Genetics Seminar Series: "Dissecting the 3D genome's structure-function relationship in transcription, replication, and genome instability"

The Cremins lab aims to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, and induced pluripotent stem cell differentiation to neurons/organoids. We have developed molecular and computational technologies to create kilobase-resolution maps of chromatin folding and have built synthetic architectural proteins to engineer loops with light, together catalyzing new understanding of the genome’s structure-function relationship. are tightly connected to transcription, thus providing early insight into the genome’s structure-function relationship