Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults
Armiyaw L, Sarcone C, Fosam A, Muniyappa R. Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa234. PMID: 32382759, PMCID: PMC7266075, DOI: 10.1210/clinem/dgaa234.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesTotal β-cell responsivityΒ-cell responsivityPrimary insulin hypersecretionGlucose disposal rateInsulin sensitivityInsulin hypersecretionAfrican AmericansBasal insulin secretion rateGlucose responsivityIntravenous glucose tolerance testGlucose tolerance testHyperinsulinemic euglycemic glucose clamp techniqueC-peptide secretionGlucose clamp techniqueInsulin secretion rateNondiabetic African AmericansΒ-cell functionAfrican American adultsInsulin resistanceTolerance testNHW subjectsC-peptideInsulin secretionSignificant ethnic differencesReduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans
Fosam A, Sikder S, Abel B, Tella S, Walter M, Mari A, Muniyappa R. Reduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa070. PMID: 32052016, PMCID: PMC7059993, DOI: 10.1210/clinem/dgaa070.Peer-Reviewed Original Research