Jonathan DeLong, PhD
Postdoctoral AssociateDownloadHi-Res Photo
About
Titles
Postdoctoral Associate
Biography
Jonathan completed his PhD in the lab of Dr. Chris Hunter at the University of Pennsylvania. His thesis work helped establish the cytokine IL-27 as a critical driver of inhibitory receptor expression, important in limiting T cell-mediated immunopathology as well as limiting productive anti-tumor responses.
In the Sansing lab, he is studying the endogenous signals that control inflammation and wound healing following hemorrhagic stroke. One major focus is on the immunomodulatory effects of cholesterol. Previous studies have demonstrated compelling effects of cholesterol on the macrophage response to LPS. Jonathan aims to expand on these observations, developing a broader model to understand the roles of cholesterol uptake in macrophage function, with a focus on sterile inflammation.
Appointments
Departments & Organizations
Education & Training
- PhD
- University of Pennsylvania, Immunology (2018)
- BS
- University of Washington, Biochemistry (2007)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jonathan DeLong's published research.
Publications Timeline
A big-picture view of Jonathan DeLong's research output by year.
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Kevin O'Connor, PhD
34Publications
1,591Citations
Publications
2023
Role of Inflammatory Processes in Hemorrhagic Stroke
Ohashi S, DeLong J, Kozberg M, Mazur-Hart D, van Veluw S, Alkayed N, Sansing L. Role of Inflammatory Processes in Hemorrhagic Stroke. Stroke 2023, 54: 605-619. PMID: 36601948, DOI: 10.1161/strokeaha.122.037155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsHemorrhagic strokeIntracerebral hemorrhageInflammatory processCerebral amyloid angiopathy-related haemorrhageAngiopathy-related hemorrhageRole of inflammationCerebral amyloid angiopathyInflammatory immune responseEffective therapeutic strategyCentral nervous systemBrain residentAmyloid angiopathyImmune cellsTissue injuryCommon causeImmune responseHemorrhageTherapeutic strategiesNervous systemMajor subtypesDisease pathologyStrokeOlder individualsTissue recoveryDeadliest form
2022
Inflammatory Responses After Ischemic Stroke
DeLong JH, Ohashi SN, O’Connor K, Sansing LH. Inflammatory Responses After Ischemic Stroke. Seminars In Immunopathology 2022, 44: 625-648. PMID: 35767089, DOI: 10.1007/s00281-022-00943-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsPD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Perry J, Shallberg L, Clark J, Gullicksrud J, DeLong J, Douglas B, Hart A, Lanzar Z, O’Dea K, Konradt C, Park J, Kuchroo J, Grubaugh D, Zaretsky A, Brodsky I, Malefyt R, Christian D, Sharpe A, Hunter C. PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 2022, 23: 743-756. PMID: 35437326, PMCID: PMC9106844, DOI: 10.1038/s41590-022-01170-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPD-1ETreg cellsPD-L1Interleukin-10T cellsCell expressionInhibitory receptor PD-1Regulatory T cell populationDevelopment of immunopathologyTreg cell populationRegulatory T cellsEffector T cellsPD-1 interactionReceptor PD-1T cell populationsCell populationsMyeloid cell expressionT cell receptor activationLineage-specific deletionTreg cellsEffector phenotypeInfected miceCell receptor activationInflammatory processEarly interferon
2021
Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain
Chang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, DeLong JH, Hammond MD, Massey J, Landreneau M, Love JC, Sansing LH. Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain. Stroke 2021, 52: 1798-1808. PMID: 33840225, PMCID: PMC8085165, DOI: 10.1161/strokeaha.120.032196.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMonocyte-derived macrophagesIntracerebral hemorrhageT cell proliferationCore transcriptional programDifferential gene expressionDistinct transcriptional signaturesBone marrow-derived macrophagesAntigen-specific T cell proliferationTranscriptional programsCD4 T cell proliferationLongitudinal transcriptomic analysisVivo phagocytosis assaysTranscriptomic analysisDivergent functionsMarrow-derived macrophagesMHCII genesTissue-resident microgliaAntigen-presenting capabilityAutologous blood injectionGene expressionPrimary microglia culturesInnate immune cellsPhagocytosis of debrisTranscriptional signatureBlood-derived macrophagesLeukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Goods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH, Investigators T. Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu. JCI Insight 2021, 6: e145857. PMID: 33749664, PMCID: PMC8026179, DOI: 10.1172/jci.insight.145857.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntracerebral hemorrhageAcute brain injurySystemic immune responsesBrain tissue injuryHigh mortality rateLocal cellular responseAcute injuryTreatment optionsIntracerebral eventsBrain injuryCerebral hematomaLeukocyte responseTissue injuryT cellsImmune responseCT scanMortality rateDevastating formImmune dynamicsTherapeutic interventionsLeukocyte dynamicsBrain tissuePatientsInvasive surgeryInjury
2020
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA. Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. The Journal Of Immunology 2020, 205: 377-386. PMID: 32522836, PMCID: PMC7368461, DOI: 10.4049/jimmunol.1901463.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChronic kidney diseaseUnilateral ureteral obstructionIL-17AIL-27RαIL-27Ureteral obstructionKidney diseaseIL-27 actsImmune cell infiltratesCytokine IL-27Day of surgeryImmune-mediated pathologyTubular epithelial cellsDegree of injuryFibrosis AssociatedKidney injuryTh17 cellsTh17 responsesCell infiltrateSerum levelsInflammatory cascadeRenal fibrosisIL-17RAImmune cellsChemokine mRNA
2019
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis.
Park J, DeLong JH, Knox JJ, Konradt C, Wojno EDT, Hunter CA. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Infection And Immunity 2019, 87 PMID: 31548322, PMCID: PMC6867838, DOI: 10.1128/iai.00455-19.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsIL-27p28IL-27Parasite-specific antibody titersEffector T cell populationsT cell-mediated pathologyCell-mediated pathologyT cell activityReduced parasite burdenT cell populationsB cell responsesCentral nervous systemInterleukin-27Antibody titersMajor inhibitory effectHeterodimeric cytokineParasite replicationImmune serumNervous systemParasite burdenCell responsesCell activityInhibitory effectIntracellular parasitesCell populationsToxoplasmosisIL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors
DeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. ImmunoHorizons 2019, 3: 13-25. PMID: 31356173, PMCID: PMC6994206, DOI: 10.4049/immunohorizons.1800083.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsB7-H1 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCostimulatory and Inhibitory T-Cell ReceptorsCTLA-4 AntigenFemaleInterleukinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-CellReceptors, ImmunologicSpleenToxoplasmaToxoplasmosisTranscriptomeTransfectionConceptsT cell expressionMultiple inhibitory receptorsIL-27Inhibitory receptorsPD-L1LAG-3Cell expressionCTLA-4Effector cell expressionTCR stimulationEffector T cellsIL-27 productionT cell activationTim-3Cell surface moleculesCell-extrinsic factorsT cellsIR expressionCell activationTIGITInfectionTCR signalsSurface moleculesSynergistic inductionVivo overexpression
2018
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.
DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. The Journal Of Immunology 2018, 200: 1761-1770. PMID: 29358280, PMCID: PMC5821564, DOI: 10.4049/jimmunol.1701154.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsT cell expressionIL-27T cellsEffector cellsSca-1Cell expressionPathogen-specific T cellsMemory precursor effector cellsEndogenous IL-27Identification of CD8Type I IFNMemory stem cellsCytokine-mediated signalsEffector CD4Ly6C expressionSca-1 expressionImmune populationsT-betExpression of Ly6CMemory populationMouse CD4I IFNLy6CIFNMouse splenocytes
2017
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Science Translational Medicine 2017, 9 PMID: 28768806, PMCID: PMC5987220, DOI: 10.1126/scitranslmed.aam9171.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cellsType 2 helper T cellsDisease-causing T cellsHuman memory THelper T cellsInflammatory response pathwaysClinical responseAllergic disordersAtopic individualsImmunomodulatory strategiesAllergic diseasesMemory TCell subsetsUseful biomarkerTherapeutic targetCell signatureCell subpopulationsPathogenic responsesDisease-related phenotypesCell typesCellsDistinct pathwaysCD161CD4Immunotherapy