Alexa Siddon, MD
Cards
Appointments
Titles
Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory Medicine
Contact Info
Laboratory Medicine
330 Cedar Street, PO Box 208035
New Haven, CT 06520-8035
United States
Appointments
Titles
Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory Medicine
Contact Info
Laboratory Medicine
330 Cedar Street, PO Box 208035
New Haven, CT 06520-8035
United States
Appointments
Titles
Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory Medicine
Contact Info
Laboratory Medicine
330 Cedar Street, PO Box 208035
New Haven, CT 06520-8035
United States
About
Titles
Professor of Laboratory Medicine
Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory MedicineAppointments
Laboratory Medicine
ProfessorPrimaryPathology
Associate Professor on TermSecondary
Other Departments & Organizations
- Blue College Affiliates
- Cancer Immunology
- Center for Biomedical Data Science
- Clinical Flow Cytometry Laboratory
- Hematopathology
- Hematopathology
- Laboratory Medicine
- Laboratory Medicine - Education
- Molecular Diagnostics Laboratory
- Pathology
- Pathology and Molecular Medicine
- Surgical Pathology
- Yale Cancer Center
- Yale Medicine
Education & Training
- Fellowship
- Yale University School of Medicine (2013)
- Residency
- Yale University School of Medicine (2012)
- MD
- SUNY Upstate Medical University (2008)
- BA
- Hamilton College (2004)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Henry Rinder, MD
Nikolai Podoltsev, MD, PhD
Richard Torres, MD, MS, BS
Brian Richard Smith, MD
Lohith Gowda, MD, MRCP
Rory Shallis, MD
Publications
Myelodysplastic Syndromes
Siddon A. Myelodysplastic Syndromes. Clinics In Laboratory Medicine 2023, 43: i. DOI: 10.1016/s0272-2712(23)00095-1.Peer-Reviewed Original ResearchAltmetricAdvances in Myelodysplastic Syndromes
Siddon A. Advances in Myelodysplastic Syndromes. Clinics In Laboratory Medicine 2023, 43: xiii-xiv. PMID: 37865512, DOI: 10.1016/j.cll.2023.08.015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsDiagnosis and Classification of Myelodysplastic Syndromes with Mutated TP53
Siddon A, Weinberg O. Diagnosis and Classification of Myelodysplastic Syndromes with Mutated TP53. Clinics In Laboratory Medicine 2023, 43: 607-614. PMID: 37865506, DOI: 10.1016/j.cll.2023.07.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute myeloid leukemiaMyelodysplastic syndromeTP53 mutationsPrognosis of MDSCases of MDSPrognostic scoring systemNext-generation sequencingParticular next-generation sequencingAggressive diseasePoor outcomeTherapeutic managementTP53 disruptionMyeloid leukemiaMyeloid neoplasmsTherapeutic advancementsCytogenetic abnormalitiesMyeloid neoplasiaScoring systemDisease classificationMyeloid diseasesGene mutationsSyndromeDiseaseDiagnosisTP53Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report
Lee T, Aisner D, David M, Eno C, Gagan J, Gocke C, Guseva N, Haley L, Jajosky A, Jones D, Mansukhani M, Mroz P, Murray S, Newsom K, Paulson V, Roy S, Rushton C, Segal J, Senaratne T, Siddon A, Starostik P, Van Ziffle J, Wu D, Xian R, Yohe S, Kim A. Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report. Blood Advances 2023, 7: 4599-4607. PMID: 37236162, PMCID: PMC10425685, DOI: 10.1182/bloodadvances.2023010149.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMolecular testingAcute casesHematologic malignanciesRapid turnaround timeTertiary care laboratoryAcute myeloid leukemiaCurrent clinical practiceMyeloid leukemiaTurnaround timeLymphoid processesClinical practicePatient careNGS panelCalendar daysClinical expectationsWorking Group ReportMost survey respondentsMalignancyCareReimbursementCase reimbursementSurvey respondentsGroup ReportTesting practicesDaysHelicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis
Gu S, Siddon A, Huntington S, Jain D. Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis. American Journal Of Clinical Pathology 2023, 160: 612-619. PMID: 37556379, PMCID: PMC10691190, DOI: 10.1093/ajcp/aqad088.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHP-positive patientsLymphoid tissue lymphomaChronic gastritisMALT lymphomaHP-negative casesTissue lymphomaHelicobacter pylori-negative mucosaPrimary gastric MALT lymphomaB-cell gene rearrangementsAvailable pathology reportsHP-negative patientsGastric MALT lymphomaHP-negative groupHelicobacter pylori infectionReview of slidesMALT lymphoma casesAdditional laboratory testingHP eradicationDisease recurrenceOptimal management strategyClinicopathologic analysisClinicopathologic featuresHistologic gastritisHP-positive casesInitial diagnosisMolecular Techniques and Gene Mutations in Myelodysplastic Syndromes
Mendoza H, Siddon A. Molecular Techniques and Gene Mutations in Myelodysplastic Syndromes. Clinics In Laboratory Medicine 2023, 43: 549-563. PMID: 37865502, DOI: 10.1016/j.cll.2023.06.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMolecular findings in myeloid neoplasms
