2024
Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis
Hussain N, Ma C, Hirschfield G, Walmsley M, Hanford P, Vesterhus M, Kowdley K, Bergquist A, Ponsioen C, Levy C, Assis D, Schramm C, Bowlus C, Trauner M, Aiyegbusi O, Jairath V, Trivedi P. Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. BMJ Open 2024, 14: e080143. PMID: 38926149, PMCID: PMC11216047, DOI: 10.1136/bmjopen-2023-080143.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisClinical trialsSclerosing cholangitisCore outcome setImmune-mediated liver diseasesPrimary sclerosing cholangitis treatmentOutcome measuresEvaluate novel therapiesSlow disease progressionPatient-reported outcome measuresMedical therapyNovel therapiesLiver fibrosisDisease progressionHistological assessmentLiver diseaseInternational two-round Delphi surveyImaging-based biomarkersIntervention trialsTherapyConsensus meetingHealthcare payersCholangitisSemistructured qualitative interviewsTwo-round Delphi survey
2023
Recent Advances in the Management of Primary Sclerosing Cholangitis
Assis D, Bowlus C. Recent Advances in the Management of Primary Sclerosing Cholangitis. Clinical Gastroenterology And Hepatology 2023, 21: 2065-2075. PMID: 37084929, DOI: 10.1016/j.cgh.2023.04.004.Peer-Reviewed Original ResearchConceptsChronic cholestatic liver diseasePrimary sclerosing cholangitisInflammatory bowel diseasePrognostication of patientsCholestatic liver diseaseSclerosing cholangitisBowel diseaseLiver failureClinical featuresLiver diseaseMedical managementBiliary treeComplex pathophysiologyEffective therapyPharmacologic agentsRare natureCurrent conceptsDiseaseCholangitisFurther studiesCholangiocarcinomaPatientsPathophysiologyTherapyPrognosticationOutcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease
Sayed A, Assis D, Silveira M, Deng Y, Ciarleglio M, Gaidos J, Proctor D, Al-Bawardy B. Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease. European Journal Of Gastroenterology & Hepatology 2023, 35: 270-274. PMID: 36708297, DOI: 10.1097/meg.0000000000002510.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisInflammatory bowel diseasePSC-IBDEndoscopic healingTherapy groupAdvanced therapiesClinical remissionBowel diseaseAcute ascending cholangitisRate of cholangitisSmall bowel involvementThird of patientsAscending cholangitisSclerosing cholangitisAdult patientsBowel involvementSecondary outcomesMedian agePrimary outcomeRetrospective studyHigh riskCholangitisPatientsTherapyLarger study
2018
Chronic Complications of Cholestasis Evaluation and Management
Assis DN. Chronic Complications of Cholestasis Evaluation and Management. Clinics In Liver Disease 2018, 22: 533-544. PMID: 30259851, DOI: 10.1016/j.cld.2018.03.014.BooksMeSH KeywordsAbsorptiometry, PhotonAvitaminosisBone Density Conservation AgentsBone Diseases, MetabolicCarcinoma, HepatocellularCholestasisDiet, HealthyEarly Detection of CancerEsophageal and Gastric VaricesExerciseFibric AcidsGastrointestinal HemorrhageHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasHypertension, PortalLiver Cirrhosis, BiliaryLiver NeoplasmsMass ScreeningOsteoporosisOsteoporotic FracturesVitamin A DeficiencyVitamin D DeficiencyVitamin E DeficiencyVitamin K DeficiencyConceptsPrimary biliary cholangitisChronic cholestasisFat-soluble vitamin deficiencyEarly-stage diseaseMetabolic bone diseaseCardiovascular eventsChronic complicationsPortal hypertensionBiliary cholangitisVitamin deficiencyBone diseaseLong-term effectsNotable riskCholestasisComplicationsPatientsPractical managementDiseaseRiskHarmful consequencesCholangitisHypertensionHyperlipidemiaOsteoporosisTherapy
2015
Gastrointestinal Disorders in Cystic Fibrosis
Assis DN, Freedman SD. Gastrointestinal Disorders in Cystic Fibrosis. Clinics In Chest Medicine 2015, 37: 109-118. PMID: 26857772, DOI: 10.1016/j.ccm.2015.11.004.BooksConceptsCystic fibrosisDistal intestinal obstruction syndromeCommon GI complicationsIntestinal obstruction syndromeCare of patientsGI complicationsGastrointestinal manifestationsObstruction syndromeGI disordersGI malignanciesIntestinal overgrowthPulmonary functionClinical presentationGastrointestinal disordersPancreatic insufficiencyInnovative therapiesRecent approvalModulating agentsFibrosisDisordersComplicationsPatientsMalignancySyndromeTherapy