2019
Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
Arnsten AFT, Datta D, Leslie S, Yang ST, Wang M, Nairn AC. Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26230-26238. PMID: 31871209, PMCID: PMC6936707, DOI: 10.1073/pnas.1903671116.Peer-Reviewed Original ResearchTau pathologyAlzheimer's diseaseAssociation cortexTau phosphorylationMouse modelRhesus monkeysSignificant amyloid pathologyAlzheimer-like pathologyPrefrontal association cortexTau phosphorylation statePrimary sensory cortexOnset Alzheimer's diseasePrecursor protein cleavagePreventive therapyAmyloid pathologyCalcium dysregulationEarly stage degenerationPhosphorylated tauPrecipitating factorsSensory cortexCognitive deficitsAD researchRhesus macaquesPathologyCortex
2014
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 5036-5041. PMID: 24707050, PMCID: PMC3977284, DOI: 10.1073/pnas.1322360111.Peer-Reviewed Original ResearchConceptsNeurofibrillary tanglesAssociation cortexAlzheimer's diseaseSpine apparatusPhosphorylated tauPattern of neurodegenerationLate-stage diseaseHigh-risk factorsNormal aged miceGenetic rodent modelsPrefrontal association cortexPrimary sensory cortexPrimary visual cortexAge-related increasePyramidal neuronsCorticocortical connectionsAged miceRisk factorsGlutamate synapsesSpine synapsesSelective vulnerabilityRodent modelsDendritic spinesSensory cortexProtein kinase phosphorylation