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Cecilia Canessa, MD

Professor of Cellular And Molecular Physiology
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Contact Info

Cellular & Molecular Physiology

PO Box 208026, 333 Cedar Street

New Haven, CT 06520-8026

United States

About

Titles

Professor of Cellular And Molecular Physiology

Appointments

Education & Training

MD
Cayetano Heredia University Lima (1982)
Residency
Henepin County Medical Center, University of Minnesota
Fellowship
Univerisity of Alabama

Research

Overview

In
our laboratory we examine the structure, function and regulation of two
types of sodium channels: the Epithelial Na + Channel (ENaC) and Acid
Sensing Ion Channels (ASIC). These proteins are structurally related
but serve very different functions. ENaC is expressed in the apical
side of epithelial cells involved in sodium absorption such as in
kidney, lung and colon. Mutations in the human ENaC genes produce
disorders of whole-body sodium balance and are characterized by
hypertension or sodium wasting. Our current work centers on mechanisms
that regulate activity, expression and traffic of ENaC in epithelial
cells specifically, on the role of a kinase known as serum-and
glucocorticoid-induced kinase or Sgk1.

The
ASICs are expressed in neurons of the central and peripheral nervous
systems. External protons gate ASIC but other stimuli are likely to be
more important physiological agonists. These channels have been
implicated in many functions including nociception, mechanoperception
and modulation of synaptic transmission. Our work centers in the
elucidation of the biophysical properties and gating of ASICs from many
vertebrate species.


We
use a broad range of experimental approaches and techniques that
include electrophysiology (patch-clamp, two-electrode voltage clamp,
short-circuit current), cloning of channels from evolutionary distant
species, modifications of channels and their expression in oocytes,
cell lines and in mice either trangenics or knockins.

Medical Subject Headings (MeSH)

Central Nervous System; Electrophysiology; Epithelial Sodium Channels; Kidney; Nephrology; Physiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Cecilia Canessa's published research.

Publications

2023

2019

2013

2011

2010

2009

2008

2007

2006

Get In Touch

Contacts

Mailing Address

Cellular & Molecular Physiology

PO Box 208026, 333 Cedar Street

New Haven, CT 06520-8026

United States