Paul Heerdt, PhD, MD
Professor of AnesthesiologyCards
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
Copy Link
Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, Anesthesiology
Biography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- Intern
- Blodgett Memorial Medical Center (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
Copy Link
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9765-9885
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Phillip Joseph, MD
Edward Manning, MD, PhD
George Tellides, MD, PhD
Naftali Kaminski, MD
Zyad James Carr, MD
Cardiovascular Diseases
Publications
2025
Method for generating right ventricular pressure–volume loops in routine practice
Kremer N, Glocker F, Schaefer S, Janetzko P, Yogeswaran A, Rako Z, Thal B, Hopf H, Seeger W, Ghofrani H, Heerdt P, Tello K. Method for generating right ventricular pressure–volume loops in routine practice. The Journal Of Heart And Lung Transplantation 2025 PMID: 40947078, DOI: 10.1016/j.healun.2025.09.002.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRoutine right heart catheterizationEnd-diastolic volumeConductance catheterizationEjection fractionFeasibility cohortStroke workRight ventricular pressure-volume loopsRight ventricular (RV) functionClinical cohortStroke volumeRight heart catheterizationBland-Altman analysisPreclinical cohortPV loopsEnd-systolic elastanceRV volumesHeart catheterizationPulmonary hypertensionVentricular pressure-volume loopsPressure-volume loopsRoutine clinical workflowCatheterizationGold standardClinical implementationArterial elastance“Right Ventricular Function and Echocardiographic Pressure-Volume Loops” There is More to the Story
Heerdt P, Kariya T. “Right Ventricular Function and Echocardiographic Pressure-Volume Loops” There is More to the Story. Journal Of Cardiothoracic And Vascular Anesthesia 2025 DOI: 10.1053/j.jvca.2025.08.057.Peer-Reviewed Original ResearchThe Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease
Manning E, Lee S, Ashadujjaman M, De Man R, Cai Z, Adams T, Raredon M, Ramachandra A, Cavinato C, Heerdt P, Singh I, Choudhary G, Yan X, Bellini C, Tellides G, Humphrey J, Kaminski N. The Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2891-a2891. DOI: 10.1164/ajrccm.2025.211.abstracts.a2891.Peer-Reviewed Original ResearchIntegrative Plasma Multi-Omics Profiling Reveals Novel Mechanisms of Pulmonary Arterial Hypertension
Kheyfets V, Sweatt A, Zhang H, Nemkov T, Aizin M, Heerdt P, Dzieciatkowska M, Stephenson D, LaCroix I, D'Alessandro A, Oldham W, Hansen K, Zamanian R, Stenmark K. Integrative Plasma Multi-Omics Profiling Reveals Novel Mechanisms of Pulmonary Arterial Hypertension. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7246-a7246. DOI: 10.1164/ajrccm.2025.211.abstracts.a7246.Peer-Reviewed Original ResearchPreoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications
Carr Z, Charchaflieh J, Brenes-Bastos A, He H, Lin H, Jankelovits A, Gu E, Zafar J, Ghali F, Tan W, Heerdt P. Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open 2025, 14: 100407. PMID: 40421445, PMCID: PMC12105740, DOI: 10.1016/j.bjao.2025.100407.Peer-Reviewed Original ResearchAltmetricConceptsLength of staySubmaximal cardiopulmonary exercise testingInstitutional review board approvalPostoperative complication riskReview board approvalDuke Activity Status IndexCardiopulmonary exercise testingIncreased length of stayAdjusted multivariable regression modelsPostoperative complications predictionPulmonary capacitanceOpen-labelPeak oxygen uptakePerioperative surveillancePrimary endpointNoncardiac surgeryPostoperative complicationsSecondary endpointsSingle-centreComplication riskMET assessmentPeak VOBoard approvalMultivariate regression modelMetabolic equivalentsImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived ExertionMET assessmentStructured surveyCapacity SurveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteriaBiventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis
Araos J, Glocker F, Owyang C, Teran F, Kim J, Nieman G, Heerdt P. Biventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis. Anesthesiology 2025, 142: 767-769. PMID: 39946198, DOI: 10.1097/aln.0000000000005363.Peer-Reviewed Original ResearchCitationsAltmetricDeep learning-based measurement of isovolumic relaxation time from cardiovascular magnetic resonance long-axis cines: Validation with pressure-derived IVRT
Barrientos L, Gonzales R, Lamy J, Seemann F, Mojibian H, Heerdt P, Singh I, Peters D. Deep learning-based measurement of isovolumic relaxation time from cardiovascular magnetic resonance long-axis cines: Validation with pressure-derived IVRT. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101286. DOI: 10.1016/j.jocmr.2024.101286.Peer-Reviewed Original Research
2024
Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the 6-Minute Walk Test.
Kremer N, Schaefer S, Yogeswaran A, Rako Z, Ghofrani H, Seeger W, Kojonazarov B, Heerdt P, Tedford R, Tello K. Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the 6-Minute Walk Test. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1486-1490. PMID: 39404674, DOI: 10.1164/rccm.202407-1397rl.Peer-Reviewed Original ResearchCitationsThe metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeak VO2Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairment
News
Copy Link
Get In Touch
Copy Link