2013
MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells
Rani S, Rathod S, Karthik S, Kaur N, Muzumdar D, Shiras A. MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro-Oncology 2013, 15: 1302-1316. PMID: 23814265, PMCID: PMC3779040, DOI: 10.1093/neuonc/not090.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternBrain NeoplasmsCalmodulin-Binding ProteinsCell AdhesionCell CycleCell MovementCell ProliferationGliomaHumansMiceMice, Inbred NODMice, SCIDMicroRNAsNeoplastic Stem CellsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSOX9 Transcription FactorConceptsAdducin 3MiR-145Overexpression of moleculesCell proliferationGlioma cellsHNGC-2 cellsModel cell systemMiR-145 promoterTumor suppressive functionMiR-145 functionsGuanine (CpG) islandsMiR-145 overexpressionEctopic expressionGrowth-suppressive effectsMiR-145 lossHuman glioma cellsCell adhesionC-MycFunctional studiesN-cadherinGlioma cell linesGlioblastoma cellsN-mycSOX9E-cadherin
2010
Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells
Reddy E, Chettiar S, Kaur N, Shepal V, Shiras A. Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells. Experimental Cell Research 2010, 316: 2220-2236. PMID: 20595047, DOI: 10.1016/j.yexcr.2010.05.030.Peer-Reviewed Original ResearchConceptsDlxin-1MAGE homology domainCell survivalPC12 cellsPresence of NGFNeuronal differentiationDiverse cellular functionsMAGE family proteinsCell cycle progressionTranscriptional regulationHomology domainCellular functionsFamily proteinsNeuronal survivalDevelopmental apoptosisEnhanced neuritogenesisCycle progressionSignaling pathwaysMEK pathwayPharmacological inhibitorsCell deathAkt pathwayUnique regionAmino acidsEarly activation