About
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Assistant Professor Adjunct
Research
Research at a Glance
Publications Timeline
A big-picture view of Lorenzo Galluzzi's research output by year.
29Publications
54Citations
Publications
A mitochondrial checkpoint to NF-κB signaling
Guilbaud E, Galluzzi L. A mitochondrial checkpoint to NF-κB signaling. Cell Death & Disease 2024, 15: 477. PMID: 38961079, PMCID: PMC11222492, DOI: 10.1038/s41419-024-06868-3.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDownstream of mitochondrial permeabilizationUbiquitination of mitochondrial proteinsApoptotic caspasesPermeabilized mitochondriaMitochondrial permeabilizationMitochondrial proteinsMitochondrial dysfunctionAutophagic disposalNF-kB activationInflammatory programCaspaseUbiquitinMitochondriaPermeabilizationInflammatory pathwaysProteinPathwaySerine Depletion Promotes Anti-Tumor Immunity by Activating Mitochondrial DNA-mediated cGAS-STING Signaling.
Saha S, Ghosh M, Li J, Wen A, Galluzzi L, Martinez L, Montrose D. Serine Depletion Promotes Anti-Tumor Immunity by Activating Mitochondrial DNA-mediated cGAS-STING Signaling. Cancer Research 2024 PMID: 38861367, DOI: 10.1158/0008-5472.can-23-1788.Peer-Reviewed Original ResearchConceptsAnti-tumor immunityImmune checkpoint inhibitors targeting PD-1Improved response to immune checkpoint inhibitorsCheckpoint inhibitors targeting PD-1Infiltration of immune effector cellsSuppressors of anti-tumor immunityColorectal cancerResponse to immune checkpoint inhibitorsEnhance tumor immunogenicityI interferonImmune checkpoint inhibitorsT-cell depletionCancer metabolismSerine deprivationImmune effector cellsSensitivity of tumorsType I IFN signalingAnti-neoplastic effectsImmune-enhancing effectsDisrupted metabolic pathwaysColorectal cancer cellsType I interferonCheckpoint inhibitorsIntratumoral infiltrationPD-1PARP7 and nucleic acid-driven oncosuppression
Naulin F, Guilbaud E, Galluzzi L. PARP7 and nucleic acid-driven oncosuppression. Cellular & Molecular Immunology 2024, 1-3. PMID: 38834655, DOI: 10.1038/s41423-024-01182-6.Peer-Reviewed Original ResearchAltmetricCOX2-dependent suppression of anticancer immunity
Lira M, Galluzzi L, Vanpouille-Box C. COX2-dependent suppression of anticancer immunity. Trends In Cancer 2024, 10: 573-575. PMID: 38821853, PMCID: PMC11236508, DOI: 10.1016/j.trecan.2024.05.006.Peer-Reviewed Original ResearchAltmetricConceptsInterleukin-2Tumor-targeting immune responsesPromote tumor progressionProstaglandin E<sub>2</sub>Inhibition of mitochondrial metabolismDownregulation of interleukin 2Cancer cell proliferationAnticancer immunityT cellsTumor progressionImmune responseCell proliferationMitochondrial metabolismProstaglandinCancerAuthor Correction: Cancer cell metabolism and antitumour immunity
De Martino M, Rathmell J, Galluzzi L, Vanpouille-Box C. Author Correction: Cancer cell metabolism and antitumour immunity. Nature Reviews Immunology 2024, 24: 537-537. PMID: 38806693, DOI: 10.1038/s41577-024-01051-3.Peer-Reviewed Original ResearchAltmetricCancer cell metabolism and antitumour immunity
De Martino M, Rathmell J, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nature Reviews Immunology 2024, 1-16. PMID: 38649722, DOI: 10.1038/s41577-024-01026-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell-extrinsic mechanismsCancer cell-extrinsic mechanismsCancer cell-intrinsicAntitumour immune responseAdverse microenvironmental conditionsIncreased proliferative potentialAccelerated disease progressionAdaptive immune functionMetabolic rewiringAnticancer immunityMalignant cellsAlteration of metabolismTumor progressionCell-intrinsicMicroenvironmental conditionsDisease progressionProliferative potentialImmune responseCancer cellsImmune functionTherapeutic purposesCancerAlterationsCellsTumorInflammation and mitophagy are mitochondrial checkpoints to aging
Guilbaud E, Sarosiek K, Galluzzi L. Inflammation and mitophagy are mitochondrial checkpoints to aging. Nature Communications 2024, 15: 3375. PMID: 38643254, PMCID: PMC11032393, DOI: 10.1038/s41467-024-47840-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsTargeting immunogenic cell stress and death for cancer therapy
Galluzzi L, Guilbaud E, Schmidt D, Kroemer G, Marincola F. Targeting immunogenic cell stress and death for cancer therapy. Nature Reviews Drug Discovery 2024, 23: 445-460. PMID: 38622310, PMCID: PMC11153000, DOI: 10.1038/s41573-024-00920-9.Peer-Reviewed Original ResearchCitationsAltmetricConceptsImmunogenic cell deathTherapeutic strategiesImmunogenic cell death inducerImmunologically cold tumorsConventional therapeutic strategiesCell deathCancer cell biologyICD inducersCold tumorsAnticancer treatmentCancer therapyCancerCell stressDeathTreatmentCell biologyTranslational effortsImmunotherapyDiscovery platformTumorTherapyInducerLesionsImmunologyImmunological aspects of central neurodegeneration
Niso-Santano M, Fuentes J, Galluzzi L. Immunological aspects of central neurodegeneration. Cell Discovery 2024, 10: 41. PMID: 38594240, PMCID: PMC11004155, DOI: 10.1038/s41421-024-00666-z.Peer-Reviewed Original ResearchAltmetricConceptsCentral neurodegenerationImmune effector cellsTarget immune cellsHuntington's diseaseNeuronal defectsCentral nervous systemEffector cellsImmunological dysfunctionAlzheimer's diseaseNeurodegenerative disordersImmune cellsImmunological mechanismsImmunological aspectsTherapeutic strategiesClinically relevant neuroprotective effectsNeuronal populationsNeurodegenerative conditionsNervous systemNeuroprotective effectsDiseaseNeurodegenerative syndromeTherapeutic purposesNeurodegenerationParkinson's diseaseCellsLive Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids.
Charpentier M, Bloy N, Formenti S, Galluzzi L, Demaria S. Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids. Journal Of Visualized Experiments 2024 PMID: 38647326, DOI: 10.3791/66680.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPatient-derived tumor organoidsClonogenic assayRadiation therapyTumor organoidsCancer cellsIrradiated cancer cellsMeasure of radiosensitivityClinical cancer managementNon-irradiated (controlDose-dependent mannerSingle-cell suspensionsMalignant cellsTumor modelCancer managementCellular radiosensitivitySensitive to irradiationComplex tumor modelsOxidative DNA damageRepair oxidative DNA damageCancer typesDelayed mannerIonizing raysSingle-cell dissociationFlow cytometry-Radiosensitivity