Cancer metastasis remains an unresolved clinical and biological problem. This is particularly relevant in the case of thoracic malignancies, which can spread aggressively to distant organs with limited opportunity for effective therapeutic intervention. Metastatic cancer cells are believed to acquire complex biological properties by deregulating pleiotoropic molecular programs and interacting with their microenvironment. My laboratory is interested in uncovering the epigenetic, cellular, and physiological determinants of metastasis by different lung cancer subtypes. Lung cancers as well as other tumor types such as breast cancer and melanoma most notably metastasize to the central nervous system. We are therefore also studying how the unique brain microenvironment alters the therapeutic response of disseminated tumor cells across different cancers. In our endeavors, we utilize a variety of approaches such as animal modeling, human biospecimen research, functional genomics, cell biology, and bioinformatics.
Specialized Terms: Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment; Brain metastasis
Inflammation; Neoplasm Metastasis; Pathology; Genomics; Epigenomics; Tumor Microenvironment; Neoplasm Micrometastasis
Cancer; Genetics, Genomics, Epigenetics