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Jonathan DeLong, PhD

Postdoctoral Associate

Research & Publications
Biography

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Selected Publications

Abstract TP216: Suppression Of Macrophage Activation By MyelinDeLong J, Sun L, Velazquez S, Landreneau M, Sansing L. Abstract TP216: Suppression Of Macrophage Activation By Myelin. Stroke 2023, 54: atp216-atp216. DOI: 10.1161/str.54.suppl_1.tp216.
Role of Inflammatory Processes in Hemorrhagic StrokeOhashi S, DeLong J, Kozberg M, Mazur-Hart D, van Veluw S, Alkayed N, Sansing L. Role of Inflammatory Processes in Hemorrhagic Stroke. Stroke 2023, 54: 605-619. PMID: 36601948, DOI: 10.1161/strokeaha.122.037155.
Inflammatory Responses After Ischemic StrokeDeLong JH, Ohashi SN, O’Connor K, Sansing LH. Inflammatory Responses After Ischemic Stroke. Seminars In Immunopathology 2022, 44: 625-648. PMID: 35767089, DOI: 10.1007/s00281-022-00943-7.
Cholesterol, LXR activation, and myelin uptake in the macrophage response to diverse signalsDeLong J, Velazquez S, Sun L, Landreneau M, Sansing L. Cholesterol, LXR activation, and myelin uptake in the macrophage response to diverse signals. The Journal Of Immunology 2022, 208: 111.23-111.23. DOI: 10.4049/jimmunol.208.supp.111.23.
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infectionPerry J, Shallberg L, Clark J, Gullicksrud J, DeLong J, Douglas B, Hart A, Lanzar Z, O’Dea K, Konradt C, Park J, Kuchroo J, Grubaugh D, Zaretsky A, Brodsky I, Malefyt R, Christian D, Sharpe A, Hunter C. PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 2022, 23: 743-756. PMID: 35437326, PMCID: PMC9106844, DOI: 10.1038/s41590-022-01170-w.
Abstract TP239: Cholesterol And LXR Signaling In The Macrophage Response To Intracerebral Hemorrhage-relevant StimulationDelong J, Velazquez S, Sun L, Landreneau M, Sansing L. Abstract TP239: Cholesterol And LXR Signaling In The Macrophage Response To Intracerebral Hemorrhage-relevant Stimulation. Stroke 2022, 53: atp239-atp239. DOI: 10.1161/str.53.suppl_1.tp239.
Abstract 99: Single Cell RNA-Sequencing Reveals Array Of Immune Activation States In Intracerebral HemorrhageJohnson C, Askenase M, Beatty H, DeLong J, Zhang L, Sheth K, Cord B, Hebert R, Matouk C, Sansing L. Abstract 99: Single Cell RNA-Sequencing Reveals Array Of Immune Activation States In Intracerebral Hemorrhage. Stroke 2022, 53: a99-a99. DOI: 10.1161/str.53.suppl_1.99.
Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic BrainChang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, DeLong JH, Hammond MD, Massey J, Landreneau M, Love JC, Sansing LH. Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain. Stroke 2021, 52: 1798-1808. PMID: 33840225, PMCID: PMC8085165, DOI: 10.1161/strokeaha.120.032196.
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieuGoods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH, Investigators T. Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu. JCI Insight 2021, 6: e145857. PMID: 33749664, PMCID: PMC8026179, DOI: 10.1172/jci.insight.145857.
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA. Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. The Journal Of Immunology 2020, 205: 377-386. PMID: 32522836, PMCID: PMC7368461, DOI: 10.4049/jimmunol.1901463.
Abstract 178: Cholesterol Limits Macrophage Activation in Response to Intracerebral Hemorrhage-Relevant SignalsDeLong J, Velazquez S, Landreneau M, Sansing L. Abstract 178: Cholesterol Limits Macrophage Activation in Response to Intracerebral Hemorrhage-Relevant Signals. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.178.
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis.Park J, DeLong JH, Knox JJ, Konradt C, Wojno EDT, Hunter CA. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Infection And Immunity 2019, 87 PMID: 31548322, PMCID: PMC6867838, DOI: 10.1128/iai.00455-19.
IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory ReceptorsDeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. ImmunoHorizons 2019, 3: 13-25. PMID: 31356173, PMCID: PMC6994206, DOI: 10.4049/immunohorizons.1800083.
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. The Journal Of Immunology 2018, 200: 1761-1770. PMID: 29358280, PMCID: PMC5821564, DOI: 10.4049/jimmunol.1701154.
