2022
Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study)
Berg C, Patel B, Reynolds M, Tuzovic M, Chew K, Sico J, Bhattacharya D, Butt A, Lim J, Bedimo R, Brown S, Gottdiener J, Warner A, Freiberg M, So-Armah K, Nguyen K. Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study). The American Journal Of Cardiology 2022, 186: 50-57. PMID: 36343446, PMCID: PMC10193525, DOI: 10.1016/j.amjcard.2022.10.035.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionDiastolic functionAtrial mechanicsLA strainHuman immunodeficiency virus (HIV) infectionLogistic regressionCross-sectional cohort analysisCohort of PLWHHIV uninfected controlsLA conduit strainLA phasic strainLA reservoir strainLeft Atrial MechanicsLV diastolic dysfunctionHIV viral loadHIV viral suppressionImmunodeficiency virus infectionVentricular diastolic functionHuman immunodeficiency virusPropensity weightingPLWH cohortSubclinical cardiomyopathyAntiretroviral therapyCardiovascular deathViral suppressionCharacteristics and Gender Differences of Headache in the Veterans Health Administration
Sico JJ, Seng E, Wang K, Skanderson M, Schindler E, Ney JP, Lorenze N, Kimber A, Lindsey H, Grinberg AS, Kuruvilla D, Higgins D, Graham G, Sandbrink F, Scholten J, Shapiro RE, Lipton RB, Fenton B. Characteristics and Gender Differences of Headache in the Veterans Health Administration. Neurology 2022, 99: e1993-e2005. PMID: 36100437, PMCID: PMC9651459, DOI: 10.1212/wnl.0000000000200905.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisHealthcare utilizationIncidence rateHeadache careHeadache typesHealth AdministrationSociodemographic characteristicsMilitary-related exposuresAge-adjusted incidenceEmergency department utilizationElectronic health record dataRetrospective cohort designType of headacheHigh incidence rateTraumatic brain injuryUnited States veteransHealth record dataPost-traumatic stress disorderGender differencesMilitary sexual traumaHeadache disordersBrain injuryHeadache specialistsCohort designFrequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine
Seng EK, Fenton BT, Wang K, Lipton RB, Ney J, Damush T, Grinberg AS, Skanderson M, Sico JJ. Frequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine. Neurology 2022, 99: e1979-e1992. PMID: 36100439, PMCID: PMC9651466, DOI: 10.1212/wnl.0000000000200888.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHealth care utilizationStudy periodCare utilizationHealth AdministrationOne-year period prevalenceOverweight/obesityMental health disordersChi-square testStudent's t-testMilitary sexual traumaAnnual encountersHeadache comorbidityPain comorbiditiesCohort entryCommon comorbiditiesPain disordersTotal cohortAnnual incidenceHealthcare utilizationHigher proportionPeriod prevalenceEmergency departmentMigraine carePrimary careMilitary sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women
Gaffey AE, Rosman L, Sico JJ, Haskell SG, Brandt CA, Bathulapalli H, Han L, Dziura J, Skanderson M, Burg MM. Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women. Journal Of Hypertension 2022, 40: 2307-2315. PMID: 35983872, DOI: 10.1097/hjh.0000000000003267.Peer-Reviewed Original ResearchConceptsIncident hypertensionRisk factorsPsychiatric disordersMultivariate Cox proportional hazards modelVeterans Health Administration dataGreater riskCox proportional hazards modelTrauma-related psychiatric disordersMiddle-aged veteransCardiovascular risk factorsBaseline blood pressureElevated cardiovascular riskLarge prospective cohortHealth Administration dataMiddle-aged menProportional hazards modelSex-specific analysesPosttraumatic stress disorderMilitary sexual traumaCardiovascular riskCohort studyProspective cohortBlood pressureTreatment attenuatesCardiovascular impactPairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design
