Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsArgyrios Tzouvelekis, MD, PhD
Associate Professor Adjunct of Medicine (Pulmonary, Critical Care and Sleep Medicine)About
Research
Publications
2026
Pulmonary Fibrosis Beyond the Lung: Adipose Tissue as a Systemic Modifier of Fibrotic Remodeling
Tsiri P, Crestani B, Mailleux A, Tzouvelekis A. Pulmonary Fibrosis Beyond the Lung: Adipose Tissue as a Systemic Modifier of Fibrotic Remodeling. Diagnostics 2026, 16: 1493. PMID: 42196858, PMCID: PMC13205186, DOI: 10.3390/diagnostics16101493.Peer-Reviewed Original ResearchFibrotic remodelingFibrotic ILDPulmonary fibrosisClinical managementAdipose dysfunctionAdipose tissueMetabolic reprogramming strategiesPrimary initiatorPerivascular inflammationInterstitial abnormalitiesVisceral adiposityClinical dataPatient stratificationExtracellular matrix depositionInflammatory contextIL-6Metabolic phenotypeMetabolic reprogrammingReprogramming strategiesBody compositionTherapeutic implicationsImaging studiesMyofibroblast activationAdipokine imbalanceBiomarker developmentDesign of the MERCURION-IPF trial – intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis
Sotiropoulou V, Sampsonas F, Vasarmidi E, Antoniou K, Gogali A, Kostikas K, Drakopanagiotakis F, Steiropoulos P, Margaritopoulos G, Porpodis K, Daniil Z, Tomos I, Papanikolaou I, Tzilas V, Loukides S, Tzouvelekis A. Design of the MERCURION-IPF trial – intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis. Frontiers In Immunology 2026, 17: 1777564. PMID: 42164489, PMCID: PMC13183516, DOI: 10.3389/fimmu.2026.1777564.Peer-Reviewed Original ResearchConceptsAcute exacerbation of idiopathic pulmonary fibrosisExacerbation of idiopathic pulmonary fibrosisAE-IPFIdiopathic pulmonary fibrosisIntravenous immunoglobulinAcute exacerbationPulmonary fibrosisTreatment of acute exacerbations of idiopathic pulmonary fibrosisEfficacy of intravenous immunoglobulin (IVIGTreatment strategiesIntravenous immunoglobulin (IVIGAmerican Thoracic Society definitionPhase III clinical trialsImmunoglobulin (IVIGStandard treatment strategyIII clinical trialsBroad-spectrum antibioticsCurrent treatment strategiesIn-Hospital MortalityPulse corticosteroidsCardiac decompensationPrimary endpointProphylactic anticoagulationPulmonary embolismSecondary endpointsA39-20 SURPASS-IPF: Study Design of a Phase 3, Head-to-head Trial of Deupirfenidone Compared to Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
Maher T, Bergna M, Case A, Choi W, Cottin V, Golod D, Graham C, Kulkarni T, Nathan S, Shore J, Song J, Tomos I, Tzouvelekis A, Wijsenbeek M. A39-20 SURPASS-IPF: Study Design of a Phase 3, Head-to-head Trial of Deupirfenidone Compared to Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2244. DOI: 10.1093/ajrccm/aamag162.2244.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisHead-to-head trialsPulmonary fibrosisCentral reviewPrimary endpointAcute exacerbationAcute exacerbation of idiopathic pulmonary fibrosisExacerbation of idiopathic pulmonary fibrosisDiagnosis of idiopathic pulmonary fibrosisProgressive loss of lung functionHigh-resolution chest CTOpen-label extension studyBlinded study drugSuperior to placeboActive comparator trialsPhase 2b trialPhase 3 studyBaseline to weekLoss of lung functionProgressive lossPrimary outcome measureDose modificationOverall survivalChest CTDouble-blindPleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3).
