2015
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome
Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 893-898. PMID: 25561540, PMCID: PMC4311862, DOI: 10.1073/pnas.1419533112.Peer-Reviewed Original ResearchConceptsTourette syndromeCholinergic interneuronsDorsolateral striatumSensorimotor gatingD-amphetamine challengeLarge cholinergic interneuronsSpecific cell ablationInterneuron deficitsStriatal interneuronsAcute administrationGABAergic markersDopaminergic drugsAvailable treatmentsPostmortem studiesPrepulse inhibitionTic disordersSevere diseaseHuman putamenMotor coordinationInterneuronsTargeted ablationSevere endStriatumAcute stressGilles de
2013
Tourette Syndrome and Tic Disorders
Williams K, Bloch M, State M, Pittenger C. Tourette Syndrome and Tic Disorders. 2013, 1048-1060. DOI: 10.1093/med/9780199934959.003.0079.Peer-Reviewed Original ResearchTourette syndromeTic disordersCortico-basal ganglia circuitryImmune-brain interactionPost-mortem findingsSubset of casesFunctional imaging studiesAttention deficit disorderObsessive-compulsive disorderVocal ticsDisorder pathophysiologySevere endImaging studiesDeficit disorderSpecific populationsDisordersSyndromeSensory phenomenaRecent findingsHeterogeneous genetic architecturePathophysiologyInterneuronsEtiologyAbnormalitiesFindings