2019
Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Thomas T, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s7-s8. DOI: 10.1016/j.ijrobp.2019.06.392.Peer-Reviewed Original Research
2014
Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation
Wobb JL, Chen PY, Shah C, Moran MS, Shaitelman SF, Vicini FA, Mbah AK, Lyden M, Beitsch P. Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2014, 91: 312-318. PMID: 25446607, DOI: 10.1016/j.ijrobp.2014.09.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsBrachytherapyBreast NeoplasmsDose Fractionation, RadiationFemaleHumansMiddle AgedNeoplasm Recurrence, LocalNomogramsOrgan Sparing TreatmentsOutcome Assessment, Health CarePrognosisReproducibility of ResultsRisk AssessmentSensitivity and SpecificityUnited StatesConceptsLocoregional recurrencePartial breast irradiationConcordance indexBreast Surgeons MammoSite Registry TrialCox proportional hazards regression modelRisk of LRREarly-stage breast cancerProportional hazards regression modelsAccelerated Partial Breast IrradiationEstrogen receptor negativityBalloon-based brachytherapyHazards regression modelsWilliam Beaumont HospitalConformal radiation therapyBias-corrected indicesReceptor negativityRegistry trialClinicopathologic featuresPositive marginsClinicopathologic variablesBeaumont HospitalUnivariate analysisBreast cancerUse nomogramRadiation therapyNomogram for predicting the risk of locoregional recurrence in patients treated with accelerated partial-breast irradiation.
Wobb J, Chen P, Shah C, Moran M, Shaitelman S, Vicini F, Mbah A, Lyden M, Beitsch P. Nomogram for predicting the risk of locoregional recurrence in patients treated with accelerated partial-breast irradiation. Journal Of Clinical Oncology 2014, 32: 59-59. DOI: 10.1200/jco.2014.32.26_suppl.59.Peer-Reviewed Original ResearchLocoregional recurrenceC-indexCox proportional hazards regression modelRisk of LRREarly-stage breast cancerProportional hazards regression modelsStage breast cancerBalloon-based brachytherapyHazards regression modelsWilliam Beaumont HospitalPartial breast irradiationBias-corrected indicesRegistry trialClinicopathologic featuresER negativityPositive marginsClinicopathologic variablesBeaumont HospitalPerimenopausal statusUnivariate analysisBreast cancerUse nomogramConformal radiotherapyPatientsAPBI
2013
The Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy
Khan AJ, Parikh RR, Neboori HJ, Goyal S, Haffty BG, Moran MS. The Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy. The Breast Journal 2013, 19: 490-495. PMID: 23800027, DOI: 10.1111/tbj.12150.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalLocal relapse-free survivalUse of tamoxifenOverall survivalBreast relapseBreast cancerRadiation therapyOlder womenHormone receptor-positive breast carcinomaElderly breast cancer patientsNode-negative breast cancerEarly-stage breast cancerLow local recurrence rateInstitutional data baseIpsilateral breast relapseT1N0M0 breast cancerAdjuvant hormonal therapyAdjuvant radiation therapyBreast conserving surgeryContralateral breast cancerLocal recurrence rateBreast-conserving surgeryMetastasis-free survivalRelapse-free survivalBreast cancer patientsAre Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer?
