Kar RK, Gasch AP, Akhtar MS, Eick D, Ansari AZ. Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner. Nat Chem Biol 2019, 15: 123-131. PMID: 30598543, DOI: 10.1038/s41589-018-0194-1.Peer-Reviewed Original Research
2017
Multiple Conformations of Gal3 Protein Drive the Galactose-Induced Allosteric Activation of the GAL Genetic Switch of Saccharomyces cerevisiae.
Kar RK, Kharerin H, Padinhateeri R, Bhat PJ. Multiple Conformations of Gal3 Protein Drive the Galactose-Induced Allosteric Activation of the GAL Genetic Switch of Saccharomyces cerevisiae. J Mol Biol 2017, 429: 158-176. PMID: 27913116, DOI: 10.1016/j.jmb.2016.11.005.Peer-Reviewed Original Research
2014
Perturbation of the interaction between Gal4p and Gal80p of the Saccharomyces cerevisiae GAL switch results in altered responses to galactose and glucose.
Das Adhikari AK, Qureshi MT, Kar RK, Bhat PJ. Perturbation of the interaction between Gal4p and Gal80p of the Saccharomyces cerevisiae GAL switch results in altered responses to galactose and glucose. Mol Microbiol 2014, 94: 202-17. PMID: 25135592, DOI: 10.1111/mmi.12757.Peer-Reviewed Original ResearchStochastic galactokinase expression underlies GAL gene induction in a GAL3 mutant of Saccharomyces cerevisiae.
Kar RK, Qureshi MT, DasAdhikari AK, Zahir T, Venkatesh KV, Bhat PJ. Stochastic galactokinase expression underlies GAL gene induction in a GAL3 mutant of Saccharomyces cerevisiae. FEBS J 2014, 281: 1798-817. PMID: 24785355, DOI: 10.1111/febs.12741.Peer-Reviewed Original Research
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