Research & Publications
I am very pleased to be part of the Yale Fertility Center. I look forward to providing the best clinical experience for each of my patients while utilizing one of the most advanced reproductive facilities in the U.S. My approach is to provide the most compassionate and contemporary infertility services available to meet the individual needs and personal values of my patients. Areas of special clinical interest include optimizing age-related infertility, pre-implantation genetic diagnosis, male factor infertility, recurrent pregnancy loss, polycystic ovarian syndrome and fertility preservation.
My research includes the mechanisms of reproductive aging. This work has led to a simple blood test, antimullerian hormone (AMH), used worldwide today that helps determine the health of a woman’s ovaries, a rough estimate of her egg count and real time assessment of her biological clock. To learn more read: https://www.yalemedicine.org/stories/fertility-test/. or https://medicine.yale.edu/news/yale-medicine-magazine/overcoming-infertility/ or https://medicine.yale.edu/news/yale-medicine-magazine/a-grand-challenge-slowing-the-biological-clock/.
I am currently co-editing two books entitled "Optimizing the Management of Fertility in Women Over 40" to be published by Cambridge University Press scheduled for publication in 2021 and "Polycystic Ovary Syndrome - Current & Emerging Concepts: An Individualized Approach to Management" to be published by Springer in 2022.
Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reprod Biol Endocrinol. 2020 Nov 19;18(1):113.
The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reprod Biol Endocrinol. 2020 Nov 21;18(1):118.
Kotlyar A, Seifer DB. Anti-Mullerian hormone as a qualitative marker- or just quantity? Curr Opin Obstet Gynecol 32:219-226, 2020.
Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a gap year after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertil Steril 111:1109-1110, 2019.
Tal R, Seifer DB, Wantman E, Baker VL, Tal O. AMH as predictor of live birth following assisted reproductive technology: analysis of 85,062 fresh and thawed cycles from the SART COR database for 2012-2013. Fertil Steril. 109:258-265, 2018.
Kushnir VA, Seifer DB, Barad DH, Sen A, Gleicher N. Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine. J Assist Reprod Genet. 2017 Sep;34(9):1105-1113.
Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of ART outcomes of cycles with ultra-low serum antimüllerian hormone (AMH): a multivariate analysis of over 5000 autologous cycles from the SART CORS database for 2012-2013. Fertil Steril 105:385-93, 2016.
Seifer DB, Tal R (ed): Anti-Mullerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. New York, Nova Science, 2016.
I also have had a research focus in population-based health outcomes research to gain better understanding of the trends of reproductive aging, health care disparities in IVF, vitamin D deficiency in reproductive health and a global improvement in the clinical practice of reproductive medicine. This has been achieved through collaborative studies and analysis of large clinical data sets from well characterized populations through the Assisted Reproductive Technologies Clinical Outcomes Reporting System (SART CORS), the Women's Interagency HIV Study (WIHS), the National Assisted Reproductive Technology Surveillance System (NASS) registries and the Reproductive Medicine Network (RMN).
Zagadailov P, Seifer DB, Shan H, Zarek SM, Hsu AL. Do state insurance mandates alter ICSI utilization? Reprod Biol Endocrinol. 2020 Apr 25;18(1):33. (NASS database)
Butts SF*, Seifer DB*, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Kraetz SA, Santoro N, Zhang H, Diamond MP, Legro RS. Vitamin D deficiency is associated with poor ovarian stimulation outcome in PCOS but not unexplained infertility. J Clin Endocrinol Metab, Metab, 2019 Feb 1;104(2):369-378. (RMN database) *co-first authors
Luke B, Brown MB, Wantman E, Seifer DB, Sparks AT, Lin PC, Doody KJ, Van Voorhis BJ, Spector LG. Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality.J Assist Reprod Genet. 2019 Jan;36(1):121-138. doi: 10.1007/s10815-018-1333-z. (SART CORS database linked with birth and death certificate database in 14 Departments of Health)
Luke B, Brown MB, Wantman E, Doody K, Seifer DB, Spector LG. Risk of severe maternal morbidity maternal age, fertility status, plurality and mode of delivery: A US study in eight states. Am J Obstet Gynecol. 2018 Oct 12. pii: S0002-9378(18)30894-9. doi: 10.1016/j.ajog.2018.10.012. (SART CORS database linked with birth certificate database in 8 Departments of Health)
Zagadailov P, Hsu A, Stern JE, Seifer DB. Temporal differences in utilization of intracytoplasmic sperm injection among U.S. regions. Obstet Gynecol. 2018 Aug;132(2):310-320. (NASS database)
Xu J, Lawson MS, Xu F, Du Y, Tkachenko OY, Bishop CV, Pejovic-Nezhat L, Seifer DB, Hennebold JD. Expression of vitamin D biosynthesis and signaling system in the rhesus macaque ovary: a role for regulating follicular development. Front Physiol 14;9:1600, 2018.
I am a past-president of the Society for Assisted Reproductive Technology (SART), the primary, national organization that sets clinical and laboratory guidelines as well as the standards for safety and quality metrics for the practice of IVF in the US. As such, I am interested in using patient-physician advocacy to move toward expanding insurance coverage for infertility treatment for those who are without such benefits as well as moving toward strategies of closing the gap in disparities of access and outcomes in the utilization of IVF. I am also actively encouraging and mentoring young Yale faculty to bring their energy and insight to a national level within SART.
Seifer DB, Wantman E, Sparks AE, Luke B, Doody KJ, Toner JP, van Voorhis BJ, Lin PC, Reindollar RH. National survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies. Fertil Steril. 2018 Nov;110(6):1081-1088.
As Co-Editor-in- Chief of Reproductive Biology and Endocrinology (RB&E) https://rbej.biomedcentral.com/ I am actively involved in encouraging the publication of quality and novel research in the reproductive sciences.
Complete list of Published Work: https://www.ncbi.nlm.nih.gov/sites/myncbi/1B9unppU5pqg0L/bibliography/55102886/public/?sort=date&direction=descending
Education & Training
- Board CertificationAB of Obstetrics & Gynecology, Reproductive Endocrinology & Infertility (1994, recertified: 2020)
- Board CertificationAB of Obstetrics & Gynecology, Obstetrics & Gynecology (1989, recertified: 2020)
Honors & Recognition
|Prize Paper Awards for SART and ASRM - Co-author||ASRM||2020|
|Prize Paper Award for Health Care Disparities- Co-author||ASRM||2019|
|ASRM Star Award||American Society of Reproductive Medicine||2016, 2017, 2018, 2019, 2020|
|America’s Top Doctors Castle Connolly Medical Guide for 12 years||Castle Connolly||2014|
|Thomas Alva Edison Patent Award||Research and Development Council of New Jersey||2011|
|Inventor of the Year Award||New Jersey Inventors Hall of Fame||2011|
|Life Teacher Award||Maimonides Medical Center||2007|
|Society for Assisted Reproductive Technology (SART)||President of SART 2017-2018; Member of Presidential and Executive Council of Society for Assisted Reproductive Technology (SART) 2016 - 2021.||2017 - 2021|
|Reproductive Biology and Endocrinology||Co-Editor-in-Chief||2016 - Present|
|NICHD – NIH Reproduction, Andrology, Gynecology Study Section||2004 - 2008|
|FDA Advisory Committee Obstetrics and Gynecology Devices Panel||2001 - 2005|