Jasmine Saini, MBBS
Hospital ResidentCards
About
Research
Publications
2024
Steroid Profiling and Circadian Cortisol Secretion in Patients with Mild Autonomous Cortisol Secretion: A Cross-Sectional Study
Saini J, Singh S, Ebbehoj A, Zhang C, Nathani R, Fell V, Atkinson E, Achenbach S, Rivard A, Singh R, Grebe S, Bancos I. Steroid Profiling and Circadian Cortisol Secretion in Patients with Mild Autonomous Cortisol Secretion: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae468. PMID: 38981002, DOI: 10.1210/clinem/dgae468.Peer-Reviewed Original ResearchAutonomous cortisol secretionUrine steroid metabolomeSteroid metabolomeReference subjectsCortisol secretionSteroid profileSteroid productionUrine steroid profileSubgroup of patientsArea under the curveHigh-resolution mass spectrometry assayCross-sectional studyCircadian cortisol secretionMass spectrometry assayAndrogen ratioFree cortisolSerum measurementsCircadian secretionPatientsMetabolomicsSteroidsSeparate daysUrineSecretionGlucocorticoidHigh LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas
Sandooja R, Saini J, Kittithaworn A, Gregg-Garcia R, Dogra P, Atkinson E, Yu K, Fell V, Simha V, Connelly M, Dullaart R, Bancos I. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae392. PMID: 38870260, DOI: 10.1210/clinem/dgae392.Peer-Reviewed Original ResearchTriglyceride-rich lipoprotein particlesNonfunctioning adenomasCushing's syndromePatient categoriesLow density lipoprotein particlesSex-adjusted analysesHigh density lipoprotein particlesApoB concentrationsLipid lowering drug therapyCross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAdrenal cortical adenomaAutonomous cortisol secretionLipid lowering therapyLipoprotein particlesMultivariate logistic analysisIncreased cardiovascular riskLow density lipoprotein particle concentrationAge- and sex-adjusted analysesStudy of patientsCross sectional studyCortical adenomaCortisol excessLowering therapyEnhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Kittithaworn A, Dogra P, Saini J, Gruppen E, Atkinson E, Achenbach S, Yu K, Thangamuthu K, Connelly M, Dullaart R, Bancos I. Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae204. PMID: 38546526, DOI: 10.1210/clinem/dgae204.Peer-Reviewed Original ResearchMild autonomous cortisol secretionBranched-chain amino acidsMalignant adrenal massesNonfunctioning adenomasCushing's syndromeAdrenocortical carcinomaAdrenal massPrimary aldosteronismAdrenal disordersIncreasing TMAONon-functioning adrenal massesIncreased branched-chain amino acidsIncreased BCAACross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAutonomous cortisol secretionTrimethylamine N-oxideKetone bodiesAdrenal hormone excessSimilar to patientsMultivariate logistic analysisIncreased cardiovascular riskMetabolite trimethylamine N-oxideStudy of patients
2023
Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2023, dgad765. PMID: 38157409, DOI: 10.1210/clinem/dgad765.Peer-Reviewed Original ResearchMild autonomous cortisol secretionNonfunctioning adrenal adenomasFactors associated with chronic kidney diseaseChronic kidney diseaseTime of diagnosisAdrenal adenomaKidney functionSingle-center retrospective cohort studyMultivariate analysisSingle-center cohort study of patientsSingle-center cohort studyIncreased risk of chronic kidney diseaseCohort study of patientsRisk of chronic kidney diseaseAngiotensin II receptor blockersAutonomous cortisol secretionAngiotensin-converting enzyme inhibitorsTreated with adrenalectomyImpact of adrenalectomyIndependent risk factorRetrospective cohort studyII receptor blockersFollow-up periodStudy of patientsConverting enzyme inhibitorsGynecomastia in a Man With Adrenal Mass
Saini J, Navin P, Rivera M, Bancos I. Gynecomastia in a Man With Adrenal Mass. JCEM Case Reports 2023, 2: luad143. PMID: 38192879, PMCID: PMC10773200, DOI: 10.1210/jcemcr/luad143.Peer-Reviewed Original ResearchAdrenocortical carcinomaBilateral gynecomastiaEstrogen-secreting adrenal tumorRemoval of metastatic lesionsUltrasound-guided biopsyUrine steroid profileAdrenal malignancyDebulking surgeryLaparoscopic adrenalectomyAdrenal massAdrenal tumorsAdrenal insufficiencyMetastatic lesionsMultiple metastasesRare tumorInitial therapyMitotane therapyAdrenocortical adenomaEstrogen excessAndrogen precursorsEstrogen secretionGynecomastiaSurgical planningAndrogen metabolitesSteroid profileUse of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study
