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Penghua Wang, PhD

Assistant Professor Adjunct

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Research Summary

My interests have been placed on reemerging infectious diseases and biodefense research. I am trying to understand how pathogens manipulate host factors for their own benefit and how host combats the invading pathogens.

Extensive Research Description

I am primarily interested in host-pathogen interaction, with a focus on RNA viruses in vivo and in vitro. Specifically, I wish to understand pathogenic mechanisms of viral infection at the cellular and animal levels, and study the molecular function of host genes that influence viral pathogenesis and the disease outcomes. On the host side, I am keen on the innate immune system, detection of viruses and initiation of antiviral immune response. On the virus side, I wish to understand the mechanisms of immune evasion.

The Flaviviridae family consists of a large number of ssRNA viruses that cause fatal human diseases. For example, West Nile virus (WNV) is the culprit of thousands of encephalitis/meningitis cases and deaths since 1999. Dengue virus (DENV) infects 50 to 100 million people worldwide a year with a mortality of 1–5% if untreated. Hepatitis C virus (HCV) affects ~3% of the world's population and causes 350,000 deaths yearly. I attempt to identify novel host factors that restrict or facilitate virus pathogenesis in vivo and in vitro. These factors may be regulators of host antiviral immune pathways or participants of viral life cycle including surface receptors mediating viral entry. Understanding the molecular mechanisms underlying the pathogenesis of these disease conditions and virus specific host immune response can advance the development of specific antiviral therapeutics and vaccines.