Miech EJ, Perkins AJ, Zhang Y, Myers LJ, Sico JJ, Daggy J, Bravata DM. Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design. BMJ Open 2022, 12: e061469. PMID: 35672067, PMCID: PMC9174826, DOI: 10.1136/bmjopen-2022-061469.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaCohort StudiesHealth Services ResearchHumansIschemic Attack, TransientStrokeConceptsTransient ischemic attackLogistic regression modelsHealth services researchSet of patientsOverall sample prevalenceObservational cohortLogistic regressionSample prevalenceRecurrent ischemic strokeVeterans Affairs hospitalRegression modelsServices researchIschemic attackRecurrent strokeCause mortalityCombined endpointIschemic strokePatient outcomesDeath outcomesCare outcomesPatientsSecondary analysisPrevalenceOutcomesCohort
2021
Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study
Sico JJ, Kundu S, So‐Armah K, Gupta SK, Chang C, Butt AA, Gibert CL, Marconi VC, Crystal S, Tindle HA, Freiberg MS, Stewart JC. Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study. Journal Of The American Heart Association 2021, 10: e017637. PMID: 34169726, PMCID: PMC8403311, DOI: 10.1161/jaha.119.017637.Peer-Reviewed Original ResearchConceptsHIV-positive peopleBaseline antidepressant useCerebrovascular risk factorsRisk of strokeRisk factorsAlcohol use disorderStroke riskAntidepressant useUse disordersCocaine useSociodemographic characteristicsTraditional cerebrovascular risk factorsVeterans Aging Cohort StudyCox proportional hazards modelBackground HIV infectionHIV-specific factorsIndividual antiretroviral agentsAntiretroviral therapy useBaseline cardiovascular diseaseIndependent risk factorAging Cohort StudyIschemic stroke riskHIV-positive veteransProportional hazards modelUninfected veteransHospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence
Levine DA, Perkins AJ, Sico JJ, Myers LJ, Phipps MS, Zhang Y, Bravata DM. Hospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence. Stroke 2021, 52: 2371-2378. PMID: 34039034, PMCID: PMC8238890, DOI: 10.1161/strokeaha.120.031721.Peer-Reviewed Original ResearchConceptsIschemic stroke incidenceStroke incidenceHospital factorsPhysician staffingTIA patientsHypertension controlProcess measuresModerate potency statinTransient ischemic attackDays of dischargeEmergency department dischargeVeterans Affairs hospitalEligible patientsIschemic attackStatin useAntithrombotic useEmergency departmentEmergency physiciansInpatient unitDay 2HospitalPatient volumeFiscal year 2015PatientsIncidence
2020
Posttraumatic Stress Disorder, Antidepressant Use, and Hemorrhagic Stroke in Young Men and Women
Gaffey AE, Rosman L, Burg MM, Haskell SG, Brandt CA, Skanderson M, Dziura J, Sico JJ. Posttraumatic Stress Disorder, Antidepressant Use, and Hemorrhagic Stroke in Young Men and Women. Stroke 2020, 52: 121-129. PMID: 33297868, PMCID: PMC7770089, DOI: 10.1161/strokeaha.120.030379.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHemorrhagic strokeHealth care utilizationUse of SSRIsGreater riskSSRI useStroke riskCare utilizationStress disorderEffects of PTSDIncident hemorrhagic strokeMiddle-aged veteransModifiable risk factorsNon-pharmacological treatmentMultivariate Cox modelNorepinephrine reuptake inhibitorsOverall incidence rateHemorrhagic stroke riskSNRI useIncident strokeAntidepressant useReuptake inhibitorsComorbid conditionsLifestyle factorsPsychiatric comorbidityCommunity‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV
