Paul Heerdt, PhD, MD
Professor of AnesthesiologyCards
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, Anesthesiology
Biography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- Intern
- Blodgett Memorial Medical Center (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9765-9885
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Phillip Joseph, MD
Edward Manning, MD, PhD
George Tellides, MD, PhD
Lissa Sugeng, MD, MPH
Naftali Kaminski, MD
Cardiovascular Diseases
Publications
2025
Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived exertionMET assessmentStructured surveyCapacity surveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteriaBiventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis
Araos J, Glocker F, Owyang C, Teran F, Kim J, Nieman G, Heerdt P. Biventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis. Anesthesiology 2025, 142: 767-769. PMID: 39946198, DOI: 10.1097/aln.0000000000005363.Peer-Reviewed Original ResearchDeep learning-based measurement of isovolumic relaxation time from cardiovascular magnetic resonance long-axis cines: Validation with pressure-derived IVRT
Barrientos L, Gonzales R, Lamy J, Seemann F, Mojibian H, Heerdt P, Singh I, Peters D. Deep learning-based measurement of isovolumic relaxation time from cardiovascular magnetic resonance long-axis cines: Validation with pressure-derived IVRT. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101286. DOI: 10.1016/j.jocmr.2024.101286.Peer-Reviewed Original Research
2024
Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the 6-Minute Walk Test.
Kremer N, Schaefer S, Yogeswaran A, Rako Z, Ghofrani H, Seeger W, Kojonazarov B, Heerdt P, Tedford R, Tello K. Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the 6-Minute Walk Test. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1486-1490. PMID: 39404674, DOI: 10.1164/rccm.202407-1397rl.Peer-Reviewed Original ResearchThe metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchConceptsPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchManagement of Respiratory Failure in Hemorrhagic Shock.
Davis J, Manoach S, Heerdt P, Berlin D. Management of Respiratory Failure in Hemorrhagic Shock. Annals Of The American Thoracic Society 2024, 21: 993-997. PMID: 38669620, DOI: 10.1513/annalsats.202310-905cme.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMechanical ventilationHemorrhagic shockInadequate pulmonary blood flowTreated with fluid resuscitationManagement of respiratory failureMean airway pressurePulmonary blood flowPositive pressure ventilationIncreased minute ventilationRespiratory muscle fatigueAirway pressureDead space fractionRespiratory failureFluid resuscitationPressure ventilationSevere hypovolemiaVenous returnCardiac outputMinute ventilationBlood flowVentilationSpace fractionCliniciansHypovolemiaHypoperfusionTime domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs
Keast T, Glass A, McCall P, Heerdt P, Shelley B. Time domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs. British Journal Of Anaesthesia 2024, 132: 1009. DOI: 10.1016/j.bja.2024.01.027.Peer-Reviewed Original ResearchThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchRight Ventriculoarterial Coupling During Positive End-expiratory Pressure Titration Based on a Pressure-based Single Beat Method: A Proof-of-Concept Study
Araos J, Owyang C, Martin-Flores M, Teran F, Kim J, Retamal Montes J, Notarianni A, Heerdt P. Right Ventriculoarterial Coupling During Positive End-expiratory Pressure Titration Based on a Pressure-based Single Beat Method: A Proof-of-Concept Study. 2024, a3477-a3477. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3477.Peer-Reviewed Original Research
News
News
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- September 16, 2021
Discoveries & Impact (September 2021)
- September 29, 2020
Yale Department of Anesthesiology 5th Annual Celebration of Research 2020