1. Roles of NLRs in antiviral immune responses and the pathogenesis of West Nile viral encephalitis

2. Roles of UBXNs in antiviral immune responses

Coauthors

Research Interests

Virus Diseases; Diseases

Public Health Interests

Immunology; Infectious Diseases; Mosquito-borne Diseases

Selected Publications

UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic HomeostasisGeng T, Yang D, Lin T, Cahoon J, Wang P. UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. MBio 2022, 13: e02687-22. PMID: 36377866, PMCID: PMC9765034, DOI: 10.1128/mbio.02687-22.
Quantitative Analysis of B-Cell Subpopulations in Bone Marrow by Flow CytometryGeng T, Wang P. Quantitative Analysis of B-Cell Subpopulations in Bone Marrow by Flow Cytometry. 2022, 2585: 71-77. PMID: 36331766, DOI: 10.1007/978-1-0716-2760-0_8.
Mosquito-borne pathogens hijack human body odors to promote transmissionWang P, Cheng G. Mosquito-borne pathogens hijack human body odors to promote transmission. Science China Life Sciences 2022, 66: 180-182. PMID: 36346549, DOI: 10.1007/s11427-022-2231-7.
Neighboring mutation‐mediated enhancement of dengue virus infectivity and spreadChen L, Zhang X, Guo X, Peng W, Zhu Y, Wang Z, Yu X, Shi H, Li Y, Zhang L, Wang L, Wang P, Cheng G. Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread. EMBO Reports 2022, 23: e55671. PMID: 36197120, PMCID: PMC9638853, DOI: 10.15252/embr.202255671.
The noncanonical inflammasome in health and diseaseCahoon J, Yang D, Wang P. The noncanonical inflammasome in health and disease. Infectious Medicine 2022, 1: 208-216. PMID: 38077630, PMCID: PMC10699704, DOI: 10.1016/j.imj.2022.09.001.
A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular EntryTong L, Wang L, Liao S, Xiao X, Qu J, Wu C, Zhu Y, Tai W, Huang Y, Wang P, Li L, Zhang R, Xiang Y, Cheng G. A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry. MBio 2022, 13: e01485-22. PMID: 35862773, PMCID: PMC9426596, DOI: 10.1128/mbio.01485-22.
A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractivenessZhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell 2022, 185: 2510-2522.e16. PMID: 35777355, DOI: 10.1016/j.cell.2022.05.016.
Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoesYu X, Tong L, Zhang L, Yang Y, Xiao X, Zhu Y, Wang P, Cheng G. Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes. PLOS Pathogens 2022, 18: e1010552. PMID: 35679229, PMCID: PMC9182268, DOI: 10.1371/journal.ppat.1010552.
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2Tong L, Xiao X, Li M, Fang S, Ma E, Yu X, Zhu Y, Wu C, Tian D, Yang F, Sun J, Qu J, Zheng N, Liao S, Tai W, Feng S, Zhang L, Li Y, Wang L, Han X, Sun S, Yang L, Zhong H, Zhao J, Liu W, Liu X, Wang P, Li L, Zhao G, Zhang R, Cheng G. A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2. Nature Metabolism 2022, 4: 547-558. PMID: 35534727, DOI: 10.1038/s42255-022-00567-z.
Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunctionYang D, Dai X, Xing Y, Tang X, Yang G, Harrison A, Cahoon J, Li H, Lv X, Yu X, Wang P, Wang H. Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction. Communications Biology 2022, 5: 96. PMID: 35079095, PMCID: PMC8789803, DOI: 10.1038/s42003-022-03007-6.
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoesZhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.
STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid NephropathyJiao B, An C, Du H, Tran M, Wang P, Zhou D, Wang Y. STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy. Cells 2021, 10: 3057. PMID: 34831280, PMCID: PMC8623460, DOI: 10.3390/cells10113057.
A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian hostYu X, Shan C, Zhu Y, Ma E, Wang J, Wang P, Shi P, Cheng G. A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2113015118. PMID: 34620704, PMCID: PMC8545446, DOI: 10.1073/pnas.2113015118.
Mitofusin‐2 regulates leukocyte adhesion and β2 integrin activationLiu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. Mitofusin‐2 regulates leukocyte adhesion and β2 integrin activation. Journal Of Leukocyte Biology 2021, 111: 771-791. PMID: 34494308, PMCID: PMC8901796, DOI: 10.1002/jlb.1a0720-471r.
Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal FibrosisJiao B, An C, Tran M, Du H, Wang P, Zhou D, Wang Y. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers In Immunology 2021, 12: 735014. PMID: 34512669, PMCID: PMC8426438, DOI: 10.3389/fimmu.2021.735014.
A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous systemYang D, Lin T, Li C, Harrison A, Geng T, Wang P. A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system. IScience 2021, 24: 102678. PMID: 34169243, PMCID: PMC8208900, DOI: 10.1016/j.isci.2021.102678.
UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling.Ketkar H, Harrison A, Graziano V, Geng T, Yang L, Vella A, Wang P. UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. The Journal Of Immunology 2021, 206: 2682-2691. PMID: 34021047, PMCID: PMC8164993, DOI: 10.4049/jimmunol.1901337.
Mitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiationFan Z, Liu W, Wang Y, Hsu A, Lin T, Sun H, Pachter J, Groisman A, Imperioli M, Yungher F, Hu L, Wang P, Deng Q. Mitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiation. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.00211.