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disordersWambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Science Translational Medicine 2017, 9 PMID: 28768806, PMCID: PMC5987220, DOI: 10.1126/scitranslmed.aam9171.
IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTIONMuallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Christian DA, Pritchard G, Fang Q, Buza EL, Jain D, Elloso MM, López CB, Hunter CA. IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION. PLOS Pathogens 2017, 13: e1006173. PMID: 28129374, PMCID: PMC5305264, DOI: 10.1371/journal.ppat.1006173.
Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cellsYang YQ, Dong WJ, Yin XF, Xu YN, Yang Y, Wang JJ, Yuan SJ, Xiao J, DeLong JH, Chu L, Xu HN, Zhou XM, Wang RW, Fang L, Liu XY, Zhang KJ. Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells. Protein & Cell 2016, 7: 538-543. PMID: 27295261, PMCID: PMC4930771, DOI: 10.1007/s13238-016-0281-6.
Ly6C expression on T cells is modulated by IL-27, interferon-gamma and TCR stimulationDeLong J, Hall A, Muallem G, Hunter C. Ly6C expression on T cells is modulated by IL-27, interferon-gamma and TCR stimulation. The Journal Of Immunology 2016, 196: 196.9-196.9. DOI: 10.4049/jimmunol.196.supp.196.9.
Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous systemKonradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology 2016, 1: 16001. PMID: 27572166, PMCID: PMC4966557, DOI: 10.1038/nmicrobiol.2016.1.
Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor CellsYang Y, DeLong J, Zhang K. Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells. Single Cell Biology 2016, 5: 1-2. DOI: 10.4172/2168-9431.1000146.
Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cellsRenand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells. Journal Of Allergy And Clinical Immunology 2014, 134: 1456-1459.e7. PMID: 25224098, PMCID: PMC4349443, DOI: 10.1016/j.jaci.2014.07.048.
Grass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapyArchila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW. Grass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapy. Clinical & Experimental Allergy 2014, 44: 986-998. PMID: 24708411, PMCID: PMC4069242, DOI: 10.1111/cea.12324.
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in miceChen L, Yang G, Monslow J, Todd L, Cormode DP, Tang J, Grant GR, DeLong JH, Tang SY, Lawson JA, Pure E, FitzGerald GA. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6828-6833. PMID: 24753592, PMCID: PMC4020105, DOI: 10.1073/pnas.1401797111.
Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent mannerWambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner. Journal Of Allergy And Clinical Immunology 2013, 133: 872-879.e7. PMID: 24373351, PMCID: PMC3961577, DOI: 10.1016/j.jaci.2013.10.054.
T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature Immunology 2013, 14: 1277-1284. PMID: 24185616, PMCID: PMC4038953, DOI: 10.1038/ni.2760.
Cross Reactivity Patterns of DRB1*0401 Restricted T- Cells Specific for Epitopes From the Pooideae Grass SpeciesArchila L, Delong J, Wambre E, James E, Robinson D, Kwok W. Cross Reactivity Patterns of DRB1*0401 Restricted T- Cells Specific for Epitopes From the Pooideae Grass Species. Journal Of Allergy And Clinical Immunology 2013, 131: ab193. DOI: 10.1016/j.jaci.2012.12.1358.
Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory RepertoireKwok WW, Tan V, Gillette L, Littell CT, Soltis MA, LaFond RB, Yang J, James EA, DeLong JH. Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire. The Journal Of Immunology 2012, 188: 2537-2544. PMID: 22327072, PMCID: PMC3997369, DOI: 10.4049/jimmunol.1102190.
124 Heterogeneity of Allergen Epitope-specific CD4+ T Cells ResponsesWambre E, Delong J, James E, Torres-Chinn N, Robinson D, Kwok W. 124 Heterogeneity of Allergen Epitope-specific CD4+ T Cells Responses. World Allergy Organization Journal 2012, 5: s58-s59. PMCID: PMC3513055, DOI: 10.1097/01.wox.0000411869.96996.a9.
Ex Vivo Characterization of the Epitope-Specific T Cell Response to AlternariaDeLong J, Wambre E, LaFond R, Torres-Chinn N, James E, Robinson D, Kwok W. Ex Vivo Characterization of the Epitope-Specific T Cell Response to Alternaria. Journal Of Allergy And Clinical Immunology 2012, 129: ab197. DOI: 10.1016/j.jaci.2011.12.299.