Zifodya JS, Duncan MS, So‐Armah K, Attia EF, Akgün KM, Rodriguez‐Barradas M, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Hoo G, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice AC, Freiberg MS, Crothers K. Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV. Journal Of The American Heart Association 2020, 9: e017645. PMID: 33222591, PMCID: PMC7763776, DOI: 10.1161/jaha.120.017645.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCVD risk factorsCVD eventsRisk factorsCAP severityHIV infectionHIV statusSevere community-acquired pneumoniaVeterans Aging Cohort StudyIncident CVD eventsCardiovascular disease eventsMultivariable-adjusted modelsAging Cohort StudyCox regression analysisDate of admissionMultivariable-adjusted analysesHigher mortality riskBackground HospitalizationCAP hospitalizationsHIV-uninfectedCardiovascular eventsIncident CVDCohort studyCVD riskUS veteransReason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study
McGeary DD, Resick PA, Penzien DB, Eapen BC, Jaramillo C, McGeary CA, Nabity PS, Peterson AL, Young-McCaughan S, Keane TM, Reed D, Moring J, Sico JJ, Pangarkar SS, Houle TT. Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study. Cephalalgia 2020, 40: 1155-1167. PMID: 32867535, DOI: 10.1177/0333102420953109.Peer-Reviewed Original ResearchConceptsMechanism of injuryHead injuryPre-existing migraineHeadache onsetProportion of veteransHeadache phenotypeCohort studyPosttraumatic headacheICHD-3 diagnostic criteriaMild traumatic injuryProportion of participantsSignificant differencesPercent of participantsPersistent headacheICHD-3Onset groupTraumatic injuryInclusion criteriaTreatment-seeking veteransPsychiatric symptomsMild TBIDiagnostic criteriaHeadacheSurvival analysisInjuryPrevalence of and characteristics associated with in-hospital mortality in a Ugandan neurology ward
Diaz MM, Hu X, Fenton BT, Kimuli I, Lee A, Lindsey H, Bigelow JK, Maiser S, Altalib HH, Sico JJ. Prevalence of and characteristics associated with in-hospital mortality in a Ugandan neurology ward. BMC Neurology 2020, 20: 42. PMID: 32005185, PMCID: PMC6995141, DOI: 10.1186/s12883-020-1627-5.Peer-Reviewed Original ResearchConceptsNeurology wardHead traumaHospital mortalityWorse survivalCommon diagnosisMultivariate Cox proportional hazard modelingSub-Saharan African hospitalsCox proportional hazard modelingKaplan-Meier survival curvesConclusionsIn-hospital mortalityPatient-level predictorsHigh-risk groupProportional hazard modelingDiagnosis of infectionTime of deathIndex hospitalizationHospital admissionMulago HospitalNeurologic illnessAfrican hospitalsNeurologic diseaseSurvival curvesPatientsHazard modelingMortality
2018
Quality of Care for Veterans With Transient Ischemic Attack and Minor Stroke
Bravata DM, Myers LJ, Arling G, Miech EJ, Damush T, Sico JJ, Phipps MS, Zillich AJ, Yu Z, Reeves M, Williams LS, Johanning J, Chaturvedi S, Baye F, Ofner S, Austin C, Ferguson J, Graham GD, Rhude R, Kessler CS, Higgins DS, Cheng E. Quality of Care for Veterans With Transient Ischemic Attack and Minor Stroke. JAMA Neurology 2018, 75: 419-427. PMID: 29404578, PMCID: PMC5885264, DOI: 10.1001/jamaneurol.2017.4648.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMinor strokeEmergency departmentElements of careDay 2Ischemic attackDay 7Federal fiscal year 2014Intensive care unit stayDeep vein thrombosis prophylaxisVeterans Health Administration systemCare qualityReceipt of thrombolysisRecurrent vascular eventsStroke care qualityVHA emergency departmentGuideline-concordant careLength of stayGuideline-recommended processesProcess of careHealth Administration systemQuality of careHemoglobin A1c measurementsElectronic quality measuresHealth care systemAssociation of Human Immunodeficiency Virus Infection and Risk of Peripheral Artery Disease
