Pneumococcal genetic variability in age-dependent bacterial carriage
Kremer P, Ferwerda B, Bootsma HJ, Rots NY, Wijmenga-Monsuur AJ, Sanders E, Trzciński K, Wyllie AL, Turner P, van der Ende A, Brouwer MC, Bentley SD, van de Beek D, Lees JA. Pneumococcal genetic variability in age-dependent bacterial carriage. ELife 2022, 11: e69244. PMID: 35881438, PMCID: PMC9395192, DOI: 10.7554/elife.69244.Peer-Reviewed Original ResearchConceptsSecond cohortImproved vaccine formulationsFirst cohortFuture vaccination strategiesSingle nucleotide polymorphismsHost immune factorsAge-specific differencesPneumococcal carriageImmune factorsVaccination strategiesBacterial carriageCarriage studiesVaccine formulationsCohortGenetic factorsAdult hostsSerotypesHost ageAdultsCarriageChildrenGenetic backgroundWeak evidenceInfantsPopulation