Jones T, Neboori H, Wu H, Yang Q, Haffty BG, Evans S, Higgins S, Moran MS. Are Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer? Annals Of Surgical Oncology 2013, 20: 2866-2872. PMID: 23661183, PMCID: PMC5731457, DOI: 10.1245/s10434-013-2994-6.Peer-Reviewed Original ResearchConceptsNodal involvementClinicopathologic featuresSignificant associationStage I/II diseaseCancer subtypesDistant metastasis-free survivalEarly-stage breast cancerResultsThe study cohortAxillary node involvementBreast-conserving surgeryMetastasis-free survivalUseful prognostic variableBreast cancer subtypesAvailable tissue blocksNode involvementNode positivityNodal metastasisPathological reviewStudy cohortT stageTumor characteristicsTumor histologyTumor sizeProgesterone receptorSurgical assessment
2012
Association Between Tumor Molecular Subtype and Disease Presentation in Patients With Early-stage Breast Cancer
Jones T, Neboori H, Haffty B, Wu H, Yang Q, Moran M. Association Between Tumor Molecular Subtype and Disease Presentation in Patients With Early-stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s141. DOI: 10.1016/j.ijrobp.2012.07.164.Peer-Reviewed Original ResearchEarly-stage breast cancerTumor molecular subtypeDisease presentationBreast cancerMolecular subtypesPatientsCancerSubtypes
2011
The Prognostic Value of MDM2, MDM4 (MDMX), and p53 in Early Stage Breast Cancer Treated with Breast Conserving Surgery and Radiotherapy
Neboori H, Wu H, Schiff D, Goyal S, Moran M, Yang J, Hirshfield K, Haffty B. The Prognostic Value of MDM2, MDM4 (MDMX), and p53 in Early Stage Breast Cancer Treated with Breast Conserving Surgery and Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s62-s63. DOI: 10.1016/j.ijrobp.2011.06.126.Peer-Reviewed Original ResearchACR Appropriateness Criteria® Conservative surgery and Radiation – Stage I and II Breast Carcinoma
Bellon JR, Harris EE, Arthur DW, Bailey L, Carey L, Goyal S, Halyard MY, Horst KC, Moran MS, MacDonald SM, Haffty BG. ACR Appropriateness Criteria® Conservative surgery and Radiation – Stage I and II Breast Carcinoma. The Breast Journal 2011, 17: 448-455. PMID: 21790842, DOI: 10.1111/j.1524-4741.2011.01132.x.Peer-Reviewed Original ResearchConceptsRadiation therapySide effectsEarly-stage breast cancerLong-term side effectsAdjuvant radiation therapyAcute side effectsACR Appropriateness CriteriaWhole breast irradiationRisk of recurrenceAtherosclerotic heart diseasePartial breast irradiationMajority of womenConservative surgerySurvival benefitAppropriate patientsBreast conservationRandomized studyAppropriateness CriteriaHeart diseaseBreast carcinomaBreast cancerTherapyShort treatmentEffective alternativeTreatment
2010
Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy
Moran MS, Yang Q, Goyal S, Harris L, Chung G, Haffty BG. Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy. International Journal Of Radiation Oncology • Biology • Physics 2010, 81: 1236-1243. PMID: 21093162, DOI: 10.1016/j.ijrobp.2010.07.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceBiomarkers, TumorBlack PeopleBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapyTissue Array AnalysisVascular Endothelial Growth Factor AWhite PeopleConceptsEarly-stage breast cancerBreast-conserving therapyLocal relapse-free survivalRelapse-free survivalVascular endothelial growth factorEarly-stage breast cancer patientsLocal relapseBreast cancer patientsBreast cancerEndothelial growth factorVEGF expressionOverall survivalPrognostic valueCancer patientsTissue microarrayEstrogen receptor/progesterone receptor statusDistant metastasis-free survivalNodal relapse-free survivalGrowth factorProgesterone receptor statusInstitutional review board approvalMetastasis-free survivalLong-term outcomesMargin-negative patientsOverexpression of VEGFBreast Conservation Therapy and BRCA Status Do Not Predict for Poor Outcomes in Young Women with Early-stage Breast Cancer
Patel A, Goyal S, Moran M, Choi D, Haffty B. Breast Conservation Therapy and BRCA Status Do Not Predict for Poor Outcomes in Young Women with Early-stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s213. DOI: 10.1016/j.ijrobp.2010.07.513.Peer-Reviewed Original Research
2009
Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1
Sharma C, Harris L, Haffty BG, Yang Q, Moran MS. Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1. The Breast Journal 2009, 16: 193-196. PMID: 20030649, DOI: 10.1111/j.1524-4741.2009.00874.x.Peer-Reviewed Original ResearchConceptsBreast conservation therapyAA patientsWhite patientsWorse outcomesRadiation therapyAfrican American breast cancer patientsEarly-stage breast cancerAdjuvant chemotherapy regimensMedian radiation doseBreast cancer patientsLarge institutional seriesAfrican American patientsDate of treatmentChemotherapy regimenChemotherapy regimensSame radiation dosesChart reviewInstitutional seriesTherapy differsTreatment breaksConservation therapyCancer patientsBreast cancerMedian numberTreatment daysClinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy
Goyal S, Parikh RR, Green C, Schiff D, Moran MS, Yang Q, Haffty BG. Clinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 76: 679-684. PMID: 19464815, DOI: 10.1016/j.ijrobp.2009.02.050.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalHuman epidermal growth factor receptor 2Cause-specific survivalLower T stageMetastasis-free survivalBreast conservation therapyERCC-1 expressionERCC1 expressionAdjuvant chemotherapyHormonal therapyER positivityOverall survivalT stageConservation therapyProgesterone receptorBreast cancerEstrogen receptorNodal negativityRadiation therapyWorse distant metastasis-free survivalEarly-stage breast cancer patientsLocoregional recurrence-free survivalEarly-stage breast cancerEpidermal growth factor receptor 2Adjuvant hormonal therapy
2008
Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer
Moran MS, Yang Q, Harris LN, Jones B, Tuck DP, Haffty BG. Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer. Cancer 2008, 113: 2565-2574. PMID: 18816610, DOI: 10.1002/cncr.23881.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, MucinousAdultAntineoplastic AgentsBlack or African AmericanBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCohort StudiesCombined Modality TherapyFemaleFollow-Up StudiesHumansLymph NodesLymphatic MetastasisMastectomyNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapy DosageSurvival RateTreatment OutcomeWhite PeopleConceptsBreast conservation therapyLymph node recurrenceAA patientsWhite patientsAA womenNode recurrenceConservation therapyClinicopathologic differencesEarly-stage breast cancerChemotherapy/radiotherapyEarly-stage diseaseSurgical margin statusLong-term outcomesP53 expression statusBreast recurrenceOverall survivalIndependent predictorsLocal recurrenceLymph nodesMargin statusClinicopathologic featuresDistant metastasisN classificationMore estrogenBreast cancerBcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
Yang Q, Moran MS, Haffty BG. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. Breast Cancer Research And Treatment 2008, 115: 343. PMID: 18516673, DOI: 10.1007/s10549-008-0068-4.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerBreast conservation treatmentStage breast cancerBcl-2 expressionBreast cancerIpsilateral breast tumor recurrenceCox proportional hazards modelBreast tumor recurrenceIndependent prognostic factorProgesterone receptor statusOptimal treatment optionsBcl-2Proportional hazards modelBcl-2 antibodyApoptosis-related proteinsBreast recurrenceLocal relapseLocal recurrencePrognostic factorsReceptor statusClinical outcomesPrognostic significanceTreatment optionsTumor recurrencePrimary tumorOutcomes following breast conservation versus mastectomy in BRCA1/2 carriers with early-stage breast cancer
Pierce L, Griffith K, Buys S, Gaffney D, Haffty B, Moran M, Ben-David M, Garber J, Merajver S, Meirovitz A, Domchek S. Outcomes following breast conservation versus mastectomy in BRCA1/2 carriers with early-stage breast cancer. Journal Of Clinical Oncology 2008, 26: 536-536. DOI: 10.1200/jco.2008.26.15_suppl.536.Peer-Reviewed Original ResearchEarly-stage breast cancer
2007
Differences between African American (AA) and Caucasian (C) Patients Treated With Conservative Surgery and Radiation Therapy (CS+RT) for Early Stage Breast Cancer
Moran M, Harris L, Haffty B. Differences between African American (AA) and Caucasian (C) Patients Treated With Conservative Surgery and Radiation Therapy (CS+RT) for Early Stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s4-s5. DOI: 10.1016/j.ijrobp.2007.07.010.Peer-Reviewed Original Research
1997
Conservatively Treated Breast Cancer: Outcome by Histologic Subtype
Haffty B, Perrotta P, Ward B, Moran M, Beinfield M, McKhann C, Fischer D, Carter D. Conservatively Treated Breast Cancer: Outcome by Histologic Subtype. The Breast Journal 1997, 3: 7-14. DOI: 10.1111/j.1524-4741.1997.tb00134.x.Peer-Reviewed Original ResearchHistologic subtypeRecurrence-free rateRelapse rateDistant metastasisDuctal carcinomaRecurrence rateFocal invasionBreast cancerDistant recurrence-free survival rateIpsilateral breast tumor recurrence (IBTR) ratesIpsilateral breast tumor recurrenceRecurrence-free survival ratesDistant metastasis-free rateEarly-stage breast cancerSignificant differencesYale-New Haven HospitalPathological nodal involvementPrimary histologic subtypeBreast tumor recurrenceTumor recurrence rateBreast cancer patientsBreast conservation therapyMetastasis-free rateLow metastatic potentialAxillary dissection