Tran T, Siddon A. Molecular findings in myeloid neoplasms. International Journal Of Laboratory Hematology 2023, 45: 442-448. PMID: 37345257, DOI: 10.1111/ijlh.14118.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute myeloid leukemiaMyeloid neoplasmsNext-generation sequencingMyeloproliferative neoplasmsInternational diagnostic guidelinesSomatic gene mutationsHematologic cancersMyeloid leukemiaDiagnostic guidelinesClinical relevanceMyeloid disordersPatient careNeoplasmsCytogenetic findingsMolecular findingsGene mutationsNew molecular technologiesMolecular technologiesMutationsLeukemiaCancerPrognosticationCliniciansFindingsModifier mutationsOptimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms
Puzo C, Tormey C, Rinder H, Siddon A. Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms. Transplantation And Cellular Therapy 2023, 29: 459.e1-459.e4. PMID: 37062510, DOI: 10.1016/j.jtct.2023.04.005.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAllogeneic stem cell transplantationStem cell transplantationDonor chimerismCell transplantationNGS testingPost allogeneic stem cell transplantationMeasurable residual diseaseNext-generation sequencingAcute myeloid leukemiaConditioning regimenRelated donorsMyelodysplastic syndromeResidual diseaseValidation cohortMyeloid leukemiaMyeloid neoplasmsNGS panelLogistic regressionPatientsChimerismSignificant predictorsCharacteristic curveTransplantationRegimenConservative thresholdMyeloid sarcoma with NPM1 mutation may be clinically and genetically distinct from AML with NPM1 mutation: a study from the Bone Marrow Pathology Group
de M, Wu L, Hirt C, Pihan G, Patel S, Tam W, Bueso-Ramos C, Kanagal-Shamanna R, Raess P, Siddon A, Narayanan D, Morgan E, Pinkus G, Mason E, Hsi E, Rogers H, Toth L, Foucar K, Hurwitz S, Bagg A, Rets A, George T, Orazi A, Arber D, Hasserjian R, Weinberg O, Group F. Myeloid sarcoma with NPM1 mutation may be clinically and genetically distinct from AML with NPM1 mutation: a study from the Bone Marrow Pathology Group. Leukemia & Lymphoma 2023, 64: 972-980. PMID: 36960680, DOI: 10.1080/10428194.2023.2185091.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute myeloid leukemiaMyeloid sarcomaOverall survivalNPM1 mutationsDe novo acute myeloid leukemiaBone Marrow Pathology GroupMulti-institutional cohort studyNovo acute myeloid leukemiaRetrospective multi-institutional cohort studyShorter overall survivalPoor overall survivalFrequent cytogenetic abnormalityCohort studyMyeloid leukemiaPathology groupCytogenetic abnormalitiesComplex karyotypeUnique genetic landscapeMutations of genesGene mutationsSarcomaGenetic landscapeHigher average numberMutationsLeukemiaQuantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants
Khan W, Tormey C, Rinder H, Siddon A. Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants. American Journal Of Clinical Pathology 2023, 159: 417-419. PMID: 36940149, DOI: 10.1093/ajcp/aqac183.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and Concepts
Academic Achievements and Community Involvement
honor The Donald H. Buchholz Research Prize
Yale School of Medicine AwardDept. of Laboratory Medicine, Yale School of MedicineDetails06/20/2011United Stateshonor Paul J. Strandjord Young Investigator Award
National AwardAcademy of Clinical Laboratory Physicians and ScientistsDetails06/01/2010United States
Clinical Care
Overview
Alexa Siddon, MD, is a pathologist who specializes in diagnosing diseases of the blood, such as leukemia and disorders, including bone marrow failure. Her interest in medicine began at a young age, when she accompanied her mother to the workplace—a clinical laboratory. In college, Dr. Siddon completed emergency medical technician (EMT) training and, later, decided to attend medical school.
“I chose pathology because I enjoy putting together the entire story of a patient to make a diagnosis,” says Dr. Siddon, who directs the hemopathology lab at the Veteran Affairs Connecticut Healthcare System. When examining patient samples, Dr. Siddon relies on an arsenal of sophisticated tools to make an accurate diagnosis. “For example, we might look at a bone marrow sample under a microscope, and we would also do genetic sequencing to see if we can discover genetic mutations that might make the patient eligible for a clinical trial.”
“My main focus is patient care,” Dr. Siddon says. “The more information I can give our colleagues, including hematology oncologists, the better care they can provide.”
At Yale School of Medicine, Dr. Siddon is an assistant professor of laboratory medicine.
Clinical Specialties
Fact Sheets
Cytogenic Studies for Leukemia Diagnosis
Learn More on Yale MedicineDiagnosing Leukemia
Learn More on Yale Medicine
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2012
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Contacts
Laboratory Medicine
330 Cedar Street, PO Box 208035
New Haven, CT 06520-8035
United States
Locations
Department of Laboratory Medicine
Academic Office
55 Park Street, Rm 435B
New Haven, CT 06511
Clinical Inquiry
203.688.4977