Saini J, Garcia R, Herndon J, Erickson D, Gruber L, Bancos I. Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study. Clinical Endocrinology 2023, 100: 203-211. PMID: 37997487, PMCID: PMC10872941, DOI: 10.1111/cen.14989.Peer-Reviewed Original ResearchConceptsDiagnosis of secondary adrenal insufficiencyOvernight metyrapone testSecondary adrenal insufficiencyCosyntropin stimulation testAdverse eventsAdrenal insufficiencyMetyrapone testPretest probabilityRetrospective study of adult patientsSingle-centre retrospective studyRetrospective single center studyDevelopment of adverse eventsStudy of adult patientsSingle center studyModerate pretest probabilityAdult patientsStimulation testCenter studyPatientsInsufficiencyDiagnosisCosyntropinTHU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Singh S, Fell V, Atkinson E, Achenbach S, Khosla S, Bancos I. THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.135. PMCID: PMC10554199, DOI: 10.1210/jendso/bvad114.135.Peer-Reviewed Original ResearchArea under the curveAutonomous cortisol secretionParathyroid hormoneBone metabolism biomarkersCortisol secretionFree cortisolType 1 collagenBone metabolismReference subjectsCircadian cortisol secretionCarboxy-terminal telopeptide of type 1 collagenMetabolic biomarkersMild autonomous cortisol secretionIncreased risk of fractureCross-sectional study of patientsCortisol productionParathyroid hormone productionDexamethasone suppression testRisk of fractureCarboxy-terminal telopeptideImpaired bone metabolismStudy of patientsCircadian secretory patternClinical research unitIncreased cortisol productionTHU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Saini J, Nathani R, Singh S, Thangamuthu K, Suresh M, Zhang C, Ebbehøj A, Thomas M, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. THU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study. Journal Of The Endocrine Society 2023, 7: bvad114.136. PMCID: PMC10553766, DOI: 10.1210/jendso/bvad114.136.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testPost-DST cortisolFluid cognitionCrystallized cognitionCognitive performanceCognitive impairmentNIH Toolbox Cognition BatteryPattern of cognitive impairmentCrystallized composite scoresComposite scoreReference subjectsT-scoreCognitive batterySubgroup analysisCognitive agingComposite cognitionMild autonomous cortisol secretionCognitive domainsNIH ToolboxSubgroup analysis of patientsImpaired cognitionCognitive functionSingle-center cross-sectional studyCompared to reference subjectsTHU603 Bone Fragility In Mild Autonomous Cortisol Secretion: A Cross-Sectional Cohort Study
Zhang C, Singh S, Saini J, Suresh M, Thangamuthu K, Nathani R, Ebbehøj A, Fell V, Achenbach S, Atkinson E, Khosla S, Bancos I. THU603 Bone Fragility In Mild Autonomous Cortisol Secretion: A Cross-Sectional Cohort Study. Journal Of The Endocrine Society 2023, 7: bvad114.133. PMCID: PMC10554138, DOI: 10.1210/jendso/bvad114.133.Peer-Reviewed Original ResearchTrabecular bone scoreBone mineral densityDual-energy X-ray absorptiometryAutonomous cortisol secretionBone turnover markersAdrenal nodulesReference subjectsTurnover markersHR-pQCTBone massBone metabolismDecreased TBSTrabecular volumetric bone mineral densityCross-sectional single-center studyMedian age of study participantsOvernight dexamethasone suppression testCortisol secretionVolumetric bone mineral densityAnalysis of bone turnover markersNon-dominant radiusHigh-resolution peripheral quantitative computed tomographyCross-sectional cohort studySingle-center studyAge of study participantsIncreased fracture riskFRI185 Post-adrenalectomy Improvement Of Kidney Function In Patients With Mild Autonomous Cortisol Secretion And Nonfunctioning Adrenal Adenoma
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. FRI185 Post-adrenalectomy Improvement Of Kidney Function In Patients With Mild Autonomous Cortisol Secretion And Nonfunctioning Adrenal Adenoma. Journal Of The Endocrine Society 2023, 7: bvad114.180. PMCID: PMC10553513, DOI: 10.1210/jendso/bvad114.180.Peer-Reviewed Original ResearchNonfunctioning adrenal adenomasImprovement of eGFRAutonomous cortisol secretionImprovement of kidney functionPost-adrenalectomyChronic kidney diseaseKidney functionAdrenal adenomaMild autonomous cortisol secretionMultivariate analysisRetrospective single-center studyCortisol secretionPrevalence of chronic kidney diseaseDecline of eGFRYounger ageSingle-center studyEffects of hypercortisolismPrevalence of hypertensionFactors associated andPrevalence of diabetesProportion of womenDelta eGFRAntihypertensive therapyAssociated with improvementsAdult patients