Understanding the Barriers to Pooled SARS-CoV-2 Testing in the United States
Fenichel EP, Koch RT, Gilbert A, Gonsalves G, Wyllie AL. Understanding the Barriers to Pooled SARS-CoV-2 Testing in the United States. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00312-21. PMID: 34378949, PMCID: PMC8552767, DOI: 10.1128/spectrum.00312-21.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 testingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detectionPooled testingPooled testing strategyClinical Laboratory Improvement AmendmentsTraditional diagnostic testingEmergence of variantsTesting strategiesDiagnostic testingVirus resurgenceEarly detectionClear protocolsTest capacityTesting capacityUnited StatesTest priceSurveillance measuresTest reportingMajor barrierUptakeAdequate resourcesResponseTestingTesting programU.S. laboratoriesImplementation of a pooled surveillance testing program for asymptomatic SARS-CoV-2 infections in K-12 schools and universities
Mendoza RP, Bi C, Cheng HT, Gabutan E, Pagapas G, Khan N, Hoxie H, Hanna S, Holmes K, Gao N, Lewis R, Wang H, Neumann D, Chan A, Takizawa M, Lowe J, Chen X, Kelly B, Asif A, Barnes K, Khan N, May B, Chowdhury T, Pollonini G, Gouda N, Guy C, Gordon C, Ayoluwa N, Colon E, Miller-Medzon N, Jones S, Hossain R, Dodson A, Weng M, McGaskey M, Vasileva A, Lincoln AE, Sikka R, Wyllie AL, Berke EM, Libien J, Pincus M, Premsrirut PK. Implementation of a pooled surveillance testing program for asymptomatic SARS-CoV-2 infections in K-12 schools and universities. EClinicalMedicine 2021, 38: 101028. PMID: 34308321, PMCID: PMC8286123, DOI: 10.1016/j.eclinm.2021.101028.Peer-Reviewed Original ResearchSARS-CoV-2School transmissionAsymptomatic SARS-CoV-2 infectionRoutine COVID-19 testingSARS-CoV-2 infectionOverall viral burdenCOVID-19 testingViral burdenNasopharyngeal swabsSaliva specimensPrevention protocolsPCR testingKappa agreementWeekly testingCost-effective strategyPooled testingSaliva analysisMolecular assaysSurveillance methodsSafety protocolsDescriptive statisticsSchool closuresTestingStrong evidenceInfection