2015
Preserving Genome Privacy in Research Studies
Wang S, Jiang X, Fox D, Ohno-Machado L. Preserving Genome Privacy in Research Studies. 2015, 425-441. DOI: 10.1007/978-3-319-23633-9_16.Peer-Reviewed Original ResearchGenome privacyPrivacy researchBetter privacy protectionObfuscation of dataSecure data repositoryLoss of privacyData use agreementsPrivacy challengesPrivacy problemsPrivacy protectionAttack modelIndividual privacyData sharingMassive collectionPrivacyData repositoryTraditional clinical informationScientific discoveryGenomic dataData analysis methodsBig challengeUse agreementsBiomedical communityTechnical aspects
2014
HUGO: Hierarchical mUlti-reference Genome cOmpression for aligned reads
Li P, Jiang X, Wang S, Kim J, Xiong H, Ohno-Machado L. HUGO: Hierarchical mUlti-reference Genome cOmpression for aligned reads. Journal Of The American Medical Informatics Association 2014, 21: 363-373. PMID: 24368726, PMCID: PMC3932469, DOI: 10.1136/amiajnl-2013-002147.Peer-Reviewed Original ResearchConceptsBase quality valuesCompression algorithmStorage savingsGenome compressionSequence Alignment/Map (SAM) formatCompression ratioNovel compression algorithmComparable compression ratioCompression mechanismK-means clusteringDifferent reference genomesQuality valuesDecompression qualityLossless compressionExecution timeCompression rateAligned readsMap formatAlgorithmBiomedical communityDifferent quality valuesExperimental datasetsAdaptive schemeStorage capabilityArchiving
2011
Translational bioinformatics: linking knowledge across biological and clinical realms
Sarkar I, Butte A, Lussier Y, Tarczy-Hornoch P, Ohno-Machado L. Translational bioinformatics: linking knowledge across biological and clinical realms. Journal Of The American Medical Informatics Association 2011, 18: 354-357. PMID: 21561873, PMCID: PMC3128415, DOI: 10.1136/amiajnl-2011-000245.Commentaries, Editorials and Letters