Chu J, Hollins S, Elsheikh A, Gerry S, Manoharan N, Zarganes-Tzitzikas T, Feng Y, Antoun E, Bedawi E, Corcoran J, Gilmour A, Mei F, Monaco F, Tomasetti M, Tzouvelekis A, Koulousousa E, Sampsonas F, Bhatnagar M, Chen E, Brennan P, Dong T, Pavord I, Song Y, Chalmers J, Knight J, Rahman N, Kanellakis N. Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3). European Respiratory Journal 2026, 2600113. PMID: 42025308, DOI: 10.1183/13993003.00113-2026.Peer-Reviewed Original ResearchNeutrophil extracellular trapsOne-year mortalityAssociation of neutrophil extracellular trapsOne-year survivalRisk of one-year mortalitySonographic septationPleural infectionDisease severityExtracellular trapsHigher risk of one-year mortalityHigh riskBiomarkers of disease severityPilot cohortAssociated with disease severityRescue treatmentValidation cohortDiscovery cohortIndependent cohortHigher oddsEnzyme therapyScore groupRAPID scoreCohortCitrullinated fibrinMulticohort studyDeupirfenidone Compared with Pirfenidone and Placebo in Idiopathic Pulmonary Fibrosis (ELEVATE-IPF): a Phase 2b Randomized Placebo-Controlled Trial
Maher T, Hamblin M, Choi W, Case A, Tomos I, Tzouvelekis A, Shore J, Bergna M, Golod D, Elenko E, Zhang Y, Graham C, Song J, Kulkarni T, Investigators T. Deupirfenidone Compared with Pirfenidone and Placebo in Idiopathic Pulmonary Fibrosis (ELEVATE-IPF): a Phase 2b Randomized Placebo-Controlled Trial. American Journal Of Respiratory And Critical Care Medicine 2026, aamag155. PMID: 42085224, DOI: 10.1093/ajrccm/aamag155.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisForced Vital CapacityPulmonary fibrosisRandomized placebo-controlled trialPlacebo-controlled trialLung disease progressionActive treatment armsPosterior mean differencePlacebo armPrimary endpointFavorable tolerabilityAdverse eventsTreatment armsPlaceboPharmacodynamic activityPirfenidoneDisease progressionPharmacokinetic profileMean changePatientsMean differenceVital capacitySecondary analysisFibrosisEfficacy356P Implementing low-dose CT lung cancer screening in Greece: Results from a nationwide multicentre pilot programme
Lampaki S, Gourgoulianis K, Tzouvelekis A, Steiropoulos P, Karetsi E, Sampsonas F, Chadia K, Kamaterou M, Moulagiannis M, Chatziandreou E, Patel-Bell K, Manika K, Spyratos D. 356P Implementing low-dose CT lung cancer screening in Greece: Results from a nationwide multicentre pilot programme. ESMO Open 2026, 11: 106669. DOI: 10.1016/j.esmoop.2026.106669.Peer-Reviewed Original ResearchWhen cancer treatment affects the lungs: a clinical overview on pulmonary toxicity induced by new cancer drugs
Komninos D, Psarros E, Theochari E, Tsirikos G, Sampsonas F, Tzouvelekis A. When cancer treatment affects the lungs: a clinical overview on pulmonary toxicity induced by new cancer drugs. Expert Review Of Respiratory Medicine 2026, ahead-of-print: 1-14. PMID: 41717783, DOI: 10.1080/17476348.2026.2631816.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImmune checkpoint inhibitorsCheckpoint inhibitorsPulmonary toxicityAdverse eventsLung cancerTherapeutic landscape of lung cancerHigh indexHigh index of suspicionTherapeutic landscapePulmonary adverse eventsSpectrum of adverse eventsTyrosine kinase inhibitorsIndex of suspicionClinical trial dataClinically significant concernsComprehensive literature searchPulmonary complicationsPulmonary eventsSurvival outcomesTargeted therapySpecialized centersKinase inhibitorsCancer therapyTreatment continuationPneumonitisThe Fibrotic–Cancer Continuum in IPF: Shared Mechanisms, Clinical Implications and Therapeutic Challenges
Tsiri P, Kouvela M, Papaioannou O, Sotiropoulou V, Katsaras M, Syrigos N, Sampsonas F, Tzouvelekis A. The Fibrotic–Cancer Continuum in IPF: Shared Mechanisms, Clinical Implications and Therapeutic Challenges. Life 2026, 16: 295. PMID: 41752931, PMCID: PMC12941835, DOI: 10.3390/life16020295.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPatient survivalPulmonary fibrosisLung cancerIdiopathic pulmonary fibrosisLethal lung diseaseMolecular pathogenetic mechanismsAnti-fibrotic agentsLung cancer developmentPotential risk factorsAnti-cancer drugsLung tumorsTherapeutic algorithmTherapeutic challengeIPF treatmentLung scarringLung diseasePathogenetic mechanismsDisease entityMesenchymal phenotypeEarly diagnosisCancer developmentTherapeutic approachesRisk factorsQuality of lifeLungLipidemic Profile of Patients with Non-Small Cell Lung Cancer and Its Association with Driver Mutations: A Tertiary Center Retrospective Study
Lagadinou M, Efthymiou D, Sampsonas F, Karidis P, Marlafeka I, Adamopoulou E, Michailides C, Bosgana P, Papaioannou O, Psarros E, Tsiri P, Sotiropoulou V, Katsaras M, Tzelepi V, Tzouvelekis A, Marangos M. Lipidemic Profile of Patients with Non-Small Cell Lung Cancer and Its Association with Driver Mutations: A Tertiary Center Retrospective Study. Cancers 2026, 18: 374. PMID: 41681847, PMCID: PMC12896490, DOI: 10.3390/cancers18030374.Peer-Reviewed Original ResearchNon-small cell lung cancerNon-small cell lung cancer patientsSquamous cell carcinomaCell lung cancerCell carcinomaHDL levelsLipidemic profileLung cancerDriver mutationsSquamous cell carcinoma patientsCell carcinoma patientsReal-world cohortBenjamini-Hochberg false discovery rateLow-density lipoprotein (LDL)Associated with driver mutationsProfile of patientsSerum lipid parametersStatistically significant differenceCarcinoma patientsHistological subtypesPrognostic roleRetrospective studyNon-smallPredominant subtypeLipid parameters
2025
Diagnosis and treatment of sarcoidosis with nephrocalcinosis: A case report
Tryfona F, Psarros E, Komninos D, Tzelepi V, Sampsonas F, Tzouvelekis A. Diagnosis and treatment of sarcoidosis with nephrocalcinosis: A case report. Pneumon 2025, 38: 1-4. DOI: 10.18332/pne/216113.Peer-Reviewed Original Research