Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells
Yang YQ, Dong WJ, Yin XF, Xu YN, Yang Y, Wang JJ, Yuan SJ, Xiao J, DeLong JH, Chu L, Xu HN, Zhou XM, Wang RW, Fang L, Liu XY, Zhang KJ. Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells. Protein & Cell 2016, 7: 538-543. PMID: 27295261, PMCID: PMC4930771, DOI: 10.1007/s13238-016-0281-6.Peer-Reviewed Original ResearchInterferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells
Yang Y, DeLong J, Zhang K. Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells. Single Cell Biology 2016, 5: 1-2. DOI: 10.4172/2168-9431.1000146.Peer-Reviewed Original ResearchPD-L1Immune cellsAnti-PD-1 antibodyTumor microenvironmentTumor cellsPD-L1 expressionT effector cellsProliferation of CD8Receptor PD-1Immune checkpoint proteinsB7-H1PD-1Effector cellsCancer immunotherapyImmune responseSmall molecule inhibitorsInhibitory signalsClinical drugsMolecule inhibitorsCellsMicroenvironmentCD8ImmunotherapyCheckpoint proteinsCD274