Interaction of Viruses with the Insect IntestineMa E, Zhu Y, Liu Z, Wei T, Wang P, Cheng G. Interaction of Viruses with the Insect Intestine. Annual Review Of Virology 2021, 8: 1-17. PMID: 33872516, DOI: 10.1146/annurev-virology-091919-100543.
Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pHWang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J. Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Cell Reports 2021, 35: 108992. PMID: 33882310, PMCID: PMC8116483, DOI: 10.1016/j.celrep.2021.108992.
A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus.Geng T, Lin T, Yang D, Harrison AG, Vella AT, Fikrig E, Wang P. A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus. The Journal Of Infectious Diseases 2020, 223: 2186-2196. PMID: 33161431, PMCID: PMC8205639, DOI: 10.1093/infdis/jiaa694.
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic AlphavirusesLin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.
Mechanisms of SARS-CoV-2 Transmission and PathogenesisHarrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. Trends In Immunology 2020, 41: 1100-1115. PMID: 33132005, PMCID: PMC7556779, DOI: 10.1016/j.it.2020.10.004.
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in miceYang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology 2020, 3: 556. PMID: 33033362, PMCID: PMC7545163, DOI: 10.1038/s42003-020-01285-6.
Roles of Symbiotic Microorganisms in Arboviral Infection of Arthropod VectorsYin C, Sun P, Yu X, Wang P, Cheng G. Roles of Symbiotic Microorganisms in Arboviral Infection of Arthropod Vectors. Trends In Parasitology 2020, 36: 607-615. PMID: 32386795, DOI: 10.1016/j.pt.2020.04.009.
A mosquito salivary protein promotes flavivirus transmission by activation of autophagySun P, Nie K, Zhu Y, Liu Y, Wu P, Liu Z, Du S, Fan H, Chen CH, Zhang R, Wang P, Cheng G. A mosquito salivary protein promotes flavivirus transmission by activation of autophagy. Nature Communications 2020, 11: 260. PMID: 31937766, PMCID: PMC6959235, DOI: 10.1038/s41467-019-14115-z.
Progress towards Understanding the Mosquito-Borne Virus Life CycleYu X, Zhu Y, Xiao X, Wang P, Cheng G. Progress towards Understanding the Mosquito-Borne Virus Life Cycle. Trends In Parasitology 2019, 35: 1009-1017. PMID: 31669148, DOI: 10.1016/j.pt.2019.09.006.
Host serum iron modulates dengue virus acquisition by mosquitoesZhu Y, Tong L, Nie K, Wiwatanaratanabutr I, Sun P, Li Q, Yu X, Wu P, Wu T, Yu C, Liu Q, Bian Z, Wang P, Cheng G. Host serum iron modulates dengue virus acquisition by mosquitoes. Nature Microbiology 2019, 4: 2405-2415. PMID: 31527795, DOI: 10.1038/s41564-019-0555-x.
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancersCao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe 2019, 26: 369-384.e8. PMID: 31513772, DOI: 10.1016/j.chom.2019.08.010.
Chikungunya Virus and (Re-) Emerging AlphavirusesWang P, Zhang R. Chikungunya Virus and (Re-) Emerging Alphaviruses. Viruses 2019, 11: 779. PMID: 31450552, PMCID: PMC6784149, DOI: 10.3390/v11090779.
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STINGWang P, Li S, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. Journal Of Biological Chemistry 2019, 294: 16494-16508. PMID: 31416833, PMCID: PMC6851339, DOI: 10.1074/jbc.ra119.009172.
Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA ExpressionZhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T, Qian F. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio 2019, 10: e00937-19. PMID: 31363026, PMCID: PMC6667616, DOI: 10.1128/mbio.00937-19.
Identification of genetic variations in Necator americanus through resequencing by whole genome amplificationLiu Y, Liu H, Xie Y, Zhang B, Zou X, Ou M, Ye X, Han Y, Wu J, Chen X, Dong S, Zhu K, Guo C, Wang P, Zhai H, Jing C, Yang G. Identification of genetic variations in Necator americanus through resequencing by whole genome amplification. Journal Of International Medical Research 2019, 47: 4353-4364. PMID: 31331217, PMCID: PMC6753555, DOI: 10.1177/0300060519862069.
Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine systemKetkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagnostic Microbiology And Infectious Disease 2019, 95: 38-40. PMID: 31097261, PMCID: PMC6697611, DOI: 10.1016/j.diagmicrobio.2019.03.012.
Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environmentsDu S, Liu Y, Liu J, Zhao J, Champagne C, Tong L, Zhang R, Zhang F, Qin CF, Ma P, Chen CH, Liang G, Liu Q, Shi PY, Cazelles B, Wang P, Tian H, Cheng G. Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments. Nature Communications 2019, 10: 1324. PMID: 30902991, PMCID: PMC6430813, DOI: 10.1038/s41467-019-09256-0.
Arbovirus lifecycle in mosquito: acquisition, propagation and transmissionWu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Reviews In Molecular Medicine 2019, 21: e1. PMID: 30862324, DOI: 10.1017/erm.2018.6.
Genetic Determinants of the Re-Emergence of Arboviral DiseasesKetkar H, Herman D, Wang P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses 2019, 11: 150. PMID: 30759739, PMCID: PMC6410223, DOI: 10.3390/v11020150.
A Gut Commensal Bacterium Promotes Mosquito Permissiveness to ArbovirusesWu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host & Microbe 2018, 25: 101-112.e5. PMID: 30595552, DOI: 10.1016/j.chom.2018.11.004.
