2023
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation
Jing J, Ge W, Hong S, Fernandes M, Lin Z, Yang C, An S, Struck A, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology 2023, 100: e1750-e1762. PMID: 36878708, PMCID: PMC10136013, DOI: 10.1212/wnl.0000000000207127.Peer-Reviewed Original Research
2022
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs
Jing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.Peer-Reviewed Original ResearchConceptsGeneralized rhythmic delta activityLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityDelta activityPeriodic dischargesClass II evidencePrimary outcome measureMassachusetts General HospitalContributions of biasCritical illnessSecondary outcomesMedian ageInterrater reliability studyClinical indicationsGeneral HospitalMedian numberOutcome measuresProspective analysisExpert consensusSeizuresBrain monitoringInterrater reliabilityBrain activitySelection bias
2020
Deep active learning for Interictal Ictal Injury Continuum EEG patterns
Ge W, Jing J, An S, Herlopian A, Ng M, Struck AF, Appavu B, Johnson EL, Osman G, Haider HA, Karakis I, Kim JA, Halford JJ, Dhakar MB, Sarkis RA, Swisher CB, Schmitt S, Lee JW, Tabaeizadeh M, Rodriguez A, Gaspard N, Gilmore E, Herman ST, Kaplan PW, Pathmanathan J, Hong S, Rosenthal ES, Zafar S, Sun J, Westover M. Deep active learning for Interictal Ictal Injury Continuum EEG patterns. Journal Of Neuroscience Methods 2020, 351: 108966. PMID: 33131680, PMCID: PMC8135050, DOI: 10.1016/j.jneumeth.2020.108966.Peer-Reviewed Original ResearchConceptsConvolutional neural networkIll patientsActive learningLarge labeled datasetExpert-level performanceDeep active learningLarge EEG datasetsPseudo-labeled dataUse of ALElectroencephalography patternsPatient careQuery criteriaLabeled datasetLabel spreadingEEG patternsPatientsExpert labelsClass balancingNeural networkAvailable labelsVector representationQueriesInformative examplesAL approachEEG datasetCannabidiol in treatment of refractory epileptic spasms: An open-label study
Herlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.Peer-Reviewed Original ResearchConceptsRefractory epileptic spasmsEpileptic spasmsResponder rateAdjunctive therapyCBD treatmentInvestigational new drug trialsOpen-label studyMonths of treatmentSafe adjunctive therapyNew drug trialsInstitutional review boardSubjective reportsBaseline medicationsCBD initiationElectrographic findingsHypsarrhythmia patternClinical responseSeizure frequencyAdverse eventsClinical efficacyElectrographic changesSubjective improvementTarget dosageDrug trialsInitial dosage