Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo
Gogia N, Sarkar A, Mehta A, Ramesh N, Deshpande P, Kango-Singh M, Pandey UB, Singh A. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Neurobiology Of Disease 2020, 140: 104837. PMID: 32199908, PMCID: PMC9277911, DOI: 10.1016/j.nbd.2020.104837.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAxonsCytoplasmDisease Models, AnimalDrosophilaDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase 4Motor NeuronsMutationNerve DegenerationNeuromuscular JunctionPhenotypeProtein Serine-Threonine KinasesProtein TransportRNA-Binding Protein FUSSignal TransductionConceptsDrosophila eyeHippo signalingJNK signalingAmyotrophic lateral sclerosisCell deathC-Jun amino-terminal kinaseGenetic modifiersInactivation of HippoCJun N-terminal kinaseTrigger cell deathAmino-terminal kinaseGrowth regulatory pathwaysLate-onset neurodegenerative disorderTargeted misexpressionRNA metabolismPromotes Cell ProliferationHippo pathwayInteresting phenotypesDrosophila modelGenetic mechanismsHuman FUSFUS accumulationRegulatory pathwaysAxonal targetingCytoplasmic mislocalizationA soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Scientific Reports 2018, 8: 13545. PMID: 30202077, PMCID: PMC6131139, DOI: 10.1038/s41598-018-31787-7.Peer-Reviewed Original ResearchConceptsRetinal neuronsNeuroprotective roleAlzheimer's diseaseHuman Aβ42Fatal progressive neurodegenerative disorderNovel neuroprotective roleProgressive neurodegenerative disorderAnti-cancer effectsPotential therapeutic agentJNK signalingAβ42 plaquesNeuronal deathNeuroprotective functionMortality rateTransgenic modelAxonal targetingNeurodegenerative disordersTherapeutic agentsCJun N-terminal kinaseNeurodegenerationOxidative stressAβ42NeuronsAbnormal signalingLunasin