TH2A Cells As a Unique TH2 Cell Subset in Allergic Individuals: Steps Toward a T Cell Biomarker For AllergyWambre E, DeLong J, James E, Robinson D, Kwok W. TH2A Cells As a Unique TH2 Cell Subset in Allergic Individuals: Steps Toward a T Cell Biomarker For Allergy. Journal Of Allergy And Clinical Immunology 2012, 129: ab129. DOI: 10.1016/j.jaci.2011.12.429.
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapyWambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. Journal Of Allergy And Clinical Immunology 2011, 129: 544-551.e7. PMID: 21975176, PMCID: PMC3268867, DOI: 10.1016/j.jaci.2011.08.034.
Ara h 1–reactive T cells in individuals with peanut allergyDeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1–reactive T cells in individuals with peanut allergy. Journal Of Allergy And Clinical Immunology 2011, 127: 1211-1218.e3. PMID: 21459424, PMCID: PMC3130623, DOI: 10.1016/j.jaci.2011.02.028.
Distinct Maturational Stages Lead to Different Fates of Pathologic and Protective Allergen-Specific CD4+ memory T Cells during Specific ImmunotherapyWambre E, DeLong J, Robinson D, Kwok W. Distinct Maturational Stages Lead to Different Fates of Pathologic and Protective Allergen-Specific CD4+ memory T Cells during Specific Immunotherapy. Journal Of Allergy And Clinical Immunology 2011, 127: ab257. DOI: 10.1016/j.jaci.2010.12.1025.
Different Epitopes From The Same Timothy Grass Allergen Can Elicit CD4+ T Cells With Distinct Immune FunctionsKwok W, Delong J, Till S, Robinson D, Wambre E. Different Epitopes From The Same Timothy Grass Allergen Can Elicit CD4+ T Cells With Distinct Immune Functions. Journal Of Allergy And Clinical Immunology 2011, 127: ab258. DOI: 10.1016/j.jaci.2010.12.1026.
Ex Vivo Characterization of the CD4+ T Cell Response to Ara h 1DeLong J, Hetherington K, Wambre E, Robinson D, Kwok W. Ex Vivo Characterization of the CD4+ T Cell Response to Ara h 1. Journal Of Allergy And Clinical Immunology 2011, 127: ab257. DOI: 10.1016/j.jaci.2010.12.1024.
Direct ex vivo analysis of allergen-specific CD4+ T cellsKwok WW, Roti M, DeLong JH, Tan V, Wambre E, James EA, Robinson D. Direct ex vivo analysis of allergen-specific CD4+ T cells. Journal Of Allergy And Clinical Immunology 2010, 125: 1407-1409.e1. PMID: 20513526, PMCID: PMC3909500, DOI: 10.1016/j.jaci.2010.03.037.
CD4+ T Cells Specific for a Single Alder (Aln g 1) Epitope Exhibit Different Effector Functions Dependent on their HLA-DR RestrictionsKwok W, DeLong J, James E, Robinson D, Wambre E. CD4+ T Cells Specific for a Single Alder (Aln g 1) Epitope Exhibit Different Effector Functions Dependent on their HLA-DR Restrictions. Journal Of Allergy And Clinical Immunology 2010, 125: ab40. DOI: 10.1016/j.jaci.2009.12.191.
Heterogeneity of Phl p 1 and Phl p 5 Reactive T Cells in Subjects with Timothy Grass AllergyWambre E, Delong J, Till S, Robinson D, Kwok W. Heterogeneity of Phl p 1 and Phl p 5 Reactive T Cells in Subjects with Timothy Grass Allergy. Journal Of Allergy And Clinical Immunology 2010, 125: ab41. DOI: 10.1016/j.jaci.2009.12.195.
CD4+ T Cell Response to Fel d 4 Lipocalin: Epitope Identification and Ex Vivo CharacterizationDeLong J, Wambre E, Robinson D, Kwok W. CD4+ T Cell Response to Fel d 4 Lipocalin: Epitope Identification and Ex Vivo Characterization. Journal Of Allergy And Clinical Immunology 2010, 125: ab40. DOI: 10.1016/j.jaci.2009.12.189.
Investigation of Group 5 Grass Allergen T Cell Cross-reactivity by Multi-tetramer AnalysisDelong J, Till S, Roti M, Tan V, James E, Robinson D, Kwok W. Investigation of Group 5 Grass Allergen T Cell Cross-reactivity by Multi-tetramer Analysis. Journal Of Allergy And Clinical Immunology 2009, 123: s125. DOI: 10.1016/j.jaci.2008.12.463.
A New Approach for Identifying the Specificity, Frequency and Phenotype of CD4 + Allergen-reactive T CellsKwok W, Roti M, Delong J, Tan V, James E, Robinson D. A New Approach for Identifying the Specificity, Frequency and Phenotype of CD4 + Allergen-reactive T Cells. Journal Of Allergy And Clinical Immunology 2009, 123: s144. DOI: 10.1016/j.jaci.2008.12.536.

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