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Caren Carpenter, PhD

Professor Emeritus of Orthopaedics and Rehabilitation

About

Titles

Professor Emeritus of Orthopaedics and Rehabilitation

Appointments

Departments & Organizations

Education & Training

PhD
Boston University (1976)

Research

Overview

We are currently actively involved in characterizing the circulating forms of osteocalcin and defining the factors that influence its synthesis and secretion. To that end, we have developed site specific antibodies and are investigating the circulating forms of osteocalcin through the use of these monoclonal antibodies. We are (1) investigating the source and regulation of osteocalcin production, and (2) identifying regulators of osteocalcin synthesis and secretion in vivo and in vitro.

There is also considerable evidence that vitamin K deficiency has a negative impact on bone. To that end we are investigating the relationships between vitamin K status, calcium homeostasis and biosynthesis of functional osteocalcin.

Current in vivo studies include analysis of the phenotype of several transgenic mice with targeted deletions of bone matrix proteins. Single and double knock-out mice are being developed in order to determine the role of these proteins in skeletal modeling and remodeling.

Medical Subject Headings (MeSH)

Bone Diseases; Bone Matrix; Immunoassay; Orthopedics; Osteocalcin; Vitamin K

Publications

2008

2004

2003

Get In Touch

Contacts

Academic Office Number
Mailing Address

Orthopaedics & Rehabilitation

P.O. Box 208071

New Haven, CT 06520-8071

United States