Yale School of Medicine - For Humanity: Inflammation Pillar
December 19, 2023ID11110
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- 00:00As creative leaders in medicine and science,
- 00:04we constantly push boundaries to advance
- 00:06medicine for the benefit of humanity.
- 00:09We are at the leading edge of a
- 00:11new understanding of inflammation's
- 00:13role in human health, aging,
- 00:15and diseases such as Alzheimer's,
- 00:17multiple sclerosis, cancer, and more.
- 00:19I can't think of a single
- 00:22disease that doesn't involve
- 00:23inflammation in some way,
- 00:25for example. Currently,
- 00:26we're working on understanding sepsis,
- 00:28which is one of the.
- 00:30Clinically, extremely difficult
- 00:32conditions with high rate of mortality.
- 00:35We're discovering some simple ways
- 00:37to manipulate the inflammatory
- 00:39response under these conditions that
- 00:41result in improvement and survival.
- 00:43I think our work collectively
- 00:45on inflammation is impacting people's
- 00:47lives in a very tangible manner.
- 00:49We have started a PAC Slovak trial
- 00:52for treating patients with bone COVID
- 00:55with Doctor Hall from Health Group
- 00:57to look for biomarkers of people who
- 01:00respond positively so we can learn
- 01:02about the biology of this disease.
- 01:05As well as who benefits from Pak
- 01:08Sloven treatment or other antivirals.
- 01:10So we're studying specifically how
- 01:12the host age determines how we
- 01:15respond to different inflammatory
- 01:17signals such as viral infection,
- 01:19a process called inflammation,
- 01:21which means as we get older and older,
- 01:25our immune system is more prone
- 01:27to the inflammatory activation.
- 01:29Now that we understand these issues,
- 01:32we can try to better target therapeutics.
- 01:35Research at Yale Medical School has
- 01:37really been at the forefront of this
- 01:39movement and making new discoveries.
- 01:41That inform this new perspective on
- 01:44information and its role in aging
- 01:46and in diseases in general,
- 01:48neurodegenerative diseases like
- 01:50the Alzheimer's disease, as well as
- 01:52cancers, because in the case of cancers,
- 01:55inflammation plays a really dominant
- 01:57role in driving the development.
- 01:59Here at the old medical school,
- 02:02we are learning of the ways to either
- 02:05promote information when it's helpful or
- 02:07to suppress it when it's unhelpful. I've
- 02:10been very fortunate to have many
- 02:13collaborators across different
- 02:14discipline where we can ask very
- 02:17important questions that will hopefully
- 02:19directly help the patients. A
- 02:22gift to study inflammation will
- 02:23go a long way in fostering even
- 02:26more collaboration across the
- 02:27school and internationally,
- 02:29and that is potentially going
- 02:31to give us a leap that we need.
- 02:34To revolutionize this whole science
- 02:36on inflammation, Learn how your
- 02:38gift can help advance our understanding
- 02:40of inflammation with the goal of
- 02:42developing breakthrough treatments.
- 02:44Connect with a Development Officer today.