Pei-Yu Chen, PhD

2026

• Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

  Zhang R, Zhu X, Bae H, Zhang J, Li Y, Chen P, Shen Y, Tellides G, Snyder N, Jang C, Schwartz M, Arany Z, Simons M. Metabolic control of smooth muscle cell phenotype switching in atherosclerosis. Science Advances 2026, 12: eaef6065. PMID: 42647644, PMCID: PMC13510649, DOI: 10.1126/sciadv.aef6065.

  Peer-Reviewed Original Research

  This study shows that the enzyme PDK4 controls smooth muscle cell behavior in atherosclerosis, with its suppression reducing plaque development in mice.

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