George Tellides, MD, PhD
Professor of Surgery (Cardiac)Cards
About
Titles
Professor of Surgery (Cardiac)
Biography
George Tellides, MD, PhD, earned his medical degree from the University of Witwatersrand, Johannesburg, and his PhD from the University of Oxford. Dr. Tellidies is dedicated to saving and improving the lives of patients with cardiac disease and heart failure and concentrates his clinical practice at the Veterans Affairs Medical Center, West Haven, CT.
Last Updated on April 07, 2025.
Appointments
Cardiac Surgery
ProfessorPrimary
Other Departments & Organizations
- Cardiac Surgery
- Investigative Medicine Program
- Nuclear & Stress Testing
- Surgery
- Vascular Biology and Therapeutics Program
- Yale Ventures
Education & Training
- Chief Resident
- Harvard Medical School, Brigham and Women's Hospital, Boston, MA (1995)
- Resident
- Brigham and Women's Hospital and Children'sHospital, Harvard Medical School, Boston, MA (1994)
- Chief Resident
- Yale School of Medicine, Yale-New Haven Hospital, New Haven, CT (1993)
- Resident
- Yale School of Medicine, Yale-New Haven Hospital, New Haven, CT (1992)
- PhD
- University of Oxford (1988)
- Research Fellow
- John Radcliffe Hospital, University of Oxford, Oxford, England (1988)
- MD
- University of Witwatersrand (1983)
Board Certifications
Thoracic Surgery
- Certification Organization
- AB of Thoracic Surgery
- Original Certification Date
- 1996
Surgery
- Certification Organization
- AB of Surgery
- Original Certification Date
- 1994
Research
Publications
2026
Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober J, Jane-wit D. Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nature Communications 2026, 17: 4777. PMID: 42209477, PMCID: PMC13219585, DOI: 10.1038/s41467-026-73044-w.Commentaries, Editorials and LettersShear Preconditioning Restores Endothelial Function of HLHS Patient-Derived iPSC-ECs for Successful Conduit Implantation
Zhang W, Qin L, Fooladi S, Ménoret S, Johns A, Anegon I, Nelson T, Tellides G, Qyang Y. Shear Preconditioning Restores Endothelial Function of HLHS Patient-Derived iPSC-ECs for Successful Conduit Implantation. Arteriosclerosis Thrombosis And Vascular Biology 2026, 46: e324018. PMID: 42021735, DOI: 10.1161/atvbaha.125.324018.Commentaries, Editorials and LettersFOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis
Deng H, Zhang X, Wang Y, Joshi D, Tellides G, Schwartz M. FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis. Circulation Research 2026, 138: e327592. PMID: 41738126, PMCID: PMC12989233, DOI: 10.1161/circresaha.125.327592.Peer-Reviewed Original ResearchProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchSphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization
Saito J, Dave J, Gallardo-Vara E, Sadagopan N, Kabir I, Tellides G, Riemer R, Urban Z, Spiegel S, Hla T, Greif D. Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization. Nature Cardiovascular Research 2026, 5: 34-50. PMID: 41492020, PMCID: PMC13091694, DOI: 10.1038/s44161-025-00762-7.Peer-Reviewed Original Research
2025
Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
Gao F, Chen Q, Mori M, Li S, Ferrari G, Krane M, Fan R, Tellides G, Liu Y, Geirsson A. Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice. Journal Of Clinical Investigation 2025, 135: e183558. PMID: 40392604, PMCID: PMC12259269, DOI: 10.1172/jci183558.Peer-Reviewed Original ResearchShort-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodríguez M, Chen Y, Ramachandra A, Li G, Qin L, Assi R, Schwartz M, Humphrey J, Tellides G. Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. JCI Insight 2025, 10: e182629. PMID: 39932797, PMCID: PMC11949005, DOI: 10.1172/jci.insight.182629.Peer-Reviewed Original Research
2024
Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption
Ren P, Jiang B, Hassab A, Li G, Li W, Assi R, Tellides G. Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption. Arteriosclerosis Thrombosis And Vascular Biology 2024, 45: 260-276. PMID: 39697172, PMCID: PMC12053597, DOI: 10.1161/atvbaha.124.321706.Peer-Reviewed Original ResearchAnimalsAortaAortic AneurysmCell LineageDisease Models, AnimalGene Expression ProfilingHomeobox Protein Nkx-2.5HumansMaleMarfan SyndromeMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleMyosin Heavy ChainsNeural CrestPhenotypeReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionSingle-Cell AnalysisTranscription, GeneticTranscriptomeTransforming Growth Factor betaWnt1 ProteinVascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering
Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon M, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs D, Tellides G, Anegon I, Pober J, Liu P, Qyang Y. Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Acta Biomaterialia 2024, 193: 171-184. PMID: 39681154, PMCID: PMC12212065, DOI: 10.1016/j.actbio.2024.12.033.Peer-Reviewed Original ResearchFully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural M, Li X, Luo H, Xu Z, Wang J, Banno K, Gu S, Yuan Y, Anderson C, Ellis M, Zhou J, Luo J, Shi X, Shin J, Liu Y, Lee S, Yoder M, Elder R, Mak M, Thorn S, Sinusas A, Gruber P, Hwa J, Tellides G, Niklason L, Qyang Y. Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Cell Stem Cell 2024, 32: 137-143.e6. PMID: 39644899, PMCID: PMC11698629, DOI: 10.1016/j.stem.2024.11.006.Peer-Reviewed Original Research
News & Links
Media
News
- January 22, 2026
Researchers Uncover Potential Pathway To Address Williams-Beuren Syndrome
- September 20, 2024
What Gets Lost When Autopsies Aren’t Done? Not Just Cause of Death
- March 11, 2024
Engineering a Heart Conduit: New $2M NIH Grant for Yale Research
- May 12, 2023
Targeting Fibronectin-integrin α5 Signaling in Marfan Syndrome
Get In Touch
Contacts
Academic Office Number
Mailing Address
Cardiac Surgery
PO Box 208062
New Haven, CT 06520-8062
United States