Dean’s Workshop: Modeling Human Disease Using the Yale Zebrafish Phenotyping Core
Friday, February 28, 2020, 1:00 - 5:00 PM, Brady Auditorium B131
Light refreshments will be provided.
The newly established Yale Zebrafish Phenotyping Core now makes it possible for Yale researchers to study novel disease-causing mutations in a new verte- brate model. Zebrafish present a compelling alterna- tive to other model systems given their high fertility, large brood size, small larvae, rapid maturation, and physical transparency. Behavioral phenotypes com- pare against well-established zebrafish behaviors for swimming, learning, sleep, vision, avoidance, olfaction, reward, and social preference. It is also straightforward to visualize molecular phenotypes in zebrafish using microscopy with genetically encoded fluorescent reporters, in vivo stains, and immunohistochemical stains. Their small size makes high throughput screens accessible in zebrafish to identify small molecules protective in disease models, a further application for human disease modeling.
This workshop spotlights investigators at Yale currently using the core or the zebrafish model system to illustrate its power. Presenters will describe their applications involving zebrafish models in the fields of cell biology, genetics, cardiovascular research, and neuroscience.
WELCOMING REMARKS, 1:00 PM
Michael Crair, PhD
William Ziegler III Professor of Neuroscience and Professor of Ophthalmology and Visual Science; Deputy Dean for Scientific Affairs (Basic Science Departments); Yale School of Medicine
TOPICS IN GENETICS AND RARE DISEASES, 1:20 PM
Yong-Hui Jiang, MD, PhD
Chief of Medical Genetics, Yale School of Medicine
DISEASE MODELS IN ZEBRAFISH, 1:40 PM
Stefania Nicoli, PhD
Associate Professor Term, Cardiovascular Medicine and Genetics, Yale School of Medicine
Zhaoxia Sun, PhD
Associate Professor of Genetics, Yale School of Medicine
Keiichiro Tanaka, PhD
Associate Research Scientist of Medicine (Cardiovascular) in the Laboratory of Martin Schwartz, Cardiovascular Medicine, Yale School of Medicine
Valerie Tornini, PhD
Postdoctoral Fellow in the Laboratory of Antonio Giraldez, Genetics, Yale School of Medicine
OVERVIEW OF THE ZEBRAFISH PHENOTYPING CORE, 3:00 PM
Andrew Prendergast, PhD
Associate Research Scientist, Scientific Project Manager, Yale Zebrafish Phenotyping Core, Cardiovascular Medicine, Yale School of Medicine
COFFEE BREAK, 3:30 PM
PLENARY SPEAKER, 4:00 PM
Brian Ciruna, PhD
Head and Senior Scientist, Developmental & Stem Cell Biology, The Hospital for Sick Children; Professor, Department of Molecular Genetics, University of Toronto
CLOSING REMARKS
Website: medicine.yale.edu/zebrafish/
Contact: andrew.e.prendergast@yale.edu
Dean’s Workshop Contact: beth.pranger@yale.edu
Sponsored by the Office of the Dean, Yale School of Medicine. Program details are online here.