Hippo signaling: bridging the gap between cancer and neurodegenerative disorders
Gogia N, Chimata AV, Deshpande P, Singh A, Singh A. Hippo signaling: bridging the gap between cancer and neurodegenerative disorders. Neural Regeneration Research 2020, 16: 643-652. PMID: 33063715, PMCID: PMC8067938, DOI: 10.4103/1673-5374.295273.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCell deathHippo pathwayGrowth regulationAberrant cell deathRole of HippoNeurodegenerative disordersCell proliferationCell death mechanismsCell death resultsOrgan sizeDeath mechanismsNeuronal cell populationsChemical inhibitorsHippoNormal developmentVariety of mechanismsFundamental processesCell proliferation resultsCell populationsPathwayVariety of diseasesNeurodegenerative diseasesRegulationDeath resultsProliferation resultsA Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration
Irwin M, Tare M, Singh A, Puli OR, Gogia N, Riccetti M, Deshpande P, Kango-Singh M, Singh A. A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration. Frontiers In Cell And Developmental Biology 2020, 8: 117. PMID: 32232042, PMCID: PMC7082232, DOI: 10.3389/fcell.2020.00117.Peer-Reviewed Original ResearchHippo signalingJNK signalingCell deathKinase Signaling PathwayTriggers cell proliferationActivation of HippoDeficiency screenTargeted misexpressionNeurodegeneration phenotypePositive feedback loopAge-related disordersTerminal kinaseSignaling pathwaysAberrant signalingAccumulation of Aβ42HippoNovel roleNeurodegenerative phenotypeGenetic modifiersHuman Aβ42SignalingCell proliferationDeath of neuronsAβ42 plaquesPathway