Argyrios Tzouvelekis, MD, PhD
Associate Professor Adjunct of Medicine (Pulmonary, Critical Care and Sleep Medicine)Cards
About
Titles
Associate Professor Adjunct of Medicine (Pulmonary, Critical Care and Sleep Medicine)
Biography
Dr. Argyrios Tzouvelekis’s research focus is the mechanisms of pulmonary fibrosis, centering on the identification of prognostic biomarkers and the delineation of novel therapeutic targets, using advanced methodological tools, including microarray and miRNA platforms, nCounter (Nanostring) technology and animal models of lung fibrosis (ie bleomycin-induced). Dr. Tzouvelekis’s specialties are focused on the implementation of pioneering research technologies, such as microarrays, as well as the application of novel therapeutic interventions including stem cells. His main areas of expertise are Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases. He currently enumerates 72 publications (67 in PubMed) in peer-reviewed scientific journals (with an overall of 1018 citations and a total H-index=19), more than 60 presentations and lectures in national and international conferences and 20 grants and honors, including European Respiratory Society a) Long Term Fellowship and b) Young Scientist Sponsorship and c) American Lung Association Senior Research Training Fellowship, d) an ERS/Marie Skłodowska-Curie Postdoctoral Research Fellowship.Dr Tzouvelekis is also the inventor of a therapeutic patent entitled “Inhaled or aerosolized delivery of thyroid hormone to the lung as a novel therapeutic agent in fibrotic lung diseases” OCR#6368 (the “Invention”), disclosed to Yale University. His research interests mainly focus on understanding the role of phosphatases and thyroid hormone signaling in the pathogenesis of lung fibrosis. He was trained in major aspects of translational medicine, including genomics and proteomics, as well as in molecular and cellular fibroblast biology.
Appointments
Pulmonary, Critical Care & Sleep Medicine
Associate Professor AdjunctPrimary
Other Departments & Organizations
- Internal Medicine
- Kaminski Lab
- Pulmonary, Critical Care & Sleep Medicine
Education & Training
- MS
- DEMOCRITUS UNIVERSITY OF THRACE (2011)
- PhD
- DEMOCRITUS UNIVERSITY OF THRACE (2008)
- MD
- University of Crete (2003)
Research
Publications
2025
Deupirfenidone Compared to Placebo and Pirfenidone in Idiopathic Pulmonary Fibrosis: ELEVATE IPF Phase 2b Trial
Maher T, Bergna M, Hajari Case A, Choi W, Hamblin M, Kulkarni T, Shore J, Tomos I, Tzouvelekis A, Golod D, Elenko E, Zhang Y, Graham C, Song J, ELEVATE IPF Investigators. Deupirfenidone Compared to Placebo and Pirfenidone in Idiopathic Pulmonary Fibrosis: ELEVATE IPF Phase 2b Trial. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7046-a7046. DOI: 10.1164/ajrccm.2025.211.abstracts.a7046.Peer-Reviewed Original ResearchComplete Blood Cell Count Parameters Predict Mortality in Patients with Hypersensitivity Pneumonitis
Katsaras M, Sotiropoulou V, Manali E, Fouka E, Papakosta D, Bendstrup E, Kolilekas L, Tomos I, Tzilas V, Ntolios P, Steiropoulos P, Papanikolaou I, Gogali A, Kostikas K, Tsiri P, Papaioannou O, Malakounidou E, Theohari E, Christopoulos I, Sampsonas F, Papiris S, Rovina N, Bouros D, Tzouvelekis A. Complete Blood Cell Count Parameters Predict Mortality in Patients with Hypersensitivity Pneumonitis. Diagnostics 2025, 15: 1038. PMID: 40310410, PMCID: PMC12025666, DOI: 10.3390/diagnostics15081038.Peer-Reviewed Original ResearchEosinophil-lymphocyte ratioComplete blood count parametersBlood count parametersHypersensitivity pneumonitisEosinophil countReceiver operating characteristicPrognostic potentialMonocyte countPrognostic biomarkerCount parametersOptimal cut-off thresholdTreatment naive patientsChronic lung diseaseRisk of mortalityIncreased mortality riskWorse survivalClinical courseRetrospective studyLung diseasePredicting mortalityCut-off thresholdsPatientsMonocytesMortality riskEosinophilsBiologic Agents in Idiopathic Hypereosinophilic Syndrome