Beckman JA, Duncan MS, Alcorn CW, So-Armah K, Butt AA, Goetz M, Tindle HA, Sico J, Tracy RP, Justice AC, Freiberg MS. Association of Human Immunodeficiency Virus Infection and Risk of Peripheral Artery Disease. Circulation 2018, 138: 255-265. PMID: 29535090, PMCID: PMC6050082, DOI: 10.1161/circulationaha.117.032647.Peer-Reviewed Original ResearchConceptsRisk of PADIncident PAD eventsPeripheral artery diseaseHuman immunodeficiency virusCD4 cell countTraditional atherosclerotic risk factorsPAD risk factorsAtherosclerotic risk factorsPAD eventsRisk factorsCell countUninfected veteransCD4 cellsArtery diseaseHIV infectionHIV statusViral loadCells/Peripheral artery disease eventsPrior peripheral artery diseaseHuman immunodeficiency virus (HIV) infectionVeterans Aging Cohort StudyHIV-1 ribonucleic acidHIV infection statusHIV viral loadPost‐stroke hypertension control and receipt of health care services among veterans
Kohok DD, Sico JJ, Baye F, Myers L, Coffing J, Kamalesh M, Bravata DM. Post‐stroke hypertension control and receipt of health care services among veterans. Journal Of Clinical Hypertension 2018, 20: 382-387. PMID: 29397583, PMCID: PMC8031130, DOI: 10.1111/jch.13194.Peer-Reviewed Original ResearchConceptsPrimary careHypertension managementRecurrent stroke rateGoal blood pressureRetrospective cohort studyAcute ischemic strokeIschemic stroke patientsIschemic stroke admissionsFuture intervention studiesHealth care servicesBP controlBP trajectoriesPC visitsGoal BPHypertension controlStroke admissionsCohort studyIschemic strokeBlood pressureMean BPHealthcare utilizationMedian timeStroke patientsStroke ratePatients
2016
Using Radiological Data to Estimate Ischemic Stroke Severity
Sico JJ, Phipps MS, Concato J, Brandt C, Wells CK, Lo AC, Nadeau SE, Williams LS, Gorman M, Boice JL, Bravata DM. Using Radiological Data to Estimate Ischemic Stroke Severity. Journal Of Stroke And Cerebrovascular Diseases 2016, 25: 792-798. PMID: 26794264, DOI: 10.1016/j.jstrokecerebrovasdis.2015.12.002.Peer-Reviewed Original ResearchConceptsStroke severityHospital mortalityStroke patientsC-statisticAcute ischemic stroke patientsStroke care qualityIschemic stroke patientsChart review dataIschemic stroke severityElectronic health recordsAdmission headSevere strokePoststroke mortalityAbnormal findingsValid measurePatient levelRadiographic scoresRadiological dataRadiographic dataRadiographic measuresCare qualityRisk adjustmentSeverityHealth recordsMortality
2015
HIV status and the risk of ischemic stroke among men
