Nelli Mnatsakanyan, PhD

Assistant Professor

Contact Information

Nelli Mnatsakanyan, PhD

Mailing Address

  • Endocrinology

    PO Box 208020 333 Cedar Street

    New Haven, CT, 06520-8056

    United States

Nelli Mnatsakanyan
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Appointments

Biography

My long-term scientific interest is to study the structure-function relationship, regulation and clinical significance of membrane proteins. My early research project in Dr. Joachim Weber's group was focused on investigating the catalytic mechanism and chemo-mechanical coupling in ATP synthase. Later, I pursued structural and functional studies on nicotinic acetylcholine, GABAA and other pentameric ligand-gated ion channels of neurotransmitter receptors. My current research focuses on the role of ATP synthase in mitochondrial permeability transition and its impact on neurodegenerative disorders, aging and cancer. I am using the cryo-electron microscopy and patch-clamp recording techniques to characterize the enigmatic "cell death" channel located in mitochondrial ATP synthase. In-depth structural analysis of ATP synthase will reveal its “open channel” conformation and may lead to structure-based drug design of specific therapeutic compounds for the treatment of degenerative disorders.

Education & Training

  • PhD
    Yerevan State University, Biophysics (2003)
  • MS
    Yerevan State University (1999)
  • BS
    Yerevan State University (1999)

Honors & Recognition

AwardAwarding OrganizationDate
Young Bioenergeticist AwardBiophysical Society2018
K01 Research Scientist Development AwardNational Institutes of Aging2017

Professional Service

OrganizationRoleDate
Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)Member2019 - Present
"Biomedicine & Pharmacotherapy" JournalAssociate Editor2018 - Present
Biophysical SocietyCo-organizer and co-chair of the Biophysical Society "Bioenergetics" Subgroup Symposium "High-resolution structure, function and dynamics of mitochondrial proteins".2017
"Bioenergetics, mitochondria and metabolism" Subgroup, Biophysical SocietyMember2015 - Present
Society of NeuroscienceMember2011 - Present
Biophysical SocietyMember2011 - Present

Departments & Organizations