Papaioannou O, Sampsonas F, Tsiri P, Sotiropoulou V, Christopoulos I, Komninos D, Tzouvelekis A. Biologic Agents in Idiopathic Hypereosinophilic Syndrome. Pharmaceuticals 2025, 18: 543. PMID: 40283978, PMCID: PMC12030681, DOI: 10.3390/ph18040543.Peer-Reviewed Original ResearchIdiopathic hypereosinophilic syndromeHypereosinophilic syndromeDiagnosis of idiopathic hypereosinophilic syndromeBiological agentsToxicities of immunosuppressive agentsHeterogeneous group of rare disordersGroup of rare disordersDrug-related side effectsInitiation of biological agentsMethods:</b> PatientsTreated with mepolizumabEosinophilic pleural effusionValue of eosinophilsEyelid angioedemaOral corticosteroidsImmunosuppressive agentsPleural effusionConcomitant asthmaRare disordersSide effectsCardiac arrhythmiasAsthma flaresPatientsDiagnostic approachFunctional improvementReal-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry
Papaioannou O, Christopoulos I, Tsiri P, Sampsonas F, Karkoulias K, Lykouras D, Sotiropoulou V, Theohari E, Papalexatos D, Komninos D, Christopoulos A, Tzouvelekis A. Real-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry. Journal Of Clinical Medicine 2025, 14: 2174. PMID: 40217624, PMCID: PMC11989620, DOI: 10.3390/jcm14072174.Peer-Reviewed Original ResearchTime of diagnosisOral corticosteroidsSevere asthmaFollow-upBiological agentsBlood eosinophilsAdministration of biological agentsInitiation of biologic treatmentMedian valueTreated with biologic agentsTreated with omalizumabUncontrolled severe asthmaUse of corticosteroidsSevere asthma exacerbationsAsthma outpatient clinicLongitudinal useConsecutive patientsMedian ageDisease phenotypic characteristicsRetrospective studyNever smokersCorticosteroidsAsthma exacerbationsAsthma flaresLung functionInvestigational gene expression inhibitors for the treatment of idiopathic pulmonary fibrosis
Spagnolo P, Tonelli R, Mura M, Reisman W, Sotiropoulou V, Tzouvelekis A. Investigational gene expression inhibitors for the treatment of idiopathic pulmonary fibrosis. Expert Opinion On Investigational Drugs 2025, 34: 61-80. PMID: 39916340, DOI: 10.1080/13543784.2025.2462592.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisGene therapyPulmonary fibrosisAssociated with tolerability issuesProgressive fibrosing interstitial lung diseaseEfficacy of gene therapyApplication of gene therapyTreatment of idiopathic pulmonary fibrosisLong-term clinical dataFibrosing interstitial lung diseaseFirst-line therapyImproved vector designInterstitial lung diseaseMitigate off-target effectsTolerated treatmentDismal prognosisClinical dataLung diseaseClinical studiesAssociated with poor qualityProfibrotic pathwaysTarget cellsTherapyFibrosisOff-target effectsStandard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound
Halim D, Kelly A, Hayes J, Bennett K, Tzouvelekis A, Ampazis D, Sampsonas F. Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound. Medicina 2025, 61: 313. PMID: 40005430, PMCID: PMC11857366, DOI: 10.3390/medicina61020313.Peer-Reviewed Original ResearchConceptsLevels of experienceNon-inferiorityPortable ultrasound deviceOverall image qualityLung pathologyUltrasound deviceInterquartile rangeRespiratory departmentThoracic ultrasoundAnatomical visualizationHandheld ultrasound devicePatient careImprove healthcareOperator's level of experienceNo significant differenceLikert scaleTrainee levelStatistically significant variablesDiagnostic accuracyClinical decisionsOverall perceptionOnline questionnaireClinical utilityMedian rateClinical settingDiagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey
