2024
W74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS
Xia C, Alliey-Rodriguez N, Tamminga C, Keshavan M, Pearlson G, Keedy S, Parker D, Bishop J, Chen C, Liu C, Gershon E. W74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS. European Neuropsychopharmacology 2024, 87: 141-142. DOI: 10.1016/j.euroneuro.2024.08.283.Peer-Reviewed Original ResearchTranscriptome-wide association studyGenome-wide complex trait analysisPotential causal genesQuantitative Trait LociRisk genesEvent-related potentialsPolygenic risk scoresIntermediate phenotypesGene OntologyCase-control statusPsychotic disordersComplex trait analysisGenotype principal componentsIdentified risk genesGenetic correlationsMulti-omics analysisMendelian randomizationPRS-CSxPsychosis risk genesCausal genesAssociation studiesGenomic characteristicsDetect significant associationsGene associationsBipolar-Schizophrenia Network
2023
Evaluation of boundaries between mood and psychosis disorder using dynamic functional network connectivity (dFNC) via deep learning classification
Rokham H, Falakshahi H, Fu Z, Pearlson G, Calhoun V. Evaluation of boundaries between mood and psychosis disorder using dynamic functional network connectivity (dFNC) via deep learning classification. Human Brain Mapping 2023, 44: 3180-3195. PMID: 36919656, PMCID: PMC10171526, DOI: 10.1002/hbm.26273.Peer-Reviewed Original ResearchConceptsDynamic functional network connectivityFunctional network connectivityDSM-IVFMRI-based measuresResting-state fMRI dataBiomarker-based approachPsychosis disordersClinical courseBipolar-Schizophrenia NetworkClinical evaluationSymptomatic measuresHealthy controlsPsychotic illnessHealthy individualsNeurological observationsMental disordersReliability of diagnosisStatistical group differencesMental healthNeuroimaging techniquesStatistical ManualDiagnostic problemsGroup differencesIntermediate phenotypesDisorders
2021
Longitudinal Stability of Psychosis Biomarkers: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP)
Trotti R, Parker D, McDowell J, Pearlson G, Keshavan M, Keedy S, Gershon E, Hill S, Ivleva E, Tamminga C, Clementz B. Longitudinal Stability of Psychosis Biomarkers: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP). Biological Psychiatry 2021, 89: s124. DOI: 10.1016/j.biopsych.2021.02.321.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkIntermediate phenotypes
2020
Neuroanatomical Sex Differences in the Visual Cortex of Individuals With Psychosis: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes
Turkozer H, Lizano P, Adhan I, Ivleva E, Lutz O, Zeng A, Raymond N, Clementz B, Pearlson G, Sweeney J, Gershon E, Keshavan M, Tamminga C. Neuroanatomical Sex Differences in the Visual Cortex of Individuals With Psychosis: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes. Biological Psychiatry 2020, 87: s205. DOI: 10.1016/j.biopsych.2020.02.533.Peer-Reviewed Original ResearchLongitudinal Stability of EEG Psychosis Biomarkers: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP)
Trotti R, Parker D, Tamminga C, Pearlson G, Keshavan M, Keedy S, Gershon E, McDowell J, Clementz B. Longitudinal Stability of EEG Psychosis Biomarkers: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP). Biological Psychiatry 2020, 87: s409-s410. DOI: 10.1016/j.biopsych.2020.02.1045.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkIntermediate phenotypes
2019
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
Thomas O, Parker D, Trotti R, McDowell J, Gershon E, Sweeney J, Keshavan M, Keedy S, Ivleva E, Tamminga C, Pearlson G, Clementz B. Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Biomarkers In Neuropsychiatry 2019, 1: 100002. PMID: 36643612, PMCID: PMC9837786, DOI: 10.1016/j.bionps.2019.100002.Peer-Reviewed Original ResearchPsychosis biotypesHealthy personsBipolar-Schizophrenia NetworkSingle-trial powerFirst-degree biological relativesNeural activity differencesInter-stimulus intervalBiotype 2Intermediate Phenotypes (B-SNIP) consortiumPsychosis casesEffective treatmentIntrinsic activityPsychosis subgroupsNeural modulationLow intrinsic activityDSM groupNeural activitySocial functioningBiotype characterizationBiological relativesConventional diagnosisIntermediate phenotypesDifferentiating featuresDSM syndromesProbands
2017
10. Brain Structure Biomarkers at the Psychosis/Nonpsychosis Interphase: Findings From the Bipolar–Schizophrenia Network for Intermediate Phenotypes
Ivleva E, Clementz B, Dutcher A, Aslan S, Witte B, Poudyal G, Lu H, Meda S, Pearlson G, Sweeney J, Keshavan M, Tamminga C. 10. Brain Structure Biomarkers at the Psychosis/Nonpsychosis Interphase: Findings From the Bipolar–Schizophrenia Network for Intermediate Phenotypes. Schizophrenia Bulletin 2017, 43: s10-s10. PMCID: PMC5475460, DOI: 10.1093/schbul/sbx021.029.Peer-Reviewed Original Research