2019
Single-cell connectomic analysis of adult mammalian lungs
Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Science Advances 2019, 5: eaaw3851. PMID: 31840053, PMCID: PMC6892628, DOI: 10.1126/sciadv.aaw3851.Peer-Reviewed Original ResearchConceptsTissue homeostasisMammalian lungSingle-cell RNA sequencing techniquesAdult mammalian lungRNA sequencing techniquesCell-cell interactionsSequencing techniquesKey pathwaysAlveolar type IFunctional roleCell typesCell populationsRegenerative medicineHomeostatic mechanismsHomeostasisFine architectureFunctional lung tissueIncomplete understandingMajor roleType ITissueRegulationPathwayAlveolar cell populationsDistal lung
2016
Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms
Wörmann ME, Horien CL, Johnson E, Liu G, Aho E, Tang CM, Exley RM. Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms. Microbiology 2016, 162: 487-502. PMID: 26813911, PMCID: PMC4891991, DOI: 10.1099/mic.0.000248.Peer-Reviewed Original ResearchConceptsHuman epithelial cellsN. cinereaFunction of piliEpithelial cellsType IV piliPathogen Neisseria meningitidisHost-pathogen interactionsClose taxonomic relationshipFormation of microcoloniesPilus-pilus interactionsGenome analysisTaxonomic relationshipsMajor pilinTfp expressionPilin expressionSpecies sharesPilin genePathogenic NeisseriaNon-pathogenic Neisseria speciesCell surfaceNeisseria cinereaCinereaRole of TFPGenesNon-pathogenic Neisseria