Moen E, Prior T, Kreuter M, Wuyts W, Molina-Molina M, Wijsenbeek M, Morais A, Tzouvelekis A, Ryerson C, Caro F, Buendia-Roldan I, Magnusson J, Lee J, Morisett J, Oldham J, Troy L, Funke-Chambour M, Alberti M, Borie R, Walsh S, Rajan S, Kondoh Y, Khor Y, Bendstrup E. Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey. BMC Pulmonary Medicine 2025, 25: 59. PMID: 39901224, PMCID: PMC11792556, DOI: 10.1186/s12890-025-03532-0.Peer-Reviewed Original ResearchConceptsGenetic testing methodsMultidisciplinary teamGenetic testingFamily historyInterstitial lung diseaseHistory of interstitial lung diseaseRecommended genetic testingScreening of first-degree relativesFamilial interstitial lung diseaseEvidence-based guidelinesGenetic screening of relativesScreening of relativesFirst-degree relativesCharacteristics of respondentsInternational surveyPathogenic genetic variantsScreening toolLung transplantationInsufficient evidenceLung diseaseConsensus statementGenetic variantsFollow-up of patientsStandard programRespondentsInfective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review
Bosgana P, Ampazis D, Vlachakos V, Tzouvelekis A, Sampsonas F. Infective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review. Diagnostics 2025, 15: 145. PMID: 39857029, PMCID: PMC11764001, DOI: 10.3390/diagnostics15020145.Peer-Reviewed Original ResearchEndobronchial ultrasound transbronchial needle aspirationInfective complicationsLung cancerInterventional pulmonology proceduresIncidence of lung cancerNeedle aspirationPrompt treatmentInfective pathologyRisk factorsClinical biomarkersRising incidenceComplicationsRising incidence of lung cancerCancerBiomarkersConcise reviewMediastinumIncreasing numberPatientsLungReviewClinicDiagnosisTranscriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis
Divolis G, Synolaki E, Tringidou R, Tzouvelekis A, Boumpas D, Skendros P, Galani I. Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis. Respiratory Research 2025, 26: 213. PMID: 40500689, PMCID: PMC12160113, DOI: 10.1186/s12931-025-03180-2.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosis patientsIdiopathic pulmonary fibrosisNeutrophil extracellular trapsPulmonary fibrosisIPF pathophysiologyPeripheral blood neutrophil countElevated peripheral blood neutrophil countsAcute respiratory distress syndromeCOVID-19 neutrophilsPeripheral blood of COVID-19 patientsLung biopsy specimensBlood of COVID-19 patientsRespiratory distress syndromeDeregulated immune responseNeutrophil extracellular trap formationBlood neutrophil countNeutrophil-driven pathologiesCOVID-19 pathogenesisCOVID-19 patientsLung biopsyBiopsy specimensDistress syndromePeripheral bloodNeutrophil countActivin/follistatin system
2024
COVID-19 in pregnancy: Perinatal outcomes and complications
Akinosoglou K, Schinas G, Papageorgiou E, Karampitsakos T, Dimakopoulou V, Polyzou E, Tzouvelekis A, Marangos M, Papageorgiou D, Spernovasilis N, Adonakis G. COVID-19 in pregnancy: Perinatal outcomes and complications. World Journal Of Virology 2024, 13: 96573. PMID: 39722762, PMCID: PMC11551681, DOI: 10.5501/wjv.v13.i4.96573.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitPregnant womenPerinatal outcomesGestational agePredictor of adverse fetal outcomesPregnant COVID-19 patientsOutcomes of pregnant womenCare unitAdverse fetal outcomesED presentationsPreterm delivery rateUnfavorable perinatal outcomesEmergency departmentRisk of severe coronavirus disease 2019Severe coronavirus disease 2019Invasive mechanical ventilationDelayed ED presentationsPredictors of hospitalizationFetal outcomesPreterm deliveryPerinatal morbidityCOVID-19 patientsClinical characteristicsTreatment modalities