My long-term scientific interest is to study the structure-function relationship, regulation and clinical significance of membrane proteins. My early research project in Dr. Joachim Weber's group was focused on investigating the catalytic mechanism and chemo-mechanical coupling in ATP synthase. Later, I pursued structural and functional studies on nicotinic acetylcholine, GABAA and other pentameric ligand-gated ion channels of neurotransmitter receptors. My current research focuses on the role of ATP synthase in mitochondrial permeability transition and its impact on neurodegenerative disorders, aging and cancer. I am using the cryo-electron microscopy and patch-clamp recording techniques to characterize the enigmatic "cell death" channel located in mitochondrial ATP synthase. In-depth structural analysis of ATP synthase will reveal its “open channel” conformation and may lead to structure-based drug design of specific therapeutic compounds for the treatment of degenerative disorders.