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3Wang K, Zou C, Wang X, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLOS Pathogens 2018, 14: e1007287. PMID: 30142214, PMCID: PMC6126873, DOI: 10.1371/journal.ppat.1007287.
Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS SignalingMa J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, Wang P. Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling. Frontiers In Microbiology 2018, 9: 1350. PMID: 29988497, PMCID: PMC6026624, DOI: 10.3389/fmicb.2018.01350.
UBXN3B positively regulates STING-mediated antiviral immune responsesYang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications 2018, 9: 2329. PMID: 29899553, PMCID: PMC5998066, DOI: 10.1038/s41467-018-04759-8.
Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage.Zou J, Chen Z, Liang C, Fu Y, Wei X, Lu J, Pan M, Guo Y, Liao X, Xie H, Wu D, Li M, Liang L, Wang P, Wang Q. Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage. Aging And Disease 2018, 9: 51-65. PMID: 29392081, PMCID: PMC5772858, DOI: 10.14336/AD.2017.0416.
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy 2018, 14: 336-346. PMID: 29166823, PMCID: PMC5902195, DOI: 10.1080/15548627.2017.1405187.
The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.Gao X, Xie H, Zhu S, Yu B, Xian Y, Ouyang Q, Ji Y, Yang X, Wen C, Wang P, Tong Y, Wang Q. The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration. Frontiers In Aging Neuroscience 2018, 10: 196. PMID: 30050428, PMCID: PMC6050362, DOI: 10.3389/fnagi.2018.00196.
Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic systemZhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications 2017, 8: 1262. PMID: 29093445, PMCID: PMC5665997, DOI: 10.1038/s41467-017-01244-6.
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase InterferenceSze A, Olagnier D, Hadj SB, Han X, Tian XH, Xu HT, Yang L, Shi Q, Wang P, Wainberg MA, Wu JH, Lin R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 2017, 9: 287. PMID: 28972551, PMCID: PMC5691638, DOI: 10.3390/v9100287.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cellsZhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.
An essential role of PI3K in the control of West Nile virus infectionWang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports 2017, 7: 3724. PMID: 28623344, PMCID: PMC5473900, DOI: 10.1038/s41598-017-03912-5.
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoesLiu Y, Liu J, Du S, Shan C, Nie K, Zhang R, Li XF, Zhang R, Wang T, Qin CF, Wang P, Shi PY, Cheng G. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature 2017, 545: 482-486. PMID: 28514450, PMCID: PMC5885636, DOI: 10.1038/nature22365.
A Mesh–Duox pathway regulates homeostasis in the insect gutXiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh–Duox pathway regulates homeostasis in the insect gut. Nature Microbiology 2017, 2: 17020. PMID: 28248301, PMCID: PMC5332881, DOI: 10.1038/nmicrobiol.2017.20.
Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource SettingCheng C, Wu J, Fikrig E, Wang P, Chen J, Eda S, Terry P. Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource Setting. ChemElectroChem 2017, 4: 485-489. DOI: 10.1002/celc.201600831.
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoesLiu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology 2016, 1: 16087. PMID: 27562253, PMCID: PMC5003325, DOI: 10.1038/nmicrobiol.2016.87.
Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome ReplicationWang K, Wang J, Sun T, Bian G, Pan W, Feng T, Wang P, Li Y, Dai J. Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication. International Journal Of Biological Sciences 2016, 12: 872-883. PMID: 27313500, PMCID: PMC4910605, DOI: 10.7150/ijbs.15641.
Exploration of West Nile Virus Infection in Mouse ModelsWang P. Exploration of West Nile Virus Infection in Mouse Models. 2016, 1435: 71-81. PMID: 27188551, DOI: 10.1007/978-1-4939-3670-0_7.
Mosquito C-type lectins maintain gut microbiome homeostasis.Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.
Mosquito C-type lectins maintain gut microbiome homeostasisPang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27170846, PMCID: PMC4861079, DOI: 10.1038/nmicrobiol.2016.23.
Mosquito Defense Strategies against Viral InfectionCheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends In Parasitology 2015, 32: 177-186. PMID: 26626596, PMCID: PMC4767563, DOI: 10.1016/j.pt.2015.09.009.
A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of MosquitoesXiao X, Zhang R, Pang X, Liang G, Wang P, Cheng G. A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes. PLOS Pathogens 2015, 11: e1004848. PMID: 25915054, PMCID: PMC4411065, DOI: 10.1371/journal.ppat.1004848.
Mosquito Saliva Serine Protease Enhances Dissemination of Dengue Virus into the Mammalian HostConway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito Saliva Serine Protease Enhances Dissemination of Dengue Virus into the Mammalian Host. Journal Of Virology 2013, 88: 164-175. PMID: 24131723, PMCID: PMC3911723, DOI: 10.1128/jvi.02235-13.
UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVSWang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS. Cell Reports 2013, 3: 1057-1070. PMID: 23545497, PMCID: PMC3707122, DOI: 10.1016/j.celrep.2013.02.027.
