Hongli Wang
Research
Publications
2025
Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making
Wang H, Ortega H, Kelly E, Indajang J, Savalia N, Glaeser-Khan S, Feng J, Li Y, Kaye A, Kwan A. Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making. Science Advances 2025, 11: eadr9916. PMID: 40138407, PMCID: PMC11939063, DOI: 10.1126/sciadv.adr9916.Peer-Reviewed Original ResearchConceptsNeuromodulatory signalsCompetitive decision-makingCholinergic transientsNE signalingPremotor cortexAnimal's propensityBehavioral correlatesAcetylcholine signalingMatching pennies gamePattern of NEBehavioral eventsNorepinephrineCortexDecision-makingAcetylcholinePremotorFunctional relevanceOptogenetics
2022
Pupil Correlates of Decision Variables in Mice Playing a Competitive Mixed-Strategy Game
Wang H, Ortega HK, Atilgan H, Murphy CE, Kwan AC. Pupil Correlates of Decision Variables in Mice Playing a Competitive Mixed-Strategy Game. ENeuro 2022, 9: eneuro.0457-21.2022. PMID: 35168951, PMCID: PMC8925722, DOI: 10.1523/eneuro.0457-21.2022.Peer-Reviewed Original Research
2019
Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse
Siniscalchi MJ, Wang H, Kwan AC. Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse. Cerebral Cortex 2019, 29: 4090-4106. PMID: 30615132, PMCID: PMC6735259, DOI: 10.1093/cercor/bhy292.Peer-Reviewed Original ResearchConceptsMedial frontal cortexInstrumental behaviorFrontal cortexAuditory discrimination taskSecondary motor regionsSelection of actionsNeural representationDiscrimination taskNeural ensemble activityReward magnitudeChoice signalsReward amountUnrewarded choicesPast choicesMotor regionsLayer 2/3Rodent brainProbabilistic outcomesCategorical presenceBehavioral effectsPopulation codingEnsemble activityOutcomesCortexConsistent influence