Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species
Wyllie AL, Pannekoek Y, Bovenkerk S, van Engelsdorp Gastelaars J, Ferwerda B, van de Beek D, Sanders EAM, Trzciński K, van der Ende A. Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species. Open Biology 2017, 7: 170074. PMID: 28931649, PMCID: PMC5627049, DOI: 10.1098/rsob.170074.Peer-Reviewed Original ResearchConceptsSevere streptococcal diseaseUpper respiratory tractHuman upper respiratory tractSerotype-specific assaysMolecular assaysStreptococcal speciesNon-typeable pneumococciStreptococcal diseaseAsymptomatic individualsFalse-positive resultsRespiratory tractPneumococcal isolatesCarriage isolatesStreptococcal isolatesStreptococcus pneumoniaeLack of specificityStreptococciPositive resultsPneumococciDiseaseCarriageAssaysIsolatesVast majorityMeningitis