Sico J, Chang C, So-Armah K, Justice A, Hylek E, Skanderson M, McGinnis K, Kuller L, Kraemer K, Rimland D, Bidwell Goetz M, Butt A, Rodriguez-Barradas M, Gibert C, Leaf D, Brown S, Samet J, Kazis L, Bryant K, Freiberg M, Chang C, So-Armah K, Justice A, Hylek E, Skanderson M, McGinnis K, Kuller L, Kraemer K, Rimland D, Goetz M, Butt A, Rodriguez Barradas M, Gibert C, Leaf D, Brown S, Samet J, Kazis L, Bryant K, Freiberg M. HIV status and the risk of ischemic stroke among men. Neurology 2015, 84: 1933-1940. PMID: 25862803, PMCID: PMC4433456, DOI: 10.1212/wnl.0000000000001560.Peer-Reviewed Original ResearchConceptsIschemic stroke riskVeterans Aging Cohort Study Virtual CohortIschemic stroke risk factorsStroke risk factorsHIV infectionUninfected veteransIschemic strokeStroke riskMale veteransComorbid diseasesRisk factorsSubstance useBaseline cardiovascular diseaseIschemic stroke rateRace/ethnicityHIV biomarkersMedian followStroke eventsHIV statusCardiovascular diseaseStroke rateClinical sitesHIVInfectionStroke
2013
Prehypertension, Hypertension, and the Risk of Acute Myocardial Infarction in HIV-Infected and -Uninfected Veterans
Armah KA, Chang CC, Baker JV, Ramachandran VS, Budoff MJ, Crane HM, Gibert CL, Goetz MB, Leaf DA, McGinnis KA, Oursler KK, Rimland D, Rodriguez-Barradas MC, Sico JJ, Warner AL, Hsue PY, Kuller LH, Justice AC, Freiberg MS, Team F. Prehypertension, Hypertension, and the Risk of Acute Myocardial Infarction in HIV-Infected and -Uninfected Veterans. Clinical Infectious Diseases 2013, 58: 121-129. PMID: 24065316, PMCID: PMC3864500, DOI: 10.1093/cid/cit652.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAMI riskElevated BPMyocardial infarctionUninfected peopleVeterans Aging Cohort Study Virtual CohortIncident acute myocardial infarctionRisk of AMICox proportional hazards regressionBlood pressure goalsCohort of HIVJoint National CommitteeHigh blood pressureHuman immunodeficiency virusProportional hazards regressionRace/ethnicityHypertensive BPVACS-VCBlood pressureHIV statusNormotensive individualsHazards regressionImmunodeficiency virusBP categoriesSeventh ReportHIV Infection and the Risk of Acute Myocardial Infarction
Freiberg MS, Chang CC, Kuller LH, Skanderson M, Lowy E, Kraemer KL, Butt AA, Goetz M, Leaf D, Oursler KA, Rimland D, Barradas M, Brown S, Gibert C, McGinnis K, Crothers K, Sico J, Crane H, Warner A, Gottlieb S, Gottdiener J, Tracy RP, Budoff M, Watson C, Armah KA, Doebler D, Bryant K, Justice AC. HIV Infection and the Risk of Acute Myocardial Infarction. JAMA Internal Medicine 2013, 173: 614-622. PMID: 23459863, PMCID: PMC4766798, DOI: 10.1001/jamainternmed.2013.3728.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAcute myocardial infarctionRisk of AMIFramingham risk factorsUninfected veteransRisk factorsMyocardial infarctionAMI eventsHIV statusVeterans Aging Cohort Study Virtual CohortHIV-1 RNA levelsStandard Framingham risk factorsIncident acute myocardial infarctionIncidence of AMISubstance useBaseline cardiovascular diseaseCD4 cell countHepatitis C infectionBody mass indexHIV-1 RNACopies/mLHIV-positive veteransTime-updated analysisDecade of ageRace/ethnicity
2011
Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source
McGinnis KA, Brandt CA, Skanderson M, Justice AC, Shahrir S, Butt AA, Brown ST, Freiberg MS, Gibert CL, Goetz MB, Kim JW, Pisani MA, Rimland D, Rodriguez-Barradas MC, Sico JJ, Tindle HA, Crothers K. Validating Smoking Data From the Veteran’s Affairs Health Factors Dataset, an Electronic Data Source. Nicotine & Tobacco Research 2011, 13: 1233-1239. PMID: 21911825, PMCID: PMC3223583, DOI: 10.1093/ntr/ntr206.Peer-Reviewed Original ResearchConceptsSmoking statusHealth factorsSmoking dataKappa statisticsSmoking variablesVeterans Aging Cohort StudyAging Cohort StudySelf-reported smoking dataCohort studyCurrent smokersSmoking interventionsVirtual cohortElectronic data sourcesEMR dataFuture studiesStatusParticipantsFactorsHIVSmokersSmokingStudy surveyCohort