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Michael Girardi, MD, FAAD

Vice Chair for Faculty Development and Scientific Innovation. Evans Professor of Dermatology; Director, Residency Program, Dermatology; Co-Director, T32 Research Fellowship Program, Dermatology

Contact Information

Michael Girardi, MD, FAAD

Patient Care Locations

Mailing Address

  • Dermatology

    PO Box 208059, 333 Cedar Street

    New Haven, CT 06520-8059

    United States



Clinical Expertise: Dr. Girardi is Co-Director of the Yale Cutaneous Lymphoma Group, Director of the Photopheresis Unit, and Director of the Phototherapy Unit at the Yale Comprehensive Cancer Center and Yale-New Haven Hospital. Dr. Girardi is also an active member of the national and international organizations (United States Cutaneous Lymphoma Consortium, International Society of Cutaneous Lymphoma) that formulate and publish the criteria guidelines for the diagnosis and treatment CTCL, and is executing the largest clinical database for CTCL. He has published over 150 scientific manuscripts, clinical reports, and book chapters, including on the genetic basis of CTCL and a Medical Progress Report for the New England Journal of Medicine. Dr. Girardi was awarded the 2023 Yale Blavatnik Innovation Award for the development of new treatments for T cell lymphoma and the 2017 Zeligman Award by Johns Hopkins University for his expertise in understanding the genetic and immunologic mechanisms that cause CTCL, and he has delivered over 100 national and international lectures including at the National Institutes of Health, U.S. Food and Drug Administration, Harvard University, University of Pennsylvania, Memorial Sloan Kettering Cancer Center, Moffitt Cancer Center, Kings College London, and Northwestern University. Dr. Girardi is currently Professor, Vice Chair, and NIH T32 Research Fellowship Co-Director for the Department of Dermatology, Yale School of Medicine.

Disease Interests: the diagnosis and management of cutaneous lymphoma and related conditions, including: mycosis fungoides (MF) cutaneous T cell lymphoma (CTCL) [variants of which include folliculotropic MF, follicular mucinosis MF, hypopigmented (hypomelanotic) MF, pagetoid reticulosis (Woringer-Kolopp disease), erythrodermic MF, tumor-stage (T3) MF, transformed MF (T-MF), large cell transformation MF (LCT-MF), and Sézary syndrome (SS)]; CD30+ lymphoproliferative disorders (CD30+ LPD) including lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL); CD4+ small/medium/pleomorphic T cell lymphoma (CD4+ SMPTCL); cutaneous B cell lymphoma (CBCL) [variants of which include primary cutaneous marginal zone B cell lymphoma (PCMZBCL) and primary cutaneous follicle center B cell lymphoma (PCFLBCL); lymphocytoma cutis (pseudolymphoma); parapsorias (including large plaque and small plaque variants); subcutaneous panniculitic T cell lymphoma (SCPTCL); cutaneous CD8+ cytotoxic T cell lymphoma; cutaneous gamma-delta T cell lymphoma; and cutaneous NK/T cell lymphoma. Laboratory Research: During more than 20 years leading an NCI-funded research program at Yale, Dr. Girardi’s laboratory is credited with major contributions to our understanding of skin biology immunology and skin cancer development, including the elucidation of roles for gamma-delta T cells, NKG2D ligands, Langerhans cells, and innate lymphoid cells. Dr. Girardi has served as the Co-Director for the Yale Comprehensive Cancer Center’s Immunology and Immunotherapy Program, and is the holder/filer of 10+ biomedical patents on cancer diagnosis and treatment and co-founder of two Yale startup companies: Stradefy Biosciences and Devana Bio. Dr. Girardi's work has been published in Science (x2), J Exp Med (x3), Nature, Nature Immunology (x4), Nature Genetics (x2), Nature Materials, PNAS (x4), and Blood (x4) – with a Google Scholar Profile of h-index 45+, i10-index 100+, 10,000+ citations. Watch a video with Dr. Michael Girardi >>

Dr. Girardi’s current research programs include:

  • The role of local immune cells in the development of cutaneous carcinogenesis. Using state-of-the-art genetically engineered mice, immunobiology techniques, and confocal imaging, the Girardi laboratory is dissecting how various immune cells, resident within and recruited to the skin, contribute the skin cancer development.
  • Novel approaches to the diagnosis and treatment of cutaneous T cell lymphoma (CTCL). Overseeing one of the largest centers for CTCL, Dr. Girardi and colleagues use genetic sequencing and robotic transfer to enhance diagnosis and to screen and develop new pharmaceutical agents in the treatment of this malignancy, and is engineer new small molecules and immunotherapeutics for T cell
  • Biodegradable nanotechnology in the prevention and treatment of skin cancer. In collaboration with W.M. Saltzman (Professor, Yale Biomedical Engineering) and Douglas Brash (Professor, Genetics), Dr. Girardi’s lab is developing novel strategies for skin cancer prevention and treatment.

Education & Training

  • Resident
    Yale University School of Medicine, New Haven, CT (1997)
  • Research Fellow
    Yale University School of Medicine, New Haven, CT (1997)
  • Research Fellow
    Yale University School of Medicine, New Haven, CT (1994)
  • Intern
    Yale-New Haven Hospital, New Haven, CT (1993)
  • MD
    Yale University (1992)
  • BS
    Brown University, Biology & Computer Science (1988)

Honors & Recognition

AwardAwarding OrganizationDate
Elected to the Association of American Physicians (AAP)Association of American Physicians (AAP)2023
The R. S. Evans Endowed ProfessorshipYale University2022
Catalyst Award for Cutaneous Lymphoma ResearchCutaneous Lymphoma Foundation2022
Yale Innovation Blavatnik AwardBlavatnik Fund2018, 2023
Pillar of ImmunologyJournal of Immunology2018
Spatz Foundation Award for Cutaneous LymphomaDrs. Martin & Dorothy Spatz Charitable Foundation2018
Zeligman Lectureship AwardJohns Hopkins University2017
Castle Connolly's Top Doctors AwardCastle Connolly2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023
Elected to the American Society of Clinical Investigation (ASCI)American Society of Clinical Investigation (ASCI)2009
Duhring Lectureship AwardUniversity of Pennsylvania2009
Award for “Exemplary Performance”Connecticut State Medical Society2007

Departments & Organizations