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroDai J, Pan W, Wang P. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virology Journal 2011, 8: 468. PMID: 21992229, PMCID: PMC3215395, DOI: 10.1186/1743-422x-8-468.
Innate immune control of West Nile virus infectionArjona A, Wang P, Montgomery RR, Fikrig E. Innate immune control of West Nile virus infection. Cellular Microbiology 2011, 13: 1648-1658. PMID: 21790942, PMCID: PMC3196381, DOI: 10.1111/j.1462-5822.2011.01649.x.
Dengue Virus Capsid Protein Binds Core Histones and Inhibits Nucleosome Formation in Human Liver CellsColpitts TM, Barthel S, Wang P, Fikrig E. Dengue Virus Capsid Protein Binds Core Histones and Inhibits Nucleosome Formation in Human Liver Cells. PLOS ONE 2011, 6: e24365. PMID: 21909430, PMCID: PMC3164731, DOI: 10.1371/journal.pone.0024365.
Alterations in the Aedes aegypti Transcriptome during Infection with West Nile, Dengue and Yellow Fever VirusesColpitts TM, Cox J, Vanlandingham DL, Feitosa FM, Cheng G, Kurscheid S, Wang P, Krishnan MN, Higgs S, Fikrig E. Alterations in the Aedes aegypti Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses. PLOS Pathogens 2011, 7: e1002189. PMID: 21909258, PMCID: PMC3164632, DOI: 10.1371/journal.ppat.1002189.
An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral InfectionCheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral Infection. PLOS ONE 2011, 6: e22786. PMID: 21818390, PMCID: PMC3144946, DOI: 10.1371/journal.pone.0022786.
prM-antibody renders immature West Nile virus infectious in vivoColpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. Journal Of General Virology 2011, 92: 2281-2285. PMID: 21697345, PMCID: PMC3347797, DOI: 10.1099/vir.0.031427-0.
Tick Histamine Release Factor Is Critical for Ixodes scapularis Engorgement and Transmission of the Lyme Disease AgentDai J, Narasimhan S, Zhang L, Liu L, Wang P, Fikrig E. Tick Histamine Release Factor Is Critical for Ixodes scapularis Engorgement and Transmission of the Lyme Disease Agent. PLOS Pathogens 2010, 6: e1001205. PMID: 21124826, PMCID: PMC2991271, DOI: 10.1371/journal.ppat.1001205.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-IWang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology 2010, 11: 912-919. PMID: 20818395, PMCID: PMC3712356, DOI: 10.1038/ni.1933.
A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of MosquitoesCheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes. Cell 2010, 142: 714-725. PMID: 20797779, PMCID: PMC2954371, DOI: 10.1016/j.cell.2010.07.038.
Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease AgentDai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent. Cell Host & Microbe 2009, 6: 482-492. PMID: 19917502, PMCID: PMC2843562, DOI: 10.1016/j.chom.2009.10.006.
The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferiHovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, van der Poll T. The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi. PLOS Pathogens 2009, 5: e1000447. PMID: 19461880, PMCID: PMC2678258, DOI: 10.1371/journal.ppat.1000447.
Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moietyYang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes And Infection 2008, 10: 1300-1308. PMID: 18725314, PMCID: PMC2648844, DOI: 10.1016/j.micinf.2008.07.029.
Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain▿Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain▿. Journal Of Virology 2008, 82: 8978-8985. PMID: 18632868, PMCID: PMC2546894, DOI: 10.1128/jvi.00314-08.
ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System▿Dai J, Wang P, Bai F, Town T, Fikrig E. ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System▿. Journal Of Virology 2008, 82: 4164-4168. PMID: 18256150, PMCID: PMC2292986, DOI: 10.1128/jvi.02621-07.
A Differential Role for BB0365 in the Persistence of Borrelia burgdorferi in Mice and TicksPal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A Differential Role for BB0365 in the Persistence of Borrelia burgdorferi in Mice and Ticks. The Journal Of Infectious Diseases 2008, 197: 148-155. PMID: 18171298, DOI: 10.1086/523764.
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritisPal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. Journal Of Experimental Medicine 2007, 205: 133-141. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.
AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.Wang P, Zhang Y, Li H, Chieu HK, Munn AL, Yang H. AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. The EMBO Journal 2005, 24: 2989-99. PMID: 16096648, PMCID: PMC1201346, DOI: 10.1038/sj.emboj.7600764.
Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae.Wang P, Duan W, Munn AL, Yang H. Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae. The FEBS Journal 2005, 272: 4703-15. PMID: 16156791, DOI: 10.1111/j.1742-4658.2005.04886.x.
IL-22 contributes to West Nile virus encephalitis via neutrophils.2. Penghua Wang (correspondence author), Fengwei Bai , Lauren A. Zenewicz, Jianfeng Dai, Long Yang, David Gate, Eric Cheng, Richard A. Flavell, Terrence Town, Erol Fikrig. IL-22 contributes to West Nile virus encephalitis via neutrophils. PLoS ONE 2012,

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Penghua Wang, PhD

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