2023
Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
Hirota R, Sasaki M, Honmou O, Yamashita T. Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects. Spine Surgery And Related Research 2023, 7: 319-326. PMID: 37636138, PMCID: PMC10447197, DOI: 10.22603/ssrr.2022-0234.Peer-Reviewed Original ResearchSpinal cord injuryMesenchymal stem cellsCord injuryMesenchymal stem cell transplantationSevere spinal cord injuryCentral nervous system diseaseMotor function recoveryStem cell transplantationNervous system diseasesSCI modelCell transplantationFunction recoveryIntravenous infusionMSC transplantationMotor functionRat modelIntravenous administrationSystem diseasesBone marrowSCI researchTransplantationInjuryRecent updatesStem cellsCell types
2011
Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments
Sasaki M, Lankford KL, Radtke C, Honmou O, Kocsis JD. Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments. Experimental Neurology 2011, 229: 88-98. PMID: 21281634, DOI: 10.1016/j.expneurol.2011.01.010.Peer-Reviewed Original ResearchConceptsCell transplantationDemyelinated spinal cord axonsMacrophage/microglia activationMost rodent modelsEndogenous myelin repairSpinal cord axonsNervous system repairMyelin-forming cellsMicroglia activationDemyelination modelDemyelinated lesionsLesion environmentActive demyelinationMyelin repairMyelin debrisRemyelination potentialInflammatory signalingRodent modelsLesion inductionRemyelinationExperimental remyelinationTransplantationTransplant studiesOECsHuman progenitors
2009
Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
Kocsis JD, Lankford KL, Sasaki M, Radtke C. Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury. Neuroscience Letters 2009, 456: 137-142. PMID: 19429149, PMCID: PMC2713444, DOI: 10.1016/j.neulet.2008.08.093.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryLow-affinity NGF receptorSchwann cell transplantationSignificant functional improvementSpinal cord resultsOlfactory receptor axonsPrecise cellular mechanismsCord resultsCell transplantationFunctional outcomeSynaptic contactsAxonal regenerationNasal mucosaFunctional improvementSpinal cordGlial cellsOlfactory bulbReceptor axonsTrophic supportNGF receptorAnimal modelsNeural repairTherapeutic candidateOECs
2005
28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons
Kocsis J, Sasaki M. 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons. 2005, 421-433. DOI: 10.1016/b978-012738761-1/50029-8.Peer-Reviewed Original ResearchTransplantation of SCsTransplantation of OECsSpinal cord injuryCentral nervous systemSchwann cellsAxonal regenerationBone marrow cellsFunctional recoveryMultiple sclerosisCell transplantationCord injurySpinal cordHind limb locomotor functionContusive spinal cord injuryBone marrow cell transplantationMarrow cellsSpinal cord injury modelMarrow cell transplantationCerebral ischemia modelSpinal cord resultsGlobal neuroprotectionDemyelination modelCord resultsFunctional outcomeDemyelinated axons
2002
Transplantation of human neural stem cells into the stroke model
Honmou O, Oka S, Sasaki M, Takahashi A, Tanooka A, Houkin K, Hashi K. Transplantation of human neural stem cells into the stroke model. Nosotchu 2002, 24: 355. DOI: 10.3995/jstroke.24.355.Peer-Reviewed Original ResearchHuman neural stem cellsNeural stem cellsStroke modelNeural stem cell transplantationStem cellsStem cell transplantationAdult mammalian brainExperimental animal modelsPossible therapeutic strategiesNeural productionIschemic lesionsIschemic volumeCell transplantationHistological examinationAdult brainTherapeutic strategiesAnimal modelsTransplantationGlial lineagesMammalian brainCell therapyFunctional benefitsMultipotential